PLoS ONE, 2014 Desmosomes are intercellular adhesive junctions of major importance for tissue integrity. To allow cell motility and migration they are down-regulated in epidermal wound healing.
David Garrod, Selina McHarg
exaly +3 more sources
Desmosomes as Signaling Hubs in the Regulation of Cell Behavior [PDF]
Frontiers in Cell and Developmental Biology, 2021 Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Mechthild Hatzfeld, René Keil
exaly +4 more sources
Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin [PDF]
Frontiers in Immunology, 2022 Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt +7 more
doaj +2 more sources
A transitional desmosome/tonofibril network may relay mechanical strain to epidermal nerve terminals with high fidelity and sensitivity in the Cuban crocodile (Crocodylus rhombifer): an ultrastructural study [PDF]
Frontiers in Cell and Developmental BiologyBackgroundCrocodilians are well endowed with multiple cutaneous receptors and specializations, such as integumentary sensory organs (ISOs), which provide formidable mechanical sensitivity despite their protected shield.
Karl-Gunnar Melkersson +5 more
doaj +2 more sources
Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity. [PDF]
MedComm (2020)This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Z +12 more
europepmc +2 more sources
CCDC120 phase separation contributes to desmosomal integrity and cardiac function [PDF]
Nature CommunicationsDesmosomes are cell-cell adhesive junctions that provide structural integrity and mechanical resistance to tissues. Disruptions in desmosome organization lead to severe cardiac and dermatological disorders.
Hui Meng +13 more
doaj +2 more sources
The impact of signaling pathways on the desmosome ultrastructure in pemphigus [PDF]
Frontiers in ImmunologyIntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Thomas Schmitt +5 more
doaj +2 more sources
Actomyosin forces trigger a conformational change in desmoplakin within desmosomes [PDF]
Nature CommunicationsDesmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong +6 more
doaj +2 more sources
Plakoglobin phosphorylation at serine 665 is capable of stabilizing cadherin-mediated adhesion in keratinocytes [PDF]
JCI InsightIn pemphigus, autoantibodies against the desmosomal cadherins desmoglein (DSG) DSG1 and DSG3 cause intraepidermal blistering. Recently, we found that increasing cAMP with the phosphodiesterase-4 inhibitor apremilast stabilizes keratinocyte cohesion in ...
Franziska Vielmuth +15 more
doaj +2 more sources
Российский кардиологический журнал, 2021 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary myocardial disease with a high risk of sudden cardiac death. The most common genetic forms of the disease are associated with desmosomal gene mutations.Aim. To study the prevalence of
A. G. Shestak +4 more
doaj +1 more source