Results 1 to 10 of about 6,974 (131)

Desmoglein 3: A Help or a Hindrance in Cancer Progression? [PDF]

Cancers, 2015
Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity.
Hong Wan
exaly   +6 more sources

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Yasushi Hanakawa, Yuji Shirakata, Yoko Yahata   +2 more
exaly   +3 more sources

A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3 [PDF]

Journal of Investigative Dermatology, 2002
In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1. In pemphigus foliaceus, and its endemic form, fogo selvagem by contrast, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease
Mong-Shang Lin
exaly   +3 more sources

Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. [PDF]

JCI Insight, 2017
Pemphigus vulgaris (PV) is an epithelial blistering disease caused by autoantibodies to the desmosomal cadherin desmoglein 3 (DSG3). Glucocorticoids improve disease within days by increasing DSG3 gene transcription, although the mechanism for this observation remains unknown. Here, we show that DSG3 transcription in keratinocytes is regulated by Stat3.
Mao X, Cho MJT, Ellebrecht CT, Mukherjee EM, Payne AS.   +4 more
europepmc   +4 more sources

Desmoglein 3 – Influence on oral carcinoma cell migration and invasion

Experimental Cell Research, 2018
Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but its role in carcinoma cell migration and invasion is mostly unknown. Our aim was to quantitatively analyse the motion of Dsg3-modified carcinoma cells in 2D settings and in 3D within tumour microenvironment mimicking (TMEM) matrices.
Ehsanul Hoque Apu, Saad Ullah Akram, Hong Wan   +2 more
exaly   +6 more sources

Pathogenic monoclonal antibody against desmoglein 3 augments desmoglein 3 and p38 MAPK phosphorylation in human squamous carcinoma cell line

Autoimmunity, 2006
Pemphigus vulgaris is an autoimmune blistering disease characterized by cell-cell detachment of epidermal cells. Autoantibody against desmoglein (Dsg) 3, a transmembrane glycoprotein that mediates the association of desmosomes, plays a major role in blistering in pemphigus vulgaris (PV). The mechanisms of autoantibody-induced acantholysis have not been
Yuki Kawasaki, Kazuyuki Tsunoda, Masayuki Amagai   +2 more
exaly   +3 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Evaluation of Desmoglein 1 and Desmoglein 3 Autoantibodies in Oral Cancer: A Pilot Study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis. The alterations in the role of desmosomal components due to autoantibodies to desmoglein 1 (DSG 1) and desmoglein
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Raghurama Rao Gandikota, Y Sandhya Pavankumar, Divya Uppala   +4 more
openaire   +2 more sources

Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]

Archives of Dermatology, 1999
To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
K, Ishii, M, Amagai, A, Komai, T, Ebihara, T P, Chorzelski, S, Jablonska, K, Ohya, T, Nishikawa, T, Hashimoto   +8 more
openaire   +2 more sources

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed.
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Vigh, Balázs, Spindler, Volker, Waschke, Jens   +5 more
openaire   +5 more sources