Results 11 to 20 of about 1,813 (210)
Identification of Desmogleins as Disease Targets [PDF]
Journal of Investigative Dermatology, 2007 While it had long been known that desmosomes were crucial for interconnecting cells in laboratory experiments, the link between desmosomal adhesion and human health was bolstered by several key experiments demonstrating that desmogleins were targeted in both autoimmune and infectious diseases.
Simpson, Cory L., Green, Kathleen J.
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Desmogleins and Desmocollins as Adhesive Molecules [PDF]
Journal of Investigative Dermatology, 2007 Following the identification of desmoglein and desmocollins as the transmembrane components of the desmosome, sequence analysis re vealed that they are members of the cadherin family of cell–cell adhesion molecules. Cadherins are characterized by the presence of conserved extracellular calcium-binding motifs.
Wahl, James K., James K. Wahl
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Desmoglein as a Target in Skin Disease and Beyond [PDF]
Journal of Investigative Dermatology, 2012 Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes ...
Amagai, Masayuki, Stanley, John R.
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Autoantibodies other than anti-desmogleins in pemphigus vulgaris patients
Indian Journal of Dermatology, 2017 Background: Pemphigus vulgaris (PV) is an immunoglobulin G-mediated autoimmune bullous skin disease. Nonorgan-specific antibodies were detected in Tunisian and Brazilian pemphigus patients with different prevalence.
Marwah Adly Saleh +2 more
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Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer [PDF]
BMC Cancer, 2008 Background In a previous report we have demonstrated that the chymotryptic-like serine protease kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic cancer.
Haun Randy S +2 more
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Exploring the Nature of Desmosomal Cadherin Associations in 3D [PDF]
Dermatology Research and Practice, 2010 Desmosomes are a complex assembly of protein molecules that mediate adhesion between adjacent cells. Desmosome composition is well established and spatial relationships between components have been identified.
Gethin R. Owen, David L. Stokes
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Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]
Archives of Dermatology, 1999 To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
K, Ishii +8 more
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Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]
Journal of Investigative Dermatology, 2002 The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Hanakawa, Yasushi +8 more
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Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Pemphigus‐associated cardiomyopathy: report of autoimmune myocarditis and review of literature
ESC Heart Failure, 2021 Pemphigus is a rare disease characterized by bullous lesions of the skin and mucous membranes. The aetiology is autoimmune and related to the formation of IgG autoantibodies against desmogleins, which are structural proteins of desmosomes that ensure the
Andrea Frustaci +9 more
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