Results 131 to 140 of about 2,150,399 (264)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PERANCANGAN UI/UX SISTEM MONITORING DAN EVALUASI MUSRENBANG MENGGUNAKAN METODE DESIGN THINKING (Studi Kasus Bappeda Kabupaten Malang) [PDF]

This study focuses on the design of a UI/UX monitoring and evaluation system for the Musrenbang using the Design Thinking method, specifically for the Bappeda of Malang Regency.
Khuluq, Mohamad Farid Wafi Husnul
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Systems thinking for design thinking. [PDF]

, 2015
This article seeks to contribute to a discussion which could propitiate, in my opinion, the emergence of interesting connections between the Systemic Design field, German media theory, and the work of Bruno Latour on Science and Technology Studies (STS).
Darzentas, Jenny, Darzentas, John
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring Career and Life Design: Innovation, Resilience, and Personal Growth

CERN IdeaSquare Journal of Experimental Innovation
In the scientific spirit of CERN, this Special Issue focuses on humanity's biggest experiment: Life Design. It is about transformations and innovations related to the most profound questions of what it means to design your life in your personal and ...
Bettina Maisch, Steven Gedeon, Barbara Wolf, Karina Cagarman, Sebastian Kernbach   +4 more
doaj   +1 more source

Does design education always produce designers?

, 2011
By questioning what we mean by the term ‘designer’ this paper describes the ideas behind a new Open University course in Design Thinking. The paper shows how the creative skills of students can be consciously developed, and deliberately applied outside ...
Lloyd, Peter
core  

Mediating Effects of Positive Thinking and Social Support on Suicide Resilience [PDF]

, 2018
Suicide has been the second leading cause of death for 18- to 24-year-olds in the United States since 2011. The stress experienced by undergraduate college students has the potential to increase one’s risk for suicide.
Bekhet, Abir K., Garnier-Villarreal, Mauricio, Matel-Anderson, Denise M.   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source