Results 21 to 30 of about 104 (87)

Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling

Animal Cells and Systems, 2021
Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula, Yating Su, Dilixiati Tuniyazi, Chao Yi   +3 more
doaj   +1 more source

Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4

Frontiers in Immunology, 2021
Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact
Tamara Moreno-Sosa, María Belén Sánchez, Elisa Olivia Pietrobon, Elisa Olivia Pietrobon, Juan Manuel Fernandez-Muñoz, Felipe Carlos Martín Zoppino, Flavia Judith Neira, María José Germanó, Diego Esteban Cargnelutti, Alicia Carolina Innocenti, Graciela Alma Jahn, Susana Ruth Valdez, Susana Ruth Valdez, Juan Pablo Mackern-Oberti, Juan Pablo Mackern-Oberti   +14 more
doaj   +1 more source

Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment

Journal of Indian Academy of Oral Medicine and Radiology, 2011
Pemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis with a high mortality rate if untreated. It is characterized by the binding of IgG autoantibodies to desmogleins 3 (DSG 3), a transmembrane glycoprotein adhesion molecule present on ...
G Vivekanandh Reddy, G Ramlal, K Jitendar Reddy, K Swetha, A Madhavi   +4 more
doaj   +1 more source

Keratinocyte and Fibroblast Wound Healing In Vitro Is Repressed by Non-Optimal Conditions but the Reparative Potential Can Be Improved by Water-Filtered Infrared A

Biomedicines, 2021
It is a general goal to improve wound healing, especially of chronic wounds. As light therapy has gained increasing attention, the positive influence on healing progression of water-filtered infrared A (wIRA), a special form of thermal radiation, has ...
Cornelia Wiegand, Uta-Christina Hipler, Peter Elsner, Jörg Tittelbach   +3 more
doaj   +1 more source

Successful Treatment of Severe Adult Linear IgA Dermatosis Using Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Linear IgA dermatosis (LAD) is a rare autoimmune subepidermal bullous dermatosis, characterised by the presence of erythematous vesiculobullous lesions arranged in rosettes or herpetiform clusters. The standard treatment involves the administration of dapsone, followed by sulfasalazine, and general corticosteroid therapy, often in combination ...
Célia Delesalle, Claire Abasq‐Thomas, Claire Bocciarelli, Amélie Bourhis, Marina Alexandre, Belen Eguia, Laurent Misery, Numa Deydier   +7 more
wiley   +1 more source

The desmosomal cadherin Desmoglein-2 controls extracellular matrix expression and remodeling via NF-κB signaling in keratinocytes

Frontiers in Cell and Developmental Biology
Desmogleins are transmembrane cadherin proteins and obligate members of the desmosome, a cell-cell adhesion complex which connects adjacent cells and provides structural integrity to tissues.
Sadie E. Hunter, Zara T. Patel, Beatriz Mateo, Joshua M. Powers, Austin Y. Shull, Adi D. Dubash   +5 more
doaj   +1 more source

Exploring the Nature of Desmosomal Cadherin Associations in 3D

Dermatology Research and Practice, 2010
Desmosomes are a complex assembly of protein molecules that mediate adhesion between adjacent cells. Desmosome composition is well established and spatial relationships between components have been identified.
Gethin R. Owen, David L. Stokes
doaj   +1 more source

Pemphigus vulgaris and focal segmental glomerulosclerosis (FSGS): First reported case and a review of the literature

Clinical Case Reports, 2023
Key Clinical Message There may be a connection between pemphigus vulgaris and nephrotic syndrome, as evidenced by the occurrence of focal segmental glomerulosclerosis in our pemphigus vulgaris patient and reviewing relevant literature.
Afsaneh Sadeghzadeh‐Bazargan, Atefeh Amouzegar, Maryam Abolhasani, Abbas Dehghani, Azadeh Goodarzi, Seyyedeh Tahereh Rahimi   +5 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Clinical and Immunological Study of 30 Cases With Both IgG and IgA Anti-Keratinocyte Cell Surface Autoantibodies Toward the Definition of Intercellular IgG/IgA Dermatosis

Frontiers in Immunology, 2018
Several sporadic cases, in which direct and indirect immunofluorescence studies simultaneously detected IgG and IgA autoantibodies to keratinocyte cell surfaces, have been reported mainly under the name of IgG/IgA pemphigus.
Takashi Hashimoto, Takashi Hashimoto, Kwesi Teye, Koji Hashimoto, Katarzyna Wozniak, Daisuke Ueo, Sakuhei Fujiwara, Kazuhiro Inafuku, Yorihisa Kotobuki, Ines Lakos Jukic, Branka Marinović, Anna Bruckner, Daisuke Tsuruta, Tamihiro Kawakami, Norito Ishii   +14 more
doaj   +1 more source