Results 131 to 140 of about 1,273,827 (295)

The synthetic cannabinoids menace: a review of health risks and toxicity

open access: yesEuropean Journal of Medical Research
Synthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe enough to damage the normal ...
Ayman Alzu’bi   +5 more
doaj   +1 more source

Cardiotoxicity of new psychoactive substances – A review of experimental studies and real clinical and forensic cases

open access: yesAnnales Academiae Medicae Silesiensis
Designer drugs pose a serious modern health threat, specially the two most popular groups: synthetic cannabinoids and synthetic cathinones. Most of the available literature focuses on the neurological effects and scarcely describes effects on the ...
Rafał Skowronek, Alexander Suchodolski
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

National Campaign Against Drug Abuse Social Issues Survey, 1993

open access: yes, 2019
This study is the fourth in a series of national household surveys to examine current attitudes towards drugs and drug problems, usage of drugs, and to assess changes in these attitudes and usage over the period 1985-1993.
Drugs of Dependence Branch
core   +1 more source

Determinação de designer drugs em saliva por paper spray mass spectrometry

open access: yesQuímica Nova
Determination of two drugs of abuse in saliva has been performed by Paper Spray Ionization Mass Spectrometry (PSI-MS) using a Molecularly Imprinted Polymer (MIP) coated paper as substrate.
Lanaia Ítala L. Maciel   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

National Drugs Advisory Board annual report, 1990.

open access: yes, 1990
The National Drugs Advisory Board was established by the Minister for Health in 1966 by the National Drugs Advisory Board (Establishment) Order 1966 (5.1. No.163 of 1966) under the Health (Corporate Bodies) Act 1961.
National Drugs Advisory Board (NDAB)
core  

A visão empresarial sobre o designer na indústria moveleira: um elemento agregador de valor [PDF]

open access: yes, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.Esta pesquisa procurou verificar a visão do empresário acerca do papel que o designer exerce junto à indústria ...
Luza, Rosilene Przydzimirski
core  

Opioid-like designer drugs: A practical review of detection, confirmation and interpretation

open access: yesJournal of Pharmaceutical and Biomedical Analysis Open
Opioid-like designer drugs are a rapidly evolving subset of new psychoactive substances (NPS), potent synthetic opioids that increasingly challenge established toxicological and forensic workflows.
Michele Protti   +7 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

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