Results 61 to 70 of about 14,267 (224)

Desmogleins: Hair perspective

International Journal of Trichology, 2013
Desmogleins (Dsgs) are calcium-dependent, transmembrane glycoproteins belonging to the desmosomal cadherin superfamily, which play significant roles in selective calcium ions (Ca(2+)) dependent adhesion interactions between cell surfaces. Four subtypes of Dsg have been identified.
openaire   +3 more sources

Rituximab - Progress but Still Not a Final Resolution for Pemphigus Patients: Clinical Report From a Single Center Study

Frontiers in Immunology, 2022
Pemphigus is a rare autoimmune disease characterized by the production of pathogenic autoantibodies against desmosomal adhesion proteins, desmoglein 1 and 3.
Joško Miše, Ines Lakoš Jukić, Ines Lakoš Jukić, Branka Marinović, Branka Marinović   +4 more
doaj   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

Brazilian Journal of Medical and Biological Research, 2001
The LISP-I human colorectal adenocarcinoma cell line was isolated from a hepatic metastasis at the Ludwig Institute, São Paulo, SP, Brazil. The objective of the present study was to isolate morphologically different subpopulations within the LISP-I cell ...
A.C.C. Solimene, C.R.W. Carneiro, I. Melati, J.D. Lopes   +3 more
doaj   +1 more source

Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. [PDF]

, 2010
An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression.
Amengual, J., Bonet, M.L., Bunschoten, A., Godschalk, R.W.L., Heil, S.G., Helden, Y.G.J., Hessel, S., Keijer, J., Lintig, J., von, Schooten, F.J., van   +9 more
core   +2 more sources

Characterization of Desmoglein-3 Epitope Region Peptides as Synthetic Antigens: Analysis of their in vitro T-cell Stimulating Efficacy, Cytotoxicity, Stability and their Conformational Features [PDF]

, 2015
Desmoglein-3 (Dsg3) adhesion protein is the main target of autoantibodies and autoreactive T cells in Pemphigus vulgaris (PV) autoimmune skin disorder.
Ahmed, Ahmed, Amagai, Amagai, Amber, Anhalt, Berkower, Carmicle, Chou, Delva, Dworschak, Enyedi, Estaquier, Ferrante, Green, Gómara, Hashimoto, Hertl, Holly, Hollósi, Jurcevic, Lin, Mahoney, Manning, Meager, Moesta, Mosmann, Partidos, Povey, Rammensee, Riechers, Ruocco, Sathyanarayana, Scharf, Scharf, Schiltz, Shanmugam, Siddiqui, Siligardi, Slater, Stanley, Sz, Szabados, Thomason, Toniolo, Vass, Veldman, Watts, Wheeler, Woody, Woody, Wucherpfennig, Wucherpfennig, Yang   +53 more
core   +1 more source

Successful Treatment of Severe Adult Linear IgA Dermatosis Using Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Linear IgA dermatosis (LAD) is a rare autoimmune subepidermal bullous dermatosis, characterised by the presence of erythematous vesiculobullous lesions arranged in rosettes or herpetiform clusters. The standard treatment involves the administration of dapsone, followed by sulfasalazine, and general corticosteroid therapy, often in combination ...
Célia Delesalle, Claire Abasq‐Thomas, Claire Bocciarelli, Amélie Bourhis, Marina Alexandre, Belen Eguia, Laurent Misery, Numa Deydier   +7 more
wiley   +1 more source

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens

Frontiers in Immunology, 2012
The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance.
Xiaoping eWang, Martti eLaan, Rudolf eBichele, Kai eKisand, Hamish S Scott, Hamish S Scott, Pärt ePeterson   +6 more
doaj   +1 more source

Therapeutic Options for IgA Pemphigus in Patients Refractory to Dapsone

JEADV Clinical Practice, Volume 5, Issue 2, Page 415-424, June 2026.
ABSTRACT IgA pemphigus is a rare autoimmune blistering disorder with limited therapeutic guidance available due to its rarity and complex presentation. This comprehensive analysis evaluates the therapeutic outcomes of 67 published patients, emphasising the significant role of dapsone as the first‐line treatment.
Lorenz Frasheri, Marta Dechant, Tilo Biedermann   +2 more
wiley   +1 more source

Paraneoplastic pemphigus: insight into the autoimmune pathogenesis, clinical features and therapy [PDF]

, 2017
Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients.
Andrea Ciofalo, Biagio Didona, Bialy-Golan, Dario Didona, Elisa Moliterni, Giannicola Iannella, Giovanni Paolino, Giuseppe Magliulo, Guido Granata, Hainsworth, Martínez De Pablo, Matz, Michele Donati, Mutasim, Nguyen, Patricia Ranuzzi, Santo Mercuri, Schepens, Stefano Calvieri, Su, Vincenzo Falasca, Zimmermann   +21 more
core   +2 more sources