Results 61 to 70 of about 104 (87)

Treatment of pemphigus and other neglected skin conditions with PC111, a human anti-Fas Ligand monoclonal antibody: a potential disease modifier

Journal of Dermatological Treatment
Background Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease with high morbidity and mortality, treated mainly with long-term immunosuppressants. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is an acute, life-threatening
Roberta Lotti, Antonino Amato, Brydon Bennett, Tommaso Zanocco-Marani, Alessandra Marconi, Carlo Pincelli   +5 more
doaj   +1 more source

Desmosomes: Structure, Pathologies, and Signaling Dynamics

Korean Journal of Clinical Laboratory Science
Desmosomes are a type of cell-to-cell junction, specialized intercellular structures that maintain tissue cohesion and structural integrity under mechanical stress.
Jiyun HONG, Ki-Jong RHEE
doaj   +1 more source

Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus

JCI Insight, 2020
A possible etiological link between the onset of endemic pemphigus in Tunisia and bites of Phlebotomus papatasi, the vector of zoonotic cutaneous leishmaniasis, has been previously suggested. We hypothesized that the immunodominant P.
Soumaya Marzouki, Ines Zaraa, Maha Abdeladhim, Chaouki Benabdesselem, Fabiano Oliveira, Shaden Kamhawi, Mourad Mokni, Hechmi Louzir, Jesus G. Valenzuela, Melika Ben Ahmed   +9 more
doaj   +1 more source

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Frontiers in Immunology, 2019
Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1).
Roberta Lotti, Claudio Giacinto Atene, Alessandra Marconi, Giulia Di Rocco, L. Reggiani Bonetti, Tommaso Zanocco Marani, Carlo Pincelli   +6 more
doaj   +1 more source

Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris

Mediators of Inflammation, 2017
Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still
Rodolfo Pessato Timoteo, Marcos Vinicius da Silva, Camila Botelho Miguel, Djalma Alexandre Alves Silva, Jonatas Da Silva Catarino, Virmondes Rodrigues Junior, Helioswilton Sales-Campos, Carlo Jose Freire Oliveira   +7 more
doaj   +1 more source

Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus

Frontiers in Immunology, 2018
Pemphigus is a blistering disease characterized by pemphigus autoantibodies (PVIgG) directed mostly against desmogleins (Dsgs), resulting in the loss of keratinocyte adhesion (acantholysis).
Roberta Lotti, En Shu, Tiziana Petrachi, Alessandra Marconi, Elisabetta Palazzo, Marika Quadri, Ann Lin, Lorraine A. O’Reilly, Lorraine A. O’Reilly, Carlo Pincelli   +9 more
doaj   +1 more source

Diagnostic Utility of BIOCHIP Mosaic Indirect Immunofluorescence in Intraepidermal Autoimmune Blistering Diseases

Clinical Dermatology Review
Background: Pemphigus is a chronic intraepidermal autoimmune blistering disorder (IABD) characterized by the presence of circulating autoantibodies against desmogleins 1and 3.
Padmini Chitradurga Vijayasarathy, Rajalakshmi Tirumalae   +1 more
doaj   +1 more source

天疱疮发病机制与生物标记物的研究进展

Zhongguo shiyan zhenduanxue
天疱疮（pemphigus）是一类严重的、慢性皮肤黏膜自身免疫性大疱性疾病, 常常表现为皮肤黏膜出现水疱、糜烂，其传统的诊断标记物是抗桥粒芯糖蛋白（desmogleins，Dsg）1，3的免疫球蛋白G抗体。随着研究的不断深入，许多学者发现，天疱疮的生物标记物还有许多非桥粒芯（糖）蛋白，它们也参与了棘层的松解。本文对近年来天疱疮发病机制与生物标记物的最新研究进展做一综述，为该疾病的诊断及预防提供一定的理论依据。
许立硕, 葛翠翠, 刘晨光
doaj  

Scalp Involvement In Pemphigus: A Retrospective Cohort Study Of Clinical And Immunopathologic Features

Dermatology Practical & Conceptual
Introduction: Pemphigus is a rare autoimmune blistering disease characterized by the presence of autoantibodies against desmogleins, leading to skin and mucosal blisters and erosions. Scalp involvement is common but poorly characterized.
Andrea Michelerio, Stefania Barruscotti, Mara De Amici, Giacomo Fiandrino, Valeria Brazzelli, Carlo Tomasini, Camilla Vassallo   +6 more
doaj   +1 more source

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Expression of desmogleins 1–3 and their clinical impacts on human lung cancer

Pathology Research and Practice, 2015
Tiantian Cui, Linlin Yang
exaly