Results 11 to 20 of about 72,501 (324)

Desmin Modulates Muscle Cell Adhesion and Migration

Frontiers in Cell and Developmental Biology, 2022
Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator.
Coralie Hakibilen, Florence Delort, Marie-Thérèse Daher, Pierre Joanne, Eva Cabet, Olivier Cardoso, Fany Bourgois-Rocha, Cuixia Tian, Eloy Rivas, Marcos Madruga, Ana Ferreiro, Ana Ferreiro, Alain Lilienbaum, Patrick Vicart, Onnik Agbulut, Sylvie Hénon, Sabrina Batonnet-Pichon   +16 more
doaj   +2 more sources

Desmin Interacts Directly with Mitochondria [PDF]

International Journal of Molecular Sciences, 2020
Desmin intermediate filaments (IFs) play an important role in maintaining the structural and functional integrity of muscle cells. They connect contractile myofibrils to plasma membrane, nuclei, and mitochondria. Disturbance of their network due to desmin mutations or deficiency leads to an infringement of myofibril organization and to a deterioration ...
Dayal, Alexander A., Medvedeva, Natalia V., Nekrasova, Tatiana M., Duhalin, Sergey D., Surin, Alexey K., Minin, Alexander A.   +5 more
openaire   +3 more sources

The N-Terminal Part of the 1A Domain of Desmin Is a Hot Spot Region for Putative Pathogenic DES Mutations Affecting Filament Assembly

Cells, 2022
Desmin is the major intermediate filament protein of all three muscle cell types, and connects different cell organelles and multi-protein complexes such as the cardiac desmosomes. Several pathogenic mutations in the DES gene cause different skeletal and
Andreas Brodehl, Stephanie Holler, Jan Gummert, Hendrik Milting   +3 more
doaj   +2 more sources

Lack of Desmin in Mice Causes Structural and Functional Disorders of Neuromuscular Junctions

Frontiers in Molecular Neuroscience, 2020
Desmin, the major intermediate filament (IF) protein in muscle cells, interlinks neighboring myofibrils and connects the whole myofibrillar apparatus to myonuclei, mitochondria, and the sarcolemma.
Nane Eiber, Franziska Fröb, Mirjam Schowalter, Christian Thiel, Christian Thiel, Christoph S. Clemen, Christoph S. Clemen, Christoph S. Clemen, Rolf Schröder, Rolf Schröder, Said Hashemolhosseini, Said Hashemolhosseini   +11 more
doaj   +2 more sources

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells ...
Arhzaouy, Khalid, Batchelor, Mark, Bieschke, Jan, Kedia, Niraja, Pittman, Sara K., Sun, Yuanzi, Weihl, Conrad C.   +6 more
core   +3 more sources

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene

Biology Open, 2016
The transcription factor Nkx2.5 and the intermediate filament protein desmin are simultaneously expressed in cardiac progenitor cells during commitment of primitive mesoderm to the cardiomyogenic lineage.
Christiane Fuchs, Sonja Gawlas, Philipp Heher, Sofia Nikouli, Hannah Paar, Mario Ivankovic, Martina Schultheis, Julia Klammer, Teresa Gottschamel, Yassemi Capetanaki, Georg Weitzer   +10 more
doaj   +2 more sources

Desminopathy: Novel Desmin Variants, a New Cardiac Phenotype, and Further Evidence for Secondary Mitochondrial Dysfunction [PDF]

Journal of Clinical Medicine, 2020
Background: The pleomorphic clinical presentation makes the diagnosis of desminopathy difficult. We aimed to describe the prevalence, phenotypic expression, and mitochondrial function of individuals with putative disease-causing desmin (DES) variants ...
Miloš Kubánek, Tereza Schimerová, Lenka Piherová, Andreas Brodehl, Alice Krebsová, Sandra Ratnavadivel, Caroline Stanasiuk, Hana Hansíková, J Zeman, Tomáš Paleček, J Houštěk, Z Drahota, Hana Nůsková, Jana Mikešová, Josef Zámečnı́k, Milan Maçek, Petr Ridzoň, Jana Malušková, Viktor Stránecký, Vojtěch Melenovský, Hendrik Milting, Stanislav Kmoch   +21 more
openalex   +2 more sources

Transcription factor EB activation rescues advanced αB-crystallin mutation-induced cardiomyopathy by normalizing desmin localization [PDF]

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autophagy ...
Benjamin, Ivor J, Diwan, Abhinav, Foroughi, Layla, French, Brent A, Hill, Joseph A, Javeheri, Ali, Kovacs, Attila, Kraja, Aldi, Liu, Haiyan, Ma, Xiucui, Mani, Kartik, Murphy, John T, Weinheimer, Carla J   +12 more
core   +3 more sources

New roles for desmin in the maintenance of muscle homeostasis

The FEBS Journal, 2021
Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force ...
G. Agnetti, H. Herrmann, Shenhav Cohen
semanticscholar   +1 more source

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Biomedicines, 2022
The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative stress,
A. Dawood, Norah M Alzamil, P. Hewett, M. Momenah, M. Dallak, S. Kamar, Dina H Abdel Kader, Hanaa Z Yassin, M. Haidara, A. Maarouf, B. Al‐Ani   +10 more
semanticscholar   +1 more source