Results 11 to 20 of about 7,257 (168)
Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling [PDF]
Animal Cells and Systems, 2021 Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula +3 more
doaj +2 more sources
A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3 [PDF]
Journal of Investigative Dermatology, 2002 In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1. In pemphigus foliaceus, and its endemic form, fogo selvagem by contrast, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease
Mong-Shang Lin
exaly +3 more sources
Indian Journal of Dermatology, 2016 Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area.
Asuka Yoshifuku +7 more
doaj +3 more sources
Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. [PDF]
JCI Insight, 2017 Pemphigus vulgaris (PV) is an epithelial blistering disease caused by autoantibodies to the desmosomal cadherin desmoglein 3 (DSG3). Glucocorticoids improve disease within days by increasing DSG3 gene transcription, although the mechanism for this observation remains unknown. Here, we show that DSG3 transcription in keratinocytes is regulated by Stat3.
Mao X +4 more
europepmc +4 more sources
Journal of Indian Academy of Oral Medicine and RadiologyBackground: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi +4 more
doaj +2 more sources
Acantholysis may precede elevation of circulating anti‐desmoglein 3 antibody levels in pemphigus vulgaris presenting with desquamative gingivitis [PDF]
Clinical and Experimental Dental Research, 2019 Pemphigus vulgaris (PV) is an autoimmune, blistering disease that affects the mucosa and skin. The current theory favors the concept that anti‐desmoglein (Dsg) 3 autoimmunity is the only pathogenic event needed to induce acantholysis.
Hiroyasu Endo +8 more
doaj +2 more sources
Autoimmunity, 2006 Pemphigus vulgaris is an autoimmune blistering disease characterized by cell-cell detachment of epidermal cells. Autoantibody against desmoglein (Dsg) 3, a transmembrane glycoprotein that mediates the association of desmosomes, plays a major role in blistering in pemphigus vulgaris (PV). The mechanisms of autoantibody-induced acantholysis have not been
Masayuki Amagai, Kazuyuki Tsunoda
exaly +3 more sources
Non-COVID-19 Vaccinations and the Induction of Autoantibodies in Pemphigus Diseases: A Review of the Speculative Issue and Our Clinical-Laboratory Experience [PDF]
AntibodiesBackground: Pemphigus diseases are rare autoimmune blistering disorders mediated by pathogenic autoantibodies directed mainly against desmoglein 1 and desmoglein 3.
Maksymilian Markwitz +4 more
doaj +2 more sources
Desmoglein autoantibodies and disease severity in pemphigus patients – correlations and discrepancies [PDF]
Folia Medica, 2023 Aim: To assess the correlation between the levels of anti-desmoglein-1 and anti-desmoglein-3 autoantibodies and disease severity in pemphigus patients.
Zhaneta H. Zhelyazkova +4 more
doaj +3 more sources
Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]
Egyptian Journal of Medical Research, 2022 There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie +3 more
doaj +1 more source