Results 61 to 70 of about 5,060,080 (299)

Designing Blended Spaces [PDF]

Electronic Workshops in Computing, 2012
We present an approach to the design of mixed reality spaces that aims to create a more harmonized and unified user experience. We refer to these as blended spaces. Blended spaces draw upon a description of physical and digital spaces in terms of the ontology, topology, volatility and agency.
David Benyon, Oli Mival, Serkan Ayan
openaire   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Optimization of In Vitro Transcription by Design of Experiment to Achieve High Self-Amplifying RNA Integrity

Vaccines
Background: Self-amplifying mRNA (saRNA) holds promising application prospects. However, due to the inclusion of a replicase sequence, its extended length leads to premature termination during in vitro transcription (IVT), resulting in poor product ...
Chaoying Hu, Haixin Wang, Guanxing Liu, Kelei Li, Xuanxuan Zhang, Lifang Song, Fan Gao, Xing Wu, Qian Wang, Mingchen Liu, Jianyang Liu, Zhihao Fu, Xiao Ma, Miao Xu, Qunying Mao, Zhenglun Liang, Qian He   +16 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Realization of SRRC filter and multi-rate conversion based on FPGA

Dianzi Jishu Yingyong, 2018
In order to eliminate the inter symbol interference(ISI) in the communication system and improve the band utilization, the square root-raised cosine filter is often used to realize the base-band shaping filter of the baseband signal.
Yang Yang, Yan Zheng, Liu Minwei, Dong Jicheng   +3 more
doaj   +1 more source

Risk assessment and integrated process modeling–an improved QbD approach for the development of the bioprocess control strategy

AIMS Bioengineering, 2020
A Process characterization is a regulatory imperative for process validation within the biopharmaceutical industry. Several individual steps must be conducted to achieve the final control strategy. For that purpose, tools from the Quality by Design (QbD)
Daniel Borchert, Diego A. Suarez-Zuluaga, Yvonne E. Thomassen, Christoph Herwig   +3 more
doaj   +1 more source

Space test program of high-voltage solar array-space plasma interactions [PDF]

, 1985
Future spacecraft, notably the proposed Space Station, will require power systems much larger than have previously been flown. It is recognized that at higher voltages, and at the relatively high plasma density present at low Earth orbital altitudes ...
Carruth, M. R., Jr., Purvis, C. K.
core   +1 more source

Exploring the Design Space of Immersive Urban Analytics

, 2017
Recent years have witnessed the rapid development and wide adoption of immersive head-mounted devices, such as HTC VIVE, Oculus Rift, and Microsoft HoloLens.
Chen, Wei, Chen, Zhutian, Gao, Xiang, Pan, Zhigeng, Qu, Huamin, Sun, Tianchen, Wang, Yifang, Wu, Yingcai   +7 more
core   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source