Results 81 to 90 of about 1,813 (210)
Successful Treatment of Severe Adult Linear IgA Dermatosis Using Dupilumab
JEADV Clinical Practice, Volume 5, Issue 3, Page 943-945, September 2026.ABSTRACT Linear IgA dermatosis (LAD) is a rare autoimmune subepidermal bullous dermatosis, characterised by the presence of erythematous vesiculobullous lesions arranged in rosettes or herpetiform clusters. The standard treatment involves the administration of dapsone, followed by sulfasalazine, and general corticosteroid therapy, often in combination ...
Célia Delesalle +7 more
wiley +1 more source
Desmoglein directs differentiation [PDF]
Journal of Cell Biology, 2009 The cell adhesion protein desmoglein 1 (Dsg1) has an extra function in suppressing EGF receptor (EGFR) signaling, helping skin cells differentiate into the different layers of the epidermis, report [Getsios, Simpson, et al.][1] ![Figure][2] Activated EGFR (green) is only found in the ...
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Rituximab in pemphigus foliaceous with autoantibodies against both Desmoglein 1 and Desmoglein 3 [PDF]
European Journal of Dermatology, 2011 ejd.2011.1288 Auteur(s) : Rodrigo CARVALHO1 rodrigoaraujocarvalho@gmail.com, Paula MAIO1, Daniela CUNHA1, Isabel FREITAS1, Ana AFONSO2, Jorge CARDOSO1 1 Department of Dermatology and Venereology, Curry Cabral Hospital, Lisbon, Portugal 2 Department of Pathology, Curry Cabral Hospital, Lisbon, Portugal Reprints.: R. CARVALHO Pemphigus foliaceous (PF) is
Rodrigo CARVALHO +5 more
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, 2000 The desmosomal cadherins comprise the desmocollins and desmogleins and are involved in epithelial cell-cell adhesion. There are three desmocollins (DSC 1-3) and three desmogleins (DSG 1-3) that are expressed in a tissue- and development-specific manner ...
Vogazianou, A P +8 more
core +1 more source
Genomic Sequence Analysis of the Mouse Desmoglein Cluster Reveals Evidence for Six Distinct Genes: Characterization of Mouse DSG4, DSG5, and DSG6 [PDF]
, 2003 The desmosomal cadherins, comprising the desmogleins and desmocollins, are calcium-dependent transmembrane adhesion molecules that are essential for the cell adhesive role of desmosomes. Until recently, three mouse and three human desmoglein isoforms had
Whittock, Neil Vincent
core +1 more source
MedComm, Volume 7, Issue 9, September 2026.This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu +12 more
wiley +1 more source
The expressions of desmoglein 1 and 3 according to chronologic skin aging
, 2018 Background: Desmogleins ate transmembrane glycoproteins of the desmosome which provide mechanical strength to epithelial tissue. Desmogleins have so far, been implicated in several diseases such as pemphigus, striate palmoplantar keratoderma, 4S and ...
최유원
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American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg +9 more
wiley +1 more source
Desmoglein expression in normal human prostate.
, 2014 (A) Clear expression of mRNA can be detected for most desmogleins, with the exception of DSG1 which shows only faint expression. (B–C) Representative immunofluorescence analyses of DSG2 (B) and DSG4 (C) at the cell border of normal human prostatic ...
Alison G. Barber (572664) +5 more
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Plakophilins, Desmogleins, and Pemphigus: The Tail Wagging the Dog [PDF]
, 2014 The importance of desmosomal cell adhesion to human health is evidenced by the autoimmune disease pemphigus vulgaris (PV), in which autoantibodies against the extracellular domain of the desmosomal cadherin desmoglein 3 cause potentially fatal blistering
Payne, Aimee S. +1 more
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