Results 51 to 60 of about 93,845 (280)
Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis
Molecules, 2019 Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using experimental and theoretical methods. Their binding to μOR was assessed with radioligand competitive binding assay.
Piotr F. J. Lipiński +8 more
doaj +1 more source
DREADDs in Epilepsy Research: Network-Based Review
Frontiers in Molecular Neuroscience, 2022 Epilepsy can be interpreted as altered brain rhythms from overexcitation or insufficient inhibition. Chemogenetic tools have revolutionized neuroscience research because they allow “on demand” excitation or inhibition of neurons with high cellular ...
John-Sebastian Mueller +2 more
doaj +1 more source
Comparative study of design: application to Engineering Design [PDF]
, 2005 A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops.
Blackwell, A. +8 more
core +1 more source
The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]
, 2019 © 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania +5 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Designers Drugs—A New Challenge to Emergency Departments—An Observational Study in Poland
Medicina, 2020 Background and Objective: In the last decade, the phenomenon of using new psychoactive substances (NPS), called designer drugs, has been on rise. Though their production and marketing in Poland is prohibited, reports of the Supreme Audit Office noted ...
Rakesh Jalali +7 more
doaj +1 more source
Protocol for behavioral tests using chemogenetically manipulated mice
STAR Protocols, 2021 Summary: Behavioral analyses using mice chemogenetically manipulated by designer receptors exclusively activated by designer drugs (DREADDs) are powerful tools to elucidate neural functions.
Noriko Horii-Hayashi, Mayumi Nishi
doaj +1 more source
Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]
, 2015 The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait +23 more
wiley +1 more source
Brackets, epitopes and flash memory cards: a futuristic view of clinical orthodontics
Australasian Orthodontic Journal, 1999 Orthodontics continues to be a profession anchored in traditional technology using appliances that cause inflammatory periodontal ligament (PDL) responses.
Sims Milton R.
doaj +1 more source