Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
National Drugs Advisory Board annual report, 1990.
, 1990 The National Drugs Advisory Board was established by the Minister for Health in 1966 by the National Drugs Advisory Board (Establishment) Order 1966 (5.1. No.163 of 1966) under the Health (Corporate Bodies) Act 1961.
National Drugs Advisory Board (NDAB)
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Designer drugs pose a severe public danger after hospitalisation of six.
, 2016 The hospitalisation of six people after allegedly taking 2C-B is a prime example of the potential dangers of consuming a so-called designer drug....
Keating, Dr U
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Detection of Drugs of Abuse by Raman Spectroscopy [PDF]
, 2010 Raman spectroscopy can provide rapid, sensitive, non-destructive analysis of a variety of drug types (e.g. amphetamines, alkaloids, designer drugs and date rape drugs). This review concentrates on developments in the past 15 years.
West, M.J. +3 more
core +1 more source
Correction to: Pharmacological affinity fingerprints derived from bioactivity data for the identification of designer drugs. [PDF]
J Cheminform, 2022 He K.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
National Drugs Advisory Board annual report, 1986
, 1986 The National Drugs Advisory Board was established by the Minister for Health in 1966 by the National Drugs Advisory Board (Establishment) Order 1966 (5.1. No. 163·of 1966) under the Health (Corporate Bodies) Act 1961.
National Drugs Advisory Board (NDAB)
core
The emergent roles of a designer in the development of an e learning service [PDF]
, 2009 This paper presents reflections from a service design case study and uses it to investigate the emerging roles of a designer. Skills, methodologies and values are drawn through the case study and used to communicate how this contributes to the continuing
Yee, Joyce +2 more
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source