Results 91 to 100 of about 1,197,649 (297)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
‘Designer drugs’ being sold as ‘bath salts’ and ‘spice’ causing concern.
, 2013 NEW DRUGS MARKETED as “legal highs” and “designer drugs” are emerging fast and in great numbers, and authorities are struggling to keep up, a new UN report warned today. So-called new psychoactive substances (NPS), often sold under harmless names like
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
‘No limit’ to new designer drugs.
, 2016 There are “virtually no limitations” to the range of chemicals used to produce so-called new psychoactive drugs, the world’s drug law watchdog (INCB) has said..........
O'Keeffe, Cormac
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Drug Design and Drug Discovery
International Journal of Innovative Science and Research Technology (IJISRT)One of the key forces influencing the advancement of pharmaceuticals, biotechnology, and pharmacology is the drug industry. The process of finding and creating medications is known as drug discovery. It is a procedure designed to find a substance that has therapeutic value in treating and curing illness.
Aditya Maurya +4 more
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Reports of side effects associated with the use of drugs 1991 [PDF]
, 1991 In order that drugs for therapeutic use should be given under the best and safest circumstances, it is important that practitioners be aware of potential hazards in their use.
National Drugs Advisory Board (NDAB)
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Correction to: Designer drugs: mechanism of action and adverse effects. [PDF]
Arch Toxicol, 2022 Luethi D, Liechti ME.
europepmc +1 more source