Journal of Indian Academy of Oral Medicine and RadiologyBackground: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi +4 more
doaj +2 more sources
T Lymphocytes from a Subset of Patients with Pemphigus Vulgaris Respond to Both Desmoglein-3 and Desmoglein-1 [PDF]
Journal of Investigative Dermatology, 1997 Pemphigus vulgaris and pemphigus foliaceus are cutaneous autoimmune diseases characterized by intraepithelial blisters and autoantibodies to desmosomal glycoproteins. The antigens recognized by pemphigus vulgaris and pemphigus foliaceus autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.
Lin, Mong-Shang +5 more
openaire +3 more sources
Acantholysis may precede elevation of circulating anti‐desmoglein 3 antibody levels in pemphigus vulgaris presenting with desquamative gingivitis [PDF]
Clinical and Experimental Dental Research, 2019 Pemphigus vulgaris (PV) is an autoimmune, blistering disease that affects the mucosa and skin. The current theory favors the concept that anti‐desmoglein (Dsg) 3 autoimmunity is the only pathogenic event needed to induce acantholysis.
Hiroyasu Endo +8 more
doaj +2 more sources
Autoimmunity, 2006 Pemphigus vulgaris is an autoimmune blistering disease characterized by cell-cell detachment of epidermal cells. Autoantibody against desmoglein (Dsg) 3, a transmembrane glycoprotein that mediates the association of desmosomes, plays a major role in blistering in pemphigus vulgaris (PV). The mechanisms of autoantibody-induced acantholysis have not been
Masayuki Amagai, Kazuyuki Tsunoda
exaly +3 more sources
Desmoglein ELISA in the Diagnosis of Pemphigus and Its Correlation with the Severity of Pemphigus Vulgaris [PDF]
Iranian Journal of Allergy, Asthma and Immunology, 2009 Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigus diseases. Our objective was to assess the value of ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris.
Mortazavi Hossein +8 more
doaj +1 more source
Non-COVID-19 Vaccinations and the Induction of Autoantibodies in Pemphigus Diseases: A Review of the Speculative Issue and Our Clinical-Laboratory Experience [PDF]
AntibodiesBackground: Pemphigus diseases are rare autoimmune blistering disorders mediated by pathogenic autoantibodies directed mainly against desmoglein 1 and desmoglein 3.
Maksymilian Markwitz +4 more
doaj +2 more sources
Contemporary Oncology, 2016 Aim of the study : Despite advances in surgical and radiotherapy techniques, the presence of lymph node metastasis drastically decreases the survival rate of patients with primary oral squamous cell carcinoma (OSCC).
Shruti Nagvekar +2 more
doaj +2 more sources
Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]
Egyptian Journal of Medical Research, 2022 There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie +3 more
doaj +1 more source
Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. [PDF]
Theranostics, 2021 journal ...
Lin ZC +5 more
europepmc +2 more sources
Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]
Archives of Dermatology, 1999 To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
K, Ishii +8 more
openaire +2 more sources