Frontiers in Cellular and Infection Microbiology, 2018 Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases.
Masaya Yamaguchi +2 more
exaly +4 more sources
A case of cicatricial alopecia associated with pemphigus: a case report [PDF]
Dermatology Reports, 2023 Pemphigus is a chronic autoimmune bullous disease, associated with the production of autoantibodies directed against desmosomal proteins, such as desmogleins 1 and 3 (DSG1 and DSG3).
Roberto D'Astolto +2 more
doaj +5 more sources
Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and in silico study involving HLA-DRB104:02 and 14:01 [PDF]
Frontiers in ImmunologyIntroductionPemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease characterized by autoantibodies directed against the desmosomal cadherins desmoglein 3 (DSG3) and desmoglein 1 (DSG1), which are essential for ...
Bayram Toraman +4 more
doaj +2 more sources
Characterization of desmoglein expression in the normal prostatic gland. Desmoglein 2 is an independent prognostic factor for aggressive prostate cancer. [PDF]
PLoS ONE, 2014 The expression of desmogleins (DSGs), which are known to be crucial for establishing and maintaining the cell-cell adhesion required for tissue integrity, has been well characterized in the epidermis and hair follicle; however, their expression in other ...
Alison G Barber +5 more
doaj +3 more sources
Circulating Antibodies Against DSG1 and DSG3 in Patients with Oral Lichen Planus: A Scoping Review [PDF]
AntibodiesOral Lichen Planus (OLP) is a chronic autoimmune disease with potential overlap with Pemphigus Vulgaris (PV), particularly in erosive forms. Desmoglein 1 and 3 are transmembrane glycoproteins of desmosomes, typically involved in PV.
Domenico De Falco +5 more
doaj +2 more sources
The desmosomal cadherin Desmoglein-2 controls extracellular matrix expression and remodeling via NF-κB signaling in keratinocytes [PDF]
Frontiers in Cell and Developmental BiologyDesmogleins are transmembrane cadherin proteins and obligate members of the desmosome, a cell-cell adhesion complex which connects adjacent cells and provides structural integrity to tissues.
Sadie E. Hunter +5 more
doaj +2 more sources
Scalp Involvement In Pemphigus: A Retrospective Cohort Study Of Clinical And Immunopathologic Features [PDF]
Dermatology Practical & ConceptualIntroduction: Pemphigus is a rare autoimmune blistering disease characterized by the presence of autoantibodies against desmogleins, leading to skin and mucosal blisters and erosions. Scalp involvement is common but poorly characterized.
Andrea Michelerio +6 more
doaj +2 more sources
Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]
BMC Oral HealthBackground Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood +3 more
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Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient [PDF]
Anais Brasileiros De Dermatologia, 2017 : Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3).
Jinhua Huang +2 more
exaly +3 more sources
Severe Multi-Resistant Pemphigus vulgaris: prolonged remission with a single cycle of Rituximab [PDF]
Anais Brasileiros de Dermatologia, 2013 Pemphigus vulgaris is an autoimmune bullous disease whose therapy is based on systemic corticosteroids, with or without immunosuppressants. Rituximab is a chimeric monoclonal antibody of the IgG class, directed at a specific CD20 B cell surface antigen ...
Isabela Soubhia Corral +5 more
doaj +1 more source