Results 21 to 30 of about 1,273,827 (295)
Occurrence of Takotsubo Cardiomyopathy after Synthetic Cannabinoid Consumption [PDF]
Addiction and Health, 2019 Background: Synthetic cannabinoid use such as “K2” and “Spice” is popular secondary to its inability to be detected in a urine drug screen. It is associated with a wide range of myocardial pathologies including obstructive and non-obstructive coronary ...
Denelle Mohammed
doaj +1 more source
The DREADDful Hurdles and Opportunities of the Chronic Chemogenetic Toolbox
Cells, 2022 The chronic character of chemogenetics has been put forward as one of the assets of the technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic studies have focused on acute applications, while repeated, long-term ...
Marie Claes, Lies De Groef, Lieve Moons
doaj +1 more source
Oneiroid catatonia due to the usage of spice: The case study
European Psychiatry, 2021 Introduction Designer drugs, as a term, first came about in the 1980s. Most of these “designer drugs” have synthetic cannabinoids and other psychoactive formulas difficulty to detect. Objectives A 28 year man was referred to the hospital.
O. Pityk +4 more
doaj +1 more source
Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards [PDF]
Journal of the Serbian Chemical Society, 2008 The use of gas chromatography–mass spectrometry (GC–MS) in forensic analysis is increasing. To exploit fully the capabilities of MS, labeled standards, that can be used to improve the performance of the quantitative analysis, and to increase accuracy and
YA-ZHU XU +3 more
doaj +3 more sources
„Dopalacze” – nieprzewidywalne narkotyki. Problem społeczno-prawny
Filozofia Publiczna i Edukacja Demokratyczna, 2019 The aim of this article is to present the problem of new psychoactive substances – designer drugs. New drugs are undoubtedly a social and legal problem.
Sebastian Matyjek
doaj +1 more source
Bio-Protocol, 2023 Recent advancements in chemogenetic tools, such as designer receptors exclusively activated by designer drugs (DREADDs), allow the simultaneous manipulation of activity over a specific, broad brain region in nonhuman primates.
Kei Oyama +2 more
doaj +1 more source
Wytwarzanie lub obrót dopalaczami jako czyn z art. 165 § 1 pkt 2 k.k.
Acta Iuris Stetinensis, 2018 The article discusses the issues of possibility to qualify producing or marketing the designer drugs as an offence form article 165 § 1 point 2 cc. The analysis is subjected primarily to ratio legis of this regulation, which shows that it does not have ...
Magdalena Kowalewska-Łukuć
doaj +1 more source
Sequence-based drug design as a concept in computational drug design
Nature Communications, 2023 Abstract Drug development based on target proteins has been a successful approach in recent decades. However, the conventional structure-based drug design (SBDD) pipeline is a complex, human-engineered process with multiple independently optimized steps.
Lifan Chen +23 more
openaire +3 more sources
Rational Drug Design Paradigms: The Odyssey for Designing Better Drugs
Combinatorial Chemistry & High Throughput Screening, 2015 Due to the time and effort requirements for the development of a new drug, and the high attrition rates associated with this developmental process, there is an intense effort by academic and industrial researchers to find novel ways for more effective drug development schemes.
Kellici T +13 more
openaire +4 more sources
Inventions, 2023 The aim of this research was to develop and deploy efficient deep convolutional neural network (DCNN) frameworks for detecting and discriminating between various categories of designer drugs. These are of particular relevance in forensic contexts, aiding
Catalina Mercedes Burlacu +3 more
doaj +1 more source