Results 31 to 40 of about 7,257 (168)

Suppression of the Immune Response Against Exogenous Desmoglein 3 in Desmoglein 3 Knockout Mice: An Implication for Gene Therapy [PDF]

Journal of Investigative Dermatology, 2003
Gene therapies for recessive genetic diseases may provoke unwanted immune responses against the introduced gene product because patients, especially those with null mutation of a certain protein, have no tolerance for the protein of interest. This study used desmoglein 3 knockout (Dsg3-/-) mice as a disease model for a genetic defect in DSG3, to ...
Ohyama, Manabu, Ota, Takayuki, Aoki, Miyo, Tsunoda, Kazuyuki, Harada, Reiko, Koyasu, Shigeo, Nishikawa, Takeji, Amagai, Masayuki   +7 more
openaire   +2 more sources

Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up

Clinical and Developmental Immunology, 2009
The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni-Fortina, Diana Faggion, Barbara Pigozzi, Andrea Peserico, Matteo Bordignon, Vincenzo Baldo, Mauro Alaibac   +6 more
doaj   +1 more source

Rituximab in pemphigus foliaceous with autoantibodies against both Desmoglein 1 and Desmoglein 3 [PDF]

European Journal of Dermatology, 2011
ejd.2011.1288 Auteur(s) : Rodrigo CARVALHO1 rodrigoaraujocarvalho@gmail.com, Paula MAIO1, Daniela CUNHA1, Isabel FREITAS1, Ana AFONSO2, Jorge CARDOSO1 1 Department of Dermatology and Venereology, Curry Cabral Hospital, Lisbon, Portugal 2 Department of Pathology, Curry Cabral Hospital, Lisbon, Portugal Reprints.: R. CARVALHO Pemphigus foliaceous (PF) is
Rodrigo CARVALHO, Paula MAIO, Daniela CUNHA, Isabel FREITAS, Ana AFONSO, Jorge CARDOSO   +5 more
openaire   +1 more source

Case report: Documentation of cutaneous only pemphigus vulgaris without history of mucosal lesions in North America

Frontiers in Immunology, 2022
BackgroundPemphigus is a group of autoimmune blistering diseases including Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF). These conditions exhibit lesions with mucosal or mucocutaneous (PV) or cutaneous (PF) morphology, as framed by the Desmoglein
John Baker, Kristina Seiffert-Sinha, Animesh A. Sinha   +2 more
doaj   +1 more source

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

Asian Pacific Journal of Cancer Prevention, 2014
Desmogleins (DSGs) are major members among the desmosomal cadherins critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. Reports exploring links of DSG family member expression with cancers are few and vary.
Wang-Kai, Fang, Wei, Gu, Lian-Di, Liao, Bo, Chen, Zhi-Yong, Wu, Jian-Yi, Wu, Jian, Shen, Li-Yan, Xu, En-Min, Li   +8 more
openaire   +3 more sources

Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent

Frontiers in Medicine, 2018
Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris.
Pawel Pietkiewicz, Pawel Pietkiewicz, Monika Bowszyc-Dmochowska, Justyna Gornowicz-Porowska, Marian Dmochowski   +4 more
doaj   +1 more source

Is transition between subtypes of pemphigus possible? A series of pemphigus vulgaris patients showing the transition to pemphigus foliaceus

Anais Brasileiros de Dermatologia, 2023
Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are subtypes of pemphigus with distinct clinical and laboratory features. The transition between these two subtypes has rarely been reported previously.
Rifkiye Kucukoglu, Tugba Atci, Gizem Pinar Sun   +2 more
doaj   +1 more source

The many faces of Aire in central tolerance

Frontiers in Immunology, 2013
Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
doaj   +1 more source

The Diversity of Serum Anti-DSG3 IgG Subclasses Has a Major Impact on Pemphigus Activity and Is Predictive of Relapses After Treatment With Rituximab

Frontiers in Immunology, 2022
IntroductionWe studied the distribution and in vitro pathogenicity of anti-DSG3 IgG subclasses during the course of pemphigus vulgaris (PV).MethodsWe longitudinally studied the distribution of anti-DSG3 IgG subclasses (before versus after treatment) in ...
Marie-Laure Golinski, Alexandre Lemieux, Maud Maho-Vaillant, Marion Barray, Laurent Drouot, Damien Schapman, Marie Petit, Michael Hertl, Olivier Boyer, Sébastien Calbo, Pascal Joly, Vivien Hébert   +11 more
doaj   +1 more source

Successful Treatment of Severe Adult Linear IgA Dermatosis Using Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Linear IgA dermatosis (LAD) is a rare autoimmune subepidermal bullous dermatosis, characterised by the presence of erythematous vesiculobullous lesions arranged in rosettes or herpetiform clusters. The standard treatment involves the administration of dapsone, followed by sulfasalazine, and general corticosteroid therapy, often in combination ...
Célia Delesalle, Claire Abasq‐Thomas, Claire Bocciarelli, Amélie Bourhis, Marina Alexandre, Belen Eguia, Laurent Misery, Numa Deydier   +7 more
wiley   +1 more source