Results 41 to 50 of about 16,272 (302)

High-potency ligands for DREADD imaging and activation in rodents and monkeys

open access: yesNature Communications, 2019
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks.
Jordi Bonaventura   +24 more
doaj   +1 more source

Pharmacological aspect of novel illicit designer drugs

open access: yes, 2023
this thesis explains the latest in the designer drugs and stresses the importance and mechanism of action of how to deal with themegységes, osztatlanáltalános ...
Abou Assali, Ameer
core  

Roar of meow-meow (mephedrone) in India

open access: yesJournal of Mental Health and Human Behaviour, 2015
Recently, a dangerous new designer drug mephedrone has fast gained popularity among the youth and teens of India. Its abuse has soared to mount to an epidemic.
Pooja Yudhishthir Palkar   +1 more
doaj   +1 more source

Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays

open access: yesFrontiers in Neuroscience, 2020
Synthetic cathinones are the second largest class of new psychoactive substances (NPS) on the drug market. Despite the large number of different cathinones and their abundant use, hazard characterization is mainly limited to their potential to inhibit ...
Anne Zwartsen   +4 more
doaj   +1 more source

Clinical pattern of poisoning among patients declared as taking novel recreational drugs

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2020
Objectives Intoxication with novel psychoactive drugs poses a significant challenge for medicine due to diagnostic difficulties, complex clinical patterns resulting from the polyethiology of poisoning, and the risk of fatal complications.
Anna Krakowiak   +3 more
doaj   +1 more source

Beyond THC: the new generation of cannabinoid designer drugs

open access: yesFrontiers in Behavioral Neuroscience, 2011
Synthetic cannabinoids are functionally similar to delta9-tetrahydrocannabinol (THC), the psychoactive principle of cannabis, and bind to the same cannabinoid receptors in the brain and peripheral organs.
Liana eFattore   +3 more
doaj   +1 more source

Piperazine derivatives as dangerous abused compounds

open access: yesActa Pharmaceutica, 2020
Piperazine derivatives are a group of compounds with a psychostimulant effect. They are an alternative to illegal drugs. They are being searched for recreational use due to their psychoactive and hallucinogenic effects.
Welz Anna, Koba Marcin
doaj   +1 more source

Monitoring risk behaviour in adolescent pupils regarding consumption of psychoactive substances

open access: yesAnnals of Agricultural and Environmental Medicine, 2017
Introduction Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. Objectives To estimate the amount and incidence of drug consumption in middle and high school pupils ...
Paulina Wojtyła-Buciora   +8 more
doaj   +1 more source

Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects

open access: yesNeurology International, 2022
As tranquilizers, benzodiazepines have a wide range of clinical uses. Recently, there has been a significant rise in the number of novel psychoactive substances, including designer benzodiazepines.
Amber N. Edinoff   +9 more
doaj   +1 more source

Acute health problems due to recreational drug use in patients presenting to an urban emergency department in Switzerland [PDF]

open access: yes, 2015
QUESTIONS UNDER STUDY: To describe acute toxicity of recreational drugs including novel psychoactive substances. METHODS: We included all cases presenting at the emergency department (ED) of the University Hospital of Basel, Switzerland, between ...
Dolder, Patrick C.   +9 more
core   +1 more source

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