Results 101 to 110 of about 16,272 (302)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Correction to: Pharmacological affinity fingerprints derived from bioactivity data for the identification of designer drugs. [PDF]
J Cheminform, 2022 He K.
europepmc +1 more source
Designer Drugs: Uncertain Borders
, 2008 Hallucinogenic plants may be the oldest drugs in the world, and were probably used in rituals during prehistoric times. In the 20th century, LSD and ecstasy became the hallucinogens of choice.
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Rapid Targeted Method of Detecting Abused Piperazine Designer Drugs. [PDF]
J Clin Med, 2021 Welz A +3 more
europepmc +1 more source
Designer drugs : analytical and biological aspects [PDF]
, 2012 In the recent years, analytical toxicologists have been facing difficulties in detecting designer drugs due to the chemical modifications on the existing structures and the speed in which they are released into the market, requiring the development and ...
Bulcão, Rachel Picada +7 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Pharmacological affinity fingerprints derived from bioactivity data for the identification of designer drugs. [PDF]
J Cheminform, 2022 He K.
europepmc +1 more source
National Campaign Against Drug Abuse Social Issues Survey, 1993
, 2019 This study is the fourth in a series of national household surveys to examine current attitudes towards drugs and drug problems, usage of drugs, and to assess changes in these attitudes and usage over the period 1985-1993.
Drugs of Dependence Branch
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source