Results 141 to 150 of about 18,110 (202)

Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function.

Journal of Thoracic and Cardiovascular Surgery, 2016
M. Ahmed, Jason L. Guichard, R. Soorappan, Shama Ahmad, N. Mariappan, S. Litovsky, H. Gupta, S. Lloyd, T. Denney, P. Powell, I. Aban, J. Collawn, J. Davies, D. McGiffin, L. Dell’Italia   +14 more
semanticscholar   +1 more source

Desmin Mutation in the C-Terminal Domain Impairs Traction Force Generation in Myoblasts.

Biophysical Journal, 2016
Elisabeth E Charrier, A. Asnacios, R. Milloud, R. de Mets, M. Balland, F. Delort, O. Cardoso, P. Vicart, S. Batonnet-Pichon, S. Hénon   +9 more
semanticscholar   +1 more source

Abnormal Accumulation of Desmin in Gastrocnemius Myofibers of Patients with Peripheral Artery Disease

Journal of Histochemistry and Cytochemistry, 2015
P. Koutakis, Dimitrios Miserlis, S. Myers, J. Kim, Zhen Zhu, Evlampia Papoutsi, S. Swanson, G. Haynatzki, Duy M. Ha, Lauren A Carpenter, R. Mccomb, J. Johanning, G. Casale, I. Pipinos   +13 more
semanticscholar   +1 more source

Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle

Cell Death and Differentiation, 2020
Mitochondria change distribution across cells following a variety of pathophysiological stimuli. The mechanisms presiding over this redistribution are yet undefined.
Matteo Giovarelli, Emanuele Martini, Michela Ripolone   +2 more
exaly   +2 more sources

Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Mutations in the human desmin gene cause myopathies and cardiomyopathies. This study aimed to elucidate molecular mechanisms initiated by the heterozygous R406W-desmin mutation in the ...
Harald Herrmann, Julia Moosmann, Veronika Weyerer   +2 more
exaly   +2 more sources

Molecular insights into cardiomyopathies associated with desmin (DES) mutations

Biophysical Reviews, 2018
Andreas Brodehl, Hendrik Milting
exaly   +2 more sources

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

Circulation Research, 2018
Peter P Rainer, Justyna Fert-Bober, Ronald J Holewinski   +2 more
exaly   +2 more sources

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Protein aggregation and the deposition of amyloid is a common feature in neurodegeneration, but can also be seen in degenerative muscle diseases known as myofibrillar myopathies (MFMs).
Niraja Kedia, Mark Batchelor, Conrad C Weihl   +2 more
exaly   +2 more sources

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Role of calpains in promoting desmin filaments depolymerization and muscle atrophy.

Biochimica et biophysica acta. Molecular cell research, 2020
Muscle atrophy is an inevitable sequel of fasting, denervation, aging, exposure to microgravity, and many human diseases including, cancer, type-2 diabetes, and renal failure.
Shenhav Cohen
semanticscholar   +1 more source

Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020
Desmin, being a major intermediate filament of muscle cells, contributes to stabilization and positioning of mitochondria. Desmin mutations have been reported in conjunction with skeletal myopathies accompanied by mitochondrial dysfunction.
N. Smolina, A. Khudiakov, A. Knyazeva, A. Zlotina, Kseniya Sukhareva, K. Kondratov, V. Gogvadze, B. Zhivotovsky, T. Sejersen, A. Kostareva   +9 more
semanticscholar   +1 more source