Results 41 to 50 of about 1,813 (210)

Desmogleins: Hair perspective

International Journal of Trichology, 2013
Desmogleins (Dsgs) are calcium-dependent, transmembrane glycoproteins belonging to the desmosomal cadherin superfamily, which play significant roles in selective calcium ions (Ca(2+)) dependent adhesion interactions between cell surfaces. Four subtypes of Dsg have been identified.
openaire   +3 more sources

Rare types of pemphigus vulgaris: A herpetiform subtype. Case report

Consilium Medicum
Pemphigus refers to a group of rare autoimmune disorders affecting the skin and mucous membranes, which are characterized by the formation of intraepidermal blisters resulting from acantholysis, which is the disruption of intercellular connections ...
Ekaterina V. Lebedeva, Ekaterina E. Radionova, Elena V. Denisova, Evgenii N. Malyarenko, Oksana R. Katunina, Madina D. Shakirzyanova, Irina M. Korsunskaya   +6 more
doaj   +1 more source

Identification of Desmoglein as a Cadherin and Analysis of Desmoglein Domain Structure

Journal of Investigative Dermatology, 2007
In the 1980s and early 1990s, the ability to clone complementary DNA (cDNA) resulted in great advances in cell biology, including our understanding of cell adhesion. Cloning the cDNA encoding desmosomal molecules, and the determination of their deduced amino-acid sequences, provided novel insights into their structure and function. It had been shown by
openaire   +3 more sources

Pemphigus—A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms

Frontiers in Immunology, 2018
Pemphigus is a severe autoimmune-blistering disease of the skin and mucous membranes caused by autoantibodies reducing desmosomal adhesion between epithelial cells.
Volker Spindler, Jens Waschke
doaj   +1 more source

Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling

Animal Cells and Systems, 2021
Desmogleins (DSGs), with the ability to link adjacent cells, have been shown to participate in the development of malignancy. DSG3 was up-regulated in various cancers, including lung, head and neck, and esophagus squamous cell carcinoma, which ...
Yimamumaimaitijiang Abula, Yating Su, Dilixiati Tuniyazi, Chao Yi   +3 more
doaj   +1 more source

Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4

Frontiers in Immunology, 2021
Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact
Tamara Moreno-Sosa, María Belén Sánchez, Elisa Olivia Pietrobon, Elisa Olivia Pietrobon, Juan Manuel Fernandez-Muñoz, Felipe Carlos Martín Zoppino, Flavia Judith Neira, María José Germanó, Diego Esteban Cargnelutti, Alicia Carolina Innocenti, Graciela Alma Jahn, Susana Ruth Valdez, Susana Ruth Valdez, Juan Pablo Mackern-Oberti, Juan Pablo Mackern-Oberti   +14 more
doaj   +1 more source

Diagnostic and prognostic impact of desmocollins in human lung cancer [PDF]

, 2012
Desmosomes are intercellular junctions that confer strong cell-cell adhesion. Two main members of desmosomal cadherins, desmogleins (DSGs) and desmocollins (DSCs), are involved in carcinogenesis. However, their role in human lung cancer remained elusive.
Petersen, Iver, Presselt, Norbert, Chen, Yuan, Mireskandari, Masoud, Kunze, Almut, Yang, Linlin, Zhang, Qing, Cui, Tiantian, Kohler, Lukas Herbert, Knösel, Thomas   +9 more
core   +1 more source

Atypical pemphigus: autoimmunity against desmocollins and other non-desmoglein autoantigens [PDF]

, 2020
In this review, we recap current knowledge about non-desmoglein autoantigens in atypical forms of autoimmune pemphigus. More than 50 keratinocyte proteins, including adhesion molecules, receptors and enzymes as well as mitochondrial proteins can be ...
Marzano, Angelo V, Grando, Sergei, Gualtieri, Bruno   +2 more
core   +1 more source

Significado do epitope spreading na patogênese dos pênfigos vulgar e foliáceo Significance of epitope spreading in the pathogenesis of pemphigus vulgaris and foliaceus

Anais Brasileiros de Dermatologia, 2008
Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda da coesão celular.
Valéria Aoki, Fernanda Lago, Márcia Harumi Yamazaki, Cláudia Giuli Santi, Celina Wakisaka Maruta   +4 more
doaj   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source