Results 1 to 10 of about 7,464 (117)
Biology, 2023 Background: Pemphigus is a life-threatening blistering autoimmune disease. Several forms, characterized by the presence of autoantibodies against different autoantigens, have been described.
Emma Dorotea Zanfi +2 more
exaly +3 more sources
Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]
BMC Oral HealthBackground Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood +3 more
doaj +2 more sources
Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus
Frontiers in Immunology, 2018 Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly ...
Thomas Magin +2 more
exaly +3 more sources
Desmoglein autoantibodies and disease severity in pemphigus patients – correlations and discrepancies [PDF]
Folia Medica, 2023 Aim: To assess the correlation between the levels of anti-desmoglein-1 and anti-desmoglein-3 autoantibodies and disease severity in pemphigus patients.
Zhaneta H. Zhelyazkova +4 more
doaj +3 more sources
Frontiers in Immunology, 2023 Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić +4 more
doaj +1 more source
Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. [PDF]
PLoS ONE, 2014 During development and progression of malignant melanoma, an important role has been attributed to alterations of cell-cell adhesions, in particular, to a "cadherin switch" from E- to N-cadherin.
Wiebke K Peitsch +7 more
doaj +1 more source
Frontiers in Immunology, 2021 Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact
Tamara Moreno-Sosa +14 more
doaj +1 more source
Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study
Van Tıp Dergisi, 2021 INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 While classic cadherin-actin connections in adherens junctions (AJs) have ancient origins, intermediate filament (IF) linkages with desmosomal cadherins arose in vertebrate organisms.
Kathleen J. Green +13 more
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Detection of anti-desmoglein antibodies in oral lichen planus: What do we know so far
Frontiers in Immunology, 2022 Oral lichen planus (OLP) is an inflammatory disease of the oral mucosa. Clinically, two main subsets are described, namely non-erosive and erosive OLP. While non-erosive OLP is usually responsive to local therapies, erosive OLP is often refractory also ...
Dario Didona, Michael Hertl
doaj +1 more source