Results 21 to 30 of about 7,533 (183)

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed.
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Vigh, Balázs, Spindler, Volker, Waschke, Jens   +5 more
openaire   +5 more sources

Evaluation of Desmoglein 1 and Desmoglein 3 Autoantibodies in Oral Cancer: A Pilot Study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis. The alterations in the role of desmosomal components due to autoantibodies to desmoglein 1 (DSG 1)
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Raghurama Rao Gandikota, Y Sandhya Pavankumar, Divya Uppala   +4 more
openaire   +2 more sources

Anti-Desmocollin Autoantibodies in Autoimmune Blistering Diseases

Frontiers in Immunology, 2021
The presence of anti-desmocollin (Dsc) antibodies is rarely described in autoimmune blistering diseases patients. Moreover, several clinical phenotypes of pemphigus may be associated with these antibodies.
Xavier Bosch-Amate, Pilar Iranzo, Marta Ivars, José Manuel Mascaró Galy, Agustín España   +4 more
doaj   +1 more source

Desmoglein-1, differentiation, and disease [PDF]

Journal of Clinical Investigation, 2013
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
Christoph M, Hammers, John R, Stanley
openaire   +2 more sources

Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor

Dermatology Research and Practice, 2012
Modulation of cell : cell junctions is a key event in cutaneous wound repair. In this study we report that activation of the epidermal growth factor (EGF) receptor disrupts cel : cell adhesion, but with different kinetics and fates for the desmosomal ...
Miquella G. Chavez, Christian A. Buhr, Whitney K. Petrie, Angela Wandinger-Ness, Donna F. Kusewitt, Laurie G. Hudson   +5 more
doaj   +1 more source

Experience of rituximab therapy in pemphigus: A three-year retrospective study from a Sub-Himalayan State

Indian Journal of Dermatology, 2022
Background: Pemphigus is a group of auto-immune blistering disorders, characterised clinically by mucocutaneous blisters and erosions and histopathologically by intra-epidermal acantholysis.
Ghanshyam Verma, Aditi Sharma, Renu Rattan, Ajeet Negi, Mudita Gupta, Rajni Sharma   +5 more
doaj   +1 more source

Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]

Egyptian Journal of Medical Research, 2022
There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie, Laila Rashed, Mona Abdellatif, Asmaa Mohamed   +3 more
doaj   +1 more source

Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs

Anatolian Journal of Cardiology, 2023
Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang, Liang Xiaoyan, Shuai Shang, Yongqiang Fan, Huasheng Lv, Baopeng Tang, Yanmei Lu   +6 more
doaj   +1 more source

Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus. To validate this hypothesis genetically, we used desmoglein-3 knockout mice (DSG3-/-) that lose their telogen hair ...
Hanakawa, Yasushi, Matsuyoshi, Norihisa, Stanley, John R.   +2 more
openaire   +2 more sources

Cortical tension regulates desmosomal morphogenesis

Frontiers in Cell and Developmental Biology, 2022
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch, Jana Schieren, Rudolf E. Leube   +2 more
doaj   +1 more source