Results 21 to 30 of about 1,813 (210)

A REVIEW ON DESMOGLEINS, DESMOCOLLINS AND ASSOCIATED DISEASES [PDF]

, 2017
In most epithelia, desmosomes are important adhesion structures which have a key role in linking the intermediate filament network of one cell to its neighbor, thus forming a strong bond.
Muhammad Javed Khan*, Imran Khan, Irshad Ali, Sheikh Ahmed, Ghulam Mustafa Khan
core   +1 more source

Keratinocyte Binding Assay Identifies Anti-Desmosomal Pemphigus Antibodies Where Other Tests Are Negative

Frontiers in Immunology, 2018
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
Federica Giurdanella, Albertine M. Nijenhuis, Gilles F. H. Diercks, Marcel F. Jonkman, Hendri H. Pas   +4 more
doaj   +1 more source

Pemphigus vulgaris [PDF]

Anais Brasileiros de Dermatologia, 2019
: Pemphigus vulgaris is a chronic autoimmune bullous dermatosis that results from the production of autoantibodies against desmogleins 1 and 3. It is the most frequent and most severe form of pemphigus, occurring universally, usually between 40 and 60 ...
Adriana Maria Porro, Camila Arai Seque, Maria Carolina Corsi Ferreira, Milvia Maria Simões e Silva Enokihara   +3 more
doaj   +1 more source

Serologic Biomarkers in Pemphigus Monitoring: C-reactive Protein, Macrophage Migration Inhibitory Factor, and Prolactin Levels Versus Autoantibody Assays

Iranian Journal of Allergy, Asthma and Immunology, 2023
Evaluation and monitoring of pemphigus vulgaris (PV) typically involve autoantibody detection by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF).
Hossein Mortazavi, Vahide Saeidi, Kamran Balighi, Nafiseh Esmaeili, Amir Teimourpour, Maryam Daneshpazhooh, Shahin Hamzelou, Zahra Saffarian, Jafar Taghizadeh Fazli   +8 more
doaj   +1 more source

Plakoglobin Binding by Human Dsg3 (Pemphigus Vulgaris Antigen) in Keratinocytes Requires the Cadherin-Like Intracytoplasmic Segment [PDF]

, 1995
Desmogleins are transmembrane destnosonial cadherins. Two desmogleins, Dsg3 and Dsg1, have been shown to bind plakoglobin, an intracytoplasmic (IC) desmosomal plaque protein. This binding may be critical for desmosome assembly or stability. The IC domain
Roh, Joo-Young, Stanley, John R
core   +1 more source

Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus [PDF]

, 2004
Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients’ sera.
Sallie M. Neill, Hughes, GJ, Ien Chan, Andrew P. South, Black, Martin M., Oyama, N, McGrath, John A., McGrath, J A, Kawakami, Y, Fenella Wojnarowska, John A. McGrath, Mepani, K, Balbir S. Bhogal, South, AP, South, A P, Chan, Ien, Kaneko, F, Kawakami, Yoshio, Chan, I, Kirti Mepani, South, Andrew P., Bhogal, BS, Neill, Sallie M., Oyama, Noritaka, Bhogal, B S, Noritaka Oyama, Bhogal, Balbir S., David D’Cruz, Neill, SM, Mepani, Kirti, McGrath, JA, Fumio Kaneko, Kaneko, Fumio, D'Cruz, David, Hughes, G J, D'Cruz, D, Martin M. Black, Graham J. Hughes, Neill, S M, Hughes, Graham J., Yoshio Kawakami, Wojnarowska, F, Black, MM, Black, M M, Wojnarowska, Fenella   +44 more
core   +1 more source

Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?

Cells, 2022
Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
Anna Zakrzewicz, Celina Würth, Benedikt Beckert, Simon Feldhoff, Katrien Vanderheyden, Stian Foss, Jan Terje Andersen, Hans de Haard, Peter Verheesen, Vladimir Bobkov, Ritva Tikkanen   +10 more
doaj   +1 more source

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed.
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Vigh, Balázs, Spindler, Volker, Waschke, Jens   +5 more
openaire   +5 more sources

Structure of Desmosomes [PDF]

, 2022
Desmosomes are cell-cell junctions that connect neighboring cells to their intermediate filament networks that serve to provide mechanical strength to the tissue.
Ena Sokol, Sokol, Ena
core   +1 more source

Evaluation of Desmoglein 1 and Desmoglein 3 Autoantibodies in Oral Cancer: A Pilot Study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis. The alterations in the role of desmosomal components due to autoantibodies to desmoglein 1 (DSG 1)
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Raghurama Rao Gandikota, Y Sandhya Pavankumar, Divya Uppala   +4 more
openaire   +2 more sources