Results 131 to 140 of about 16,272 (302)

Knowledge, attitudes, and practices of Chinese college students towards novel psychoactive substances

BMC Public Health
Background This study aimed to investigate the knowledge, attitudes, and practices (KAP) among Chinese college students regarding novel psychoactive substances (NPS), where practices specifically refer to behaviors related to NPS access and usage ...
Liqin Lu, Xinhao Zhou, Jue Deng, Binling Zhu, Liang Meng, Xianghui Lai, Xiaoli Zhu   +6 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors for Parkinson disease

npj Parkinson's Disease
In this review, we summarize preclinical and clinical trials investigating innovative neuromodulatory approaches for Parkinson disease (PD) motor symptom management.
A. D. Currie, J. K. Wong, M. S. Okun
doaj   +1 more source

Determinação de designer drugs em saliva por paper spray mass spectrometry

Química Nova
Determination of two drugs of abuse in saliva has been performed by Paper Spray Ionization Mass Spectrometry (PSI-MS) using a Molecularly Imprinted Polymer (MIP) coated paper as substrate.
Lanaia Ítala L. Maciel, Thays C. Carvalho, Igor Pereira, Boniek G. Vaz   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The synthetic cannabinoids menace: a review of health risks and toxicity

European Journal of Medical Research
Synthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe enough to damage the normal ...
Ayman Alzu’bi, Fatimah Almahasneh, Ramada Khasawneh, Ejlal Abu-El-Rub, Worood Bani Baker, Raed M. Al-Zoubi   +5 more
doaj   +1 more source

Opioid-like designer drugs: A practical review of detection, confirmation and interpretation

Journal of Pharmaceutical and Biomedical Analysis Open
Opioid-like designer drugs are a rapidly evolving subset of new psychoactive substances (NPS), potent synthetic opioids that increasingly challenge established toxicological and forensic workflows.
Michele Protti, Chiara Pia Iattoni, Hugo M. Santos, Carlos Lodeiro, José L. Capelo, Roberta Di Lecce, Roberto Mandrioli, Laura Mercolini   +7 more
doaj   +1 more source

The government just outlawed four popular 'designer' drugs.

, 2017
The freshly banned substances have been banned under the Misuse of Drugs Act.
Burke, Ceimin
core  

Cross-reactivities of 41 new amphetamine designer drugs to EMIT® immunoassays

, 2013
Amphetamine designer drugs are central nervous system stimulants, and are widely diffused in illegal markets. Monitoring of drugs of abuse in biological fluids is successfully used for clinical and forensic applications.
BOATTO, Gianpiero, PIRISI, Maria Antonietta, Burrai L, TRIGNANO, Claudia, Nieddu M   +4 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source