Results 61 to 70 of about 10,060 (207)

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Calcium-Dependent Conformation of Desmoglein 1 Is Required for its Cleavage by Exfoliative Toxin [PDF]

, 2003
In bullous impetigo, Staphylococcus aureus spreads under the stratum corneum of skin by elaboration of exfoliative toxin, which hydrolyzes only one peptide bond in a highly structured calcium-binding domain of desmoglein 1, resulting in loss of its ...
Stanley, John R., Schechter, Norman M., Hanakawa, Yasushi, Woo, Denise, Lin, Chenyan, Selwood, Trevor   +5 more
core   +1 more source

Reassessing Remission in Pemphigus Vulgaris: Beyond Complete Remission Towards Meaningful Disease Control

International Journal of Dermatology, EarlyView.
ABSTRACT Current remission criteria for pemphigus vulgaris rely on binary, lesion‐based endpoints that do not capture immunological status, treatment toxicity, or patient quality of life. We argue for a multidimensional framework incorporating minimal disease activity, validated severity scores, glucocorticoid toxicity indices, and patient‐reported ...
Rhea Ahuja, Sumin Hong, Dédée F. Murrell   +2 more
wiley   +1 more source

Incidence of P200 pemphigoid: A nationwide study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The anti‐LAMB4 cell‐based immunoassay is a new serological technique that is far superior to dermal immunoblotting for detecting autoantibodies directed against the P200 protein. This method allows a re‐evaluation of the incidence of P200 pemphigoid, which appears to be considerably more frequent than epidermolysis bullosa acquisita.
Fabienne Jouen, Marion Carrette, Marie‐Laure Golinski, Maud Maho‐Vaillant, Alexis Lefebvre, André Gillibert, Pascal Joly, Vivien Hébert   +7 more
wiley   +1 more source

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Colocalization of desmoglein-2 and integrin-beta8 in N-MVECs.

, 2013
A) Immunostaining of N-MVECs with anti-desmoglein-2 and anti-integrin-beta8 antibodies (nuclei stained with DAPI) in a single N-MVEC (upper row) and in a group of N-MVECs (lower row).
Simona Serratì (220041), Anna Laurenzana (296271), Luciana Rossi (432765), Betti Giusti (74939), Francesca Margheri (296258), Lido Calorini (296275), Ilaria Lapini (432766), Rosanna Abbate (74947), Lucia Magnelli (296267), Anastasia Chillà (296269), Francesca Bianchini (296273), Gabriella Fibbi (296278), Mario Del Rosso (296279), Alberto Magi (155404)   +13 more
core   +1 more source

IgA pemphigus showing IgA antibodies to desmoglein 1 and 3

Dermatology Practical & Conceptual, 2016
Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
Salama Hegazy, Sana Bouchouicha, Aida Khaled, Lilia Laadher, Maryem Kallel Sellami, Faten Zeglaoui   +5 more
doaj   +1 more source

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Asian Pacific Journal of Cancer Prevention, 2014
Desmogleins (DSGs) are major members among the desmosomal cadherins critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. Reports exploring links of DSG family member expression with cancers are few and vary.
Wang-Kai, Fang, Wei, Gu, Lian-Di, Liao, Bo, Chen, Zhi-Yong, Wu, Jian-Yi, Wu, Jian, Shen, Li-Yan, Xu, En-Min, Li   +8 more
openaire   +3 more sources

CD4+ T Cells Predict Relapse in Pemphigus Vulgaris Treated With Rituximab: A Retrospective Study

Oral Diseases, EarlyView.
ABSTRACT Objective This study evaluated the CD4+ T‐cell role in mediating post‐Rituximab Pemphigus vulgaris (PV) relapse, comparing CD4+ count and CD4+/CD20+ ratio between patients who achieved remission and those who relapsed. Methods The clinical course of 27 PV patients treated with Rituximab was evaluated after a 32‐month median follow‐up. CD4+ and
Simone Liguori, Noemi Coppola, Elvira Ruoppo, Federica Canfora, Gabriele Mignogna, Ilaria Mormile, Antonia Fiore, Giuseppe Castaldo, Michele Davide Mignogna, Stefania Leuci   +9 more
wiley   +1 more source

Monilethrix Presenting With Diffuse Fragile Hair in an Adult Female

JEADV Clinical Practice, EarlyView.
Mandy Robertson, Jeffrey Donovan
wiley   +1 more source