Results 1 to 10 of about 10,060 (207)
Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]
Journal of Investigative Dermatology, 2002 The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Koji Sayama +2 more
exaly +5 more sources
Desmoglein autoantibodies and disease severity in pemphigus patients – correlations and discrepancies [PDF]
Folia Medica, 2023 Aim: To assess the correlation between the levels of anti-desmoglein-1 and anti-desmoglein-3 autoantibodies and disease severity in pemphigus patients.
Zhaneta H. Zhelyazkova +4 more
doaj +5 more sources
Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. [PDF]
PLoS ONE, 2014 During development and progression of malignant melanoma, an important role has been attributed to alterations of cell-cell adhesions, in particular, to a "cadherin switch" from E- to N-cadherin.
Wiebke K Peitsch +7 more
doaj +2 more sources
Biology, 2023 Background: Pemphigus is a life-threatening blistering autoimmune disease. Several forms, characterized by the presence of autoantibodies against different autoantigens, have been described.
Emma Dorotea Zanfi +2 more
exaly +3 more sources
Frontiers in Immunology, 2023 Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić +4 more
doaj +2 more sources
Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus
Frontiers in Immunology, 2018 Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly ...
Thomas Magin +2 more
exaly +3 more sources
Frontiers in Immunology, 2021 Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact
Tamara Moreno-Sosa +14 more
doaj +1 more source
Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study
Van Tıp Dergisi, 2021 INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın +3 more
doaj +1 more source
Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]
Archives of Dermatology, 1999 To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
K, Ishii +8 more
openaire +2 more sources
Identification of Desmogleins as Disease Targets [PDF]
Journal of Investigative Dermatology, 2007 While it had long been known that desmosomes were crucial for interconnecting cells in laboratory experiments, the link between desmosomal adhesion and human health was bolstered by several key experiments demonstrating that desmogleins were targeted in both autoimmune and infectious diseases.
Simpson, Cory L., Green, Kathleen J.
openaire +3 more sources