Results 81 to 90 of about 5,060,080 (299)
Design challenges for space bioreactors [PDF]
The design of bioreactors for operation under conditions of microgravity presents problems and challenges. Absence of a significant body force such as gravity can have profound consequences for interfacial phenomena. Marangoni convection can no longer be
Petersen, G. R., Seshan, P. K.
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Space vehicle displays design criteria [PDF]
The guidance, navigation, and control displays associated with manned spaceflight are summarized. Major emphasis were placed on methodologies useful for determining necessary information and its uses, systems analysis techniques, and analytic methods for
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Space bioreactor: Design/process flow [PDF]
The design of the space bioreactor stems from three considerations. First, and foremost, it must sustain cells in microgravity. Closely related is the ability to take advantage of the weightlessness and microgravity.
Cross, John H.
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Uncertainty modelling in reliable preliminary space mission design [PDF]
, 2007 In the early phase of the design of a space mission, it is generally desirable to investigate as many feasible alternative solutions as possible. At this particular stage, an insufficient consideration for uncertainty would lead to a wrong decision on ...
Ceriotti, M. +2 more
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Space Settlements: A Design Study [PDF]
Nineteen professors of engineering, physical science, social science, and architecture, three volunteers, six students, a technical director, and two co-directors worked for ten weeks to construct a convincing picture of how people might permanently ...
Holbrow, Charles, Johnson, Richard D.
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Nickel-hydrogen batteries from Intelsat 5 to space station [PDF]
, 1986 The heritage of the Ni-H2 technology that makes the space station application feasible is discussed. It also describes a design for a potential space station Ni-H2 battery system.
Applewhite, A. Z., Vanommering, G.
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Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source