Results 111 to 120 of about 16,272 (302)
Designer drugs: spice and bath salts
, 2016 Discusses the dangers of designer drugs, including the target audience and marketing and purchasing of the ...
Koukel, Sonja;
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Annales Academiae Medicae SilesiensisDesigner drugs pose a serious modern health threat, specially the two most popular groups: synthetic cannabinoids and synthetic cathinones. Most of the available literature focuses on the neurological effects and scarcely describes effects on the ...
Rafał Skowronek, Alexander Suchodolski
doaj +1 more source
Investigate the Effects of Designer Drugs on Amyloid Beta
, 2020 Designer drugs are structurally novel compounds that can exhibit several pharmacodynamic effects. The diverse pharmacodynamic effects of designer drugs are due to their significant interaction with the major drug targets in the body. The designer drugs
Harshan, Aishah
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Designer Receptors Exclusively Activated by Designer Drugs Approach to Treatment of Sleep-disordered Breathing. [PDF]
Am J Respir Crit Care Med, 2021 Fleury Curado T +17 more
europepmc +1 more source
, 2015 Designer steroids are the world leading performance enhancing drug, they are effective and undetectable which is what athletes look for. WADA is in a rat race to find ways to detected this drugs, such as Tetrahydrogestrinone and other likes it ...
Gruber, Naama
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Filter Feature Selection for Unsupervised Clustering of Designer Drugs Using DFT Simulated IR Spectra Data. [PDF]
ACS Omega, 2021 He K.
europepmc +1 more source
Psychological disorders related to designer drugs
, 2000 Examines the history, nature, effects, and dangers of such designer drugs as Ecstasy, PCP, fentanyl, and ...
Connelly, Elizabeth Russell
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