Results 101 to 110 of about 1,813 (210)

Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix

, 2003
We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs)
Coleman, N., Stanley, M. A., Alazawi, W. O F, Garrod, D. R., Morris, L. S.   +4 more
core   +1 more source

Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: a case report

Journal of Medical Case Reports, 2018
Background Paraneoplastic pemphigus is a rare multiorgan disease of autoimmune causes, usually triggered by neoplasias, mainly of lymphoproliferative origin, such as leukemia and lymphoma.
Richard Lucas Konichi-Dias, Aline Fernanda Ramos, Mauricio Eiji de Almeida Santos Yamashita, Cristiane Botelho Miranda Cárcano   +3 more
doaj   +1 more source

Characterization of a keratinocyte-specific extracellular epitope of desmoglein. Implications for desmoglein heterogeneity and function.

Journal of Biological Chemistry, 1992
Despite the presumed importance of desmoglein, a 160-kDa glycoprotein, in desmosome formation and its possible involvement in certain blistering skin diseases, the precise location and function of this protein have not yet been firmly established. We describe here the characterization of a new monoclonal antibody, AE23, against an extracellular epitope
C A, Loomis, J, Kolega, M, Manabe, T T, Sun   +3 more
openaire   +2 more sources

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength [PDF]

, 2002
By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaffold that imparts mechanical strength to a tissue.
Godsel, Lisa M., Hudson, TY, Green, Kathleen J., Kathleen J. Green, Gumbiner, BM, Hudson, Tracie Y., Kelsell, David P., Leigh, IM, Leigh, Irene M., Evangeline V. Amargo, Anne K. Mongiu, Huen, Arthur C., Leslie J. Bannon, Bannon, Leslie J., Mongiu, AK, David P. Kelsell, Kelsell, DP, Park, Jung K., Park, JK, Green, KJ, Huen, AC, Chen, XJ, Xuejun Chen, Bannon, LJ, Arthur C. Huen, Amargo, Evangeline V., Gumbiner, Barry M., Chen, Xuejun, Tracie Y. Hudson, Irene M. Leigh, Lisa M. Godsel, Barry M. Gumbiner, Mongiu, Anne K., Jung K. Park, Amargo, FV, Godsel, LM   +35 more
core   +1 more source

Oesophagitis dissecans superficialis: an acute, benign phenomenon associated with pemphigus vulgaris

, 2009
Pemphigus vulgaris (PV) is an autoimmune dermatosis that may evolve to severely compromise the skin and/or mucosa. Autoantibodies directed against epithelial cadherins, such as desmogleins 1 and 3, lead to acantholysis and culminate in blister formation.
BARRIOS, M. M., AOKI, V., SANTI, G. G., CESAR, W. G. G., MARUTA, C. W.   +4 more
core   +1 more source

Treatment of pemphigus and other neglected skin conditions with PC111, a human anti-Fas Ligand monoclonal antibody: a potential disease modifier

Journal of Dermatological Treatment
Background Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease with high morbidity and mortality, treated mainly with long-term immunosuppressants. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is an acute, life-threatening
Roberta Lotti, Antonino Amato, Brydon Bennett, Tommaso Zanocco-Marani, Alessandra Marconi, Carlo Pincelli   +5 more
doaj   +1 more source

Desmoglein Isotype Expression in the Hair Follicle and its Cysts Correlates with Type of Keratinization and Degree of Differentiation [PDF]

, 2003
Within stratified squamous epithelia, such as the epidermis, desmogleins are generally expressed in a differentiation-specific manner. Similar to the epidermis, the hair follicle is compartmentalized into a hierarchy of cell types based on their level of
Stanley, John R., Cotsarelis, George, Wu, Hong   +2 more
core   +1 more source

Desmosomes: Structure, Pathologies, and Signaling Dynamics

Korean Journal of Clinical Laboratory Science
Desmosomes are a type of cell-to-cell junction, specialized intercellular structures that maintain tissue cohesion and structural integrity under mechanical stress.
Jiyun HONG, Ki-Jong RHEE
doaj   +1 more source

Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus

JCI Insight, 2020
A possible etiological link between the onset of endemic pemphigus in Tunisia and bites of Phlebotomus papatasi, the vector of zoonotic cutaneous leishmaniasis, has been previously suggested. We hypothesized that the immunodominant P.
Soumaya Marzouki, Ines Zaraa, Maha Abdeladhim, Chaouki Benabdesselem, Fabiano Oliveira, Shaden Kamhawi, Mourad Mokni, Hechmi Louzir, Jesus G. Valenzuela, Melika Ben Ahmed   +9 more
doaj   +1 more source

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Frontiers in Immunology, 2019
Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1).
Roberta Lotti, Claudio Giacinto Atene, Alessandra Marconi, Giulia Di Rocco, L. Reggiani Bonetti, Tommaso Zanocco Marani, Carlo Pincelli   +6 more
doaj   +1 more source