Results 51 to 60 of about 94,577 (347)
Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]
, 2017 The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R +7 more
core +2 more sources
Rational Drug Design Rational Drug Design
, 2017 For the past three decades rationale drug design (RDD) has been developing as an innovative, rapid and successful way to discover new drug candidates. Many strategies have been followed and several targets with diverse structures and different biological roles have been investigated. Despite the variety of computational tools available, one can broadly
Khaled H. Barakat +3 more
openaire +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga +56 more
wiley +1 more source
DREADDs in Epilepsy Research: Network-Based Review
Frontiers in Molecular Neuroscience, 2022 Epilepsy can be interpreted as altered brain rhythms from overexcitation or insufficient inhibition. Chemogenetic tools have revolutionized neuroscience research because they allow “on demand” excitation or inhibition of neurons with high cellular ...
John-Sebastian Mueller +2 more
doaj +1 more source
Comparative study of design: application to Engineering Design [PDF]
, 2005 A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops.
Blackwell, A. +8 more
core +1 more source
Association between illegal drugs and weapon carrying in young people in Scotland: schools' survey [PDF]
, 2000 OBJECTIVES: To identify the type and extent of weapons being carried among young people in Scotland, and to determine the relation between use of illegal drugs and weapon carrying. DESIGN: Questionnaire school survey.
McKeganey, N., Norrie, J.
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard +8 more
wiley +1 more source
Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
Molecules, 2019 Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using experimental and theoretical methods. Their binding to μOR was assessed with radioligand competitive binding assay.
Piotr F. J. Lipiński +8 more
doaj +1 more source
Protocol for behavioral tests using chemogenetically manipulated mice
STAR Protocols, 2021 Summary: Behavioral analyses using mice chemogenetically manipulated by designer receptors exclusively activated by designer drugs (DREADDs) are powerful tools to elucidate neural functions.
Noriko Horii-Hayashi, Mayumi Nishi
doaj +1 more source
Pharmacology of novel psychoactive substances [PDF]
, 2016 This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core +1 more source