Results 1 to 10 of about 7,257 (168)

Desmoglein 3: A Help or a Hindrance in Cancer Progression? [PDF]

Cancers, 2015
Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity.
Hong Wan
exaly   +6 more sources

Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice. [PDF]

PLoS ONE, 2021
BackgroundPemphigus vulgaris (PV) is a rare autoimmune blistering disease characterized by the development of autoantibodies targeting desmoglein (Dsg) 3, but also against Dsg1 in mucocutaneous disease.
Katharina Boch, Sören Dräger, Detlef Zillikens, Christoph Hudemann, Christoph M Hammers, Sabrina Patzelt, Enno Schmidt, Ewan A Langan, Rüdiger Eming, Ralf J Ludwig, Katja Bieber   +10 more
doaj   +3 more sources

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Eva Hartlieb, Bettina Kempf, Miriam Partilla, Balázs Vigh, Volker Spindler, Jens Waschke   +5 more
doaj   +6 more sources

Evaluation of desmoglein 1 and desmoglein 3 autoantibodies in oral cancer: A pilot study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis.
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Raghurama Rao Gandikota, Y Sandhya Pavankumar, Divya Uppala   +4 more
doaj   +2 more sources

Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? [PDF]

Cells, 2022
Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
Anna Zakrzewicz, Celina Würth, Benedikt Beckert, Simon Feldhoff, Katrien Vanderheyden, Stian Foss, Jan Terje Andersen, Hans de Haard, Peter Verheesen, Vladimir Bobkov, Ritva Tikkanen   +10 more
doaj   +2 more sources

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Koji Sayama, Kenshi Yamasaki, Mikiko Tohyama   +2 more
exaly   +3 more sources

Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]

BMC Oral Health
Background Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood, Yasmine Ahmed Fouad, Nashwa El-Khazragy, Ahmed Elsayed Hamed Amr   +3 more
doaj   +2 more sources

Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. [PDF]

PLoS ONE, 2012
The contribution of adherens junction inactivation, typically by downregulation or mutation of the transmembrane core component E-cadherin, to cancer progression is well recognized.
Sylvain Baron, Anabel Hoang, Hannes Vogel, Laura D Attardi   +3 more
doaj   +4 more sources

Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus [PDF]

Anais Brasileiros de Dermatologia
Background Anti-desmoglein (Dsg)1 is produced in pemphigus foliaceus (PF), affecting exclusively the skin. Pemphigus vulgaris (PV) shows the production of anti-Dsg3 in the mucosal form, and anti-Dsg1 and 3 in the mucocutaneous form.
Sebastian Vernal, Tamiris Amanda Julio, Fernando Henrique Alves, Aline Turatti, Eduardo Antonio Donadi, Ana Maria Roselino   +5 more
doaj   +2 more sources

Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes [PDF]

Frontiers in Immunology
The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz, Katrien Vanderheyden, Yad Galaly, Simon Feldhoff, Magdalena Sips, Maximilian Brinkhaus, Ritva Tikkanen   +6 more
doaj   +2 more sources