Results 121 to 130 of about 18,110 (202)

TRAF7‐Mutated Fibromyxoid Spindle Cell Tumor of Bone: An Osseous Case Expanding the Spectrum of TRAF7‐Mutated Tumors With Over 20 Years Clinical Follow‐Up

Genes, Chromosomes and Cancer, Volume 65, Issue 3, March 2026.
ABSTRACT TRAF7 mutations are a rare occurrence in human cancer and have recently been described in a group of mesenchymal tumors with varying clinical course. Herein, we expand the spectrum of TRAF7‐mutated fibromyxoid spindle cell tumors by reporting the first case to arise in bone.
Laura M. Warmke, Ani Toklu, Spencer M. Richardson, Christopher D. Collier, L. Daniel Wurtz, Lauren M. Ladd, Roman Shrestha, Devin J. Conway   +7 more
wiley   +1 more source

Rapidly Progressive Primary Pulmonary Leiomyosarcoma Diagnosed by Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration: A Case Report

Respirology Case Reports, Volume 14, Issue 3, March 2026.
Primary pulmonary leiomyosarcoma is a rare malignant tumour that is often difficult to diagnose. We report a case that was successfully diagnosed using endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) of a mediastinal lymph node. This case highlights the diagnostic value of EBUS‐TBNA in rare pulmonary sarcomas.
Hayato Yabe, Takumi Nishimaki, Shun Hirabuki, Juri Tsuchimoto, Koutaro Murao, Haruhiko Aisaka   +5 more
wiley   +1 more source

Assessment of myogenic potency in patient-derived fibroblasts with c.1289-2A>G Desmin mutation

Türk Biyokimya Dergisi
The ultra-rare DES c.1289-2A>G mutation, resulting in a 48-base pair insertion in the Desmin tail domain, is associated with late-onset MFM1 (myofibrillar myopathy-1; OMIM number; 601419) and exhibits distinctive pathological features.
Düz Nilüfer, Ünsal Şeyda, Eerdem-Özdamar Sevim, Dinçer Pervin   +3 more
doaj   +1 more source

Viral Pathogens and Pulmonary Fibrosis: EMT‐Driven Mechanisms and Insights From Traditional Chinese Medicine

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a serious progressive complication of the respiratory system, which is profoundly associated with persistent extracellular matrix (ECM) deposition, fibrosis, and disrupted tissue regeneration. Emerging evidence shows that epithelial–mesenchymal transition (EMT) acts as a key factor in the pathogenesis of ...
Ningzi Zang, Yingxu Wu, Pin Li, Yongming Liu, Shiwen Wang, Jiapeng Leng, Libin Zhan, Xiaodong Lyu, Lijian Pang, Jiaran Wang   +9 more
wiley   +1 more source

Immunoreactivity for CD34, Desmin, Keratins, KIT, Alpha‐Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Immunohistochemical expression of CD34, desmin, keratin AE1/AE3, keratin 8/18, KIT, SMA, S100, and vimentin in normal guinea pig skin serving as both positive and negative external tissue control. All images immunohistochemical staining, 200× magnification, scale bar 100 µm. (A) CD34 stained only vascular endothelium (arrow).
Jiří Lenz, Miša Škorič, František Tichý, Luděk Fiala   +3 more
wiley   +1 more source

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, Volume 14, Issue 3, Page 718-735, March 2026.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

Identification of a distinct epigenetic subgroup with inferior PFS in intracranial mesenchymal tumors with FET::CREB fusion

Brain Pathology, Volume 36, Issue 2, March 2026.
Six new cases of intracranial mesenchymal tumors with FET::CREB fusion, alongside 20 previously reported cases underwent DNA methylation profiling uncovered a novel epigenetic subgroup distinguished by inferior PFS and unique clinicopathological, molecular, and epigenetic hallmarks.
Yong Lin, Yun Ning, Yang Lan, Yu‐Juan Cao, Rui‐Jiao Zhao, Hai‐Nan Li, Song Duan, Wei‐Wei Fu, Hai‐Bo Wu, Feng Wu, Xiu‐Wu Bian, Tao Luo, Xiao‐Hong Yao   +12 more
wiley   +1 more source

Targeting SPP1‐CD44‐Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis

Cancer Science, Volume 117, Issue 3, Page 670-682, March 2026.
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka   +16 more
wiley   +1 more source

Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues

Cell Proliferation, Volume 59, Issue 3, March 2026.
H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.
Yuxi Jiang, Yao Shen, Qiongyin Zhang, Zi Liu, Yuzhen Liu, Jiaojiao Peng, Xuesong Yang, Feng Gao, Xiang‐Hong Ou, Qing‐Yuan Sun, Qiao Zhang, Guang Wang   +11 more
wiley   +1 more source

Myotubularine et desmine [PDF]

médecine/sciences, 2011
Karim Hnia, Jocelyn Laporte
openaire   +1 more source