Results 131 to 140 of about 16,330 (302)
The New Wave of Designer Drugs: A Review for Criminal Justice and Forensic Professionals [PDF]
In recent decades, synthetic or designer drugs have continuously emerged like weeds. The manufacturers and distributors of synthetic substances are encouraged, at least in part, by the fuzzy legal status and low manufacturing cost of these drugs ...
Krasowski, Matthew D., Brown, Jerrod
core +1 more source
Regulatory options for the market of designer drugs [PDF]
, 2011 This paper describes an analyses the market of "legal" drugs, so called designer drugs, which emerged in Czech republic by the end of 2010, in other European countries about a year earlier.
Turek, Tomáš
core +2 more sources
Opioid-like designer drugs: A practical review of detection, confirmation and interpretation
Journal of Pharmaceutical and Biomedical Analysis OpenOpioid-like designer drugs are a rapidly evolving subset of new psychoactive substances (NPS), potent synthetic opioids that increasingly challenge established toxicological and forensic workflows.
Michele Protti +7 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The attitudes of young people to the non-use or use of drugs and to drugs education and prevention strategies [PDF]
, 1995 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study explores the attitudes of young people in the later years of their secondary education to the non-use or use of drugs and to the drugs education ...
Twigg, Barry
core
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Properties and detection of ‘designer drugs’ [PDF]
, 2013 W artykule opisano substancje o działaniu psychoaktywnym działające na ośrodkowy układ nerwowy. Są to związki lub też mieszaniny związków syntetycznych (m.in.
Jakubowska, I., Choma, J.
core
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source