Results 1 to 10 of about 13,148 (221)

Desmosome assembly and disassembly are membrane raft-dependent. [PDF]

PLoS ONE, 2014
Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament ...
Sara N Stahley, Masataka Saito, Victor Faundez, Michael Koval, Alexa L Mattheyses, Andrew P Kowalczyk   +5 more
doaj   +2 more sources

Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions [PDF]

JACC: Basic to Translational Science
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death.
J. Alex Aycinena, MS, Anley E. Tefera, PhD, Isaac Perea-Gil, PhD, Duncan Holbrook-Smith, PhD, Kevin Williams, PhD, Reva Shenwai, MS, Farshad Farshidfar, PhD, Brendan Ryback, PhD, Katelyn Foppe, MS, Iris Wu, BS, Aliya Zeng, BS, Melissa Van Pell, BS, Emma Xu, PhD, Joseph Woods, BS, Samantha Jones, MBA, Yolanda Hatter, BS, Cristina Dee-Hoskins, BS, Jessie Madariaga, BS, Kevin Robinson, BS, Amara Greer-Short, PhD, Xiaomei Song, PhD, Kathryn N. Ivey, PhD, James Priest, MD, Gretchen Argast, PhD, Timothy Hoey, PhD, Edward Driggers, PhD, Zhihong Jane Yang, PhD   +26 more
doaj   +2 more sources

Hirudin suppresses hematogenous metastasis by targeting desmosome junction transition in circulating tumor cell clusters via HIF-1α–DSG2 signaling [PDF]

Experimental and Molecular Medicine
s Circulating tumor cell (CTC) clusters, key in metastasis, rely on intercellular junctions for stability. However, the specific mechanisms governing intercellular connections within CTC clusters and the strategy targeting intercellular junctions to ...
Jueyao Zou, Junfeng Shi, Qiong Chen, Ziyan Zhu, Tongyao Hu, Zhengyu Zhang, Zhiqiang Pan, Fei Xu, Yong Zhu, Yuanyuan Wu, Yang Zhao, Aiyun Wang, Yin Lu, Yanhong Pan, Wenxing Chen   +14 more
doaj   +2 more sources

Epicardial Abnormalities and Mesenchymal/Hematopoietic Cell Expansion in Plakophilin 2-Null Mouse Embryonic Hearts [PDF]

Cells
Desmosomal junctions provide structural stability supporting concerted cardiomyocyte contractility. Previously, we demonstrated that a deficiency in the desmosomal transmembrane cadherin desmoglein 2 (Dsg2) reduces desmosome formation and disrupts ...
Mistura Dolapo Bolaji, Pia E. Hartmann, Eva Miriam Buhl, Robin M. W. Colpaert, Francesca Gasparella, Leon J. de Windt, Martina Calore, Rudolf E. Leube, Hoda Moazzen   +8 more
doaj   +2 more sources

The impact of signaling pathways on the desmosome ultrastructure in pemphigus [PDF]

Frontiers in Immunology
IntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Thomas Schmitt, Julia Huber, Julia Pircher, Enno Schmidt, Enno Schmidt, Jens Waschke   +5 more
doaj   +2 more sources

Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions [PDF]

Nature Communications
Epidermal stem cells interact with the extracellular matrix (ECM) to regulate their differentiation and maintain skin architecture. Here, we demonstrate a role for basal epidermal stem cells (BECs)-ECM interaction in regulating adhesion molecules ...
Helen Mengze He, Liana C. Boraas, Jon M. Bell, Xiangyu Gong, Sophia L. Iannaccone, Zhang Wen, Michael Mak, Marina Carlson, Kaelyn Sumigray, Stefania Nicoli   +9 more
doaj   +2 more sources

Dsg2 ectodomain organization increases throughout desmosome assembly

Cell Adhesion and Migration
Desmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mechanisms governing junction assembly remain elusive.
William F Dean, Tomasz Nawara, Alexa L Mattheyses   +2 more
exaly   +3 more sources

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin

Frontiers in Immunology, 2022
Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3.
Desalegn Tadesse Egu, Thomas Schmitt, Jens Waschke   +2 more
doaj   +1 more source

Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

Frontiers in Cell and Developmental Biology, 2021
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Lisa Müller, Mechthild Hatzfeld, René Keil   +2 more
doaj   +1 more source

EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation

JCI Insight, 2023
Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options.
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kääb, Sebastian Clauss, Dominik Schüttler, Jens Waschke, Sunil Yeruva   +13 more
doaj   +1 more source