Results 21 to 30 of about 14,267 (224)

The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function

Frontiers in Cell and Developmental Biology, 2022
While classic cadherin-actin connections in adherens junctions (AJs) have ancient origins, intermediate filament (IF) linkages with desmosomal cadherins arose in vertebrate organisms.
Kathleen J. Green, Kathleen J. Green, Kathleen J. Green, Carien M. Niessen, Carien M. Niessen, Carien M. Niessen, Matthias Rübsam, Matthias Rübsam, Matthias Rübsam, Bethany E. Perez White, Bethany E. Perez White, Joshua A. Broussard, Joshua A. Broussard, Joshua A. Broussard   +13 more
doaj   +1 more source

Detection of anti-desmoglein antibodies in oral lichen planus: What do we know so far

Frontiers in Immunology, 2022
Oral lichen planus (OLP) is an inflammatory disease of the oral mucosa. Clinically, two main subsets are described, namely non-erosive and erosive OLP. While non-erosive OLP is usually responsive to local therapies, erosive OLP is often refractory also ...
Dario Didona, Michael Hertl
doaj   +1 more source

Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis In Vitro and In Vivo

Frontiers in Immunology, 2022
Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease associated with underlying neoplasms and characterized by antibodies against desmoglein 3 (Dsg 3) and plakins.
Xue Wang, Xue Wang, Xue Wang, Xue Wang, Rui Wang, Rui Wang, Rui Wang, Dingfang Bu, Leyi Wang, Leyi Wang, Leyi Wang, Yuexin Zhang, Yuexin Zhang, Yuexin Zhang, Yuan Chang, Yuan Chang, Yuan Chang, Chenyang Zhang, Chenyang Zhang, Xixue Chen, Xixue Chen, Xixue Chen, Xuejun Zhu, Xuejun Zhu, Xuejun Zhu, Zhi Liu, Mingyue Wang, Mingyue Wang, Mingyue Wang   +28 more
doaj   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Identification of Desmogleins as Disease Targets [PDF]

Journal of Investigative Dermatology, 2007
While it had long been known that desmosomes were crucial for interconnecting cells in laboratory experiments, the link between desmosomal adhesion and human health was bolstered by several key experiments demonstrating that desmogleins were targeted in both autoimmune and infectious diseases.
Simpson, Cory L., Green, Kathleen J.
openaire   +3 more sources

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]

, 2016
Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir, Banning, Antje, Eming, Rüdiger, Exner, Yvonne, Hertl, Michael, Kurrle, Nina, Tikkanen, Ritva, Völlner, Frauke   +7 more
core   +1 more source

Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]

, 2002
The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Dvorankova, Barbora, Gabius, Hans-Joachim, Hercogová, Jana, Holíkova, Zuzana, Kaltner, Herbert, Motlik, Jan, Plzák, Jan, Smetana, Karel   +7 more
core   +1 more source

Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin

Frontiers in Immunology, 2022
Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt, Julia Pircher, Letyfee Steinert, Katharina Meier, Kamran Ghoreschi, Franziska Vielmuth, Daniela Kugelmann, Jens Waschke   +7 more
doaj   +1 more source

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. [PDF]

, 2016
Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood.
Johnson, Keith R., Kowalczyk, Andrew P., Lewis, Joshua D., Mahoney, My G., Overmiller, Andrew M., Roberts, Brett J., Svoboda, Robert A., Wahl, James K.   +7 more
core   +2 more sources

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

Advanced Biomedical Research, 2016
Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis.
Fariba Iraji, Nabet Tajmirriahi, Iman Momeni, Kioumars Jamshidi, Fazlollah Hashemzehi, Amir Hossein Siadat, Alireza Asemi Esfahani   +6 more
doaj   +1 more source