Results 1 to 10 of about 14,857 (218)
Dermatology Research and Practice, 2010 The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength.
David Garrod
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PLoS ONE, 2014 Desmosomes are intercellular adhesive junctions of major importance for tissue integrity. To allow cell motility and migration they are down-regulated in epidermal wound healing.
David R Garrod
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Desmosomes as Signaling Hubs in the Regulation of Cell Behavior [PDF]
Frontiers in Cell and Developmental Biology, 2021 Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Mechthild Hatzfeld +2 more
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Actomyosin forces trigger a conformational change in desmoplakin within desmosomes [PDF]
Nature CommunicationsDesmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong +6 more
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Assembly of Desmosomal Cadherins into Desmosomes is Isoform Dependent [PDF]
Journal of Investigative Dermatology, 2001 Desmosomes are intercellular adhesive junctions that exhibit cell- and differentiation-specific differences in their molecular composition. In complex epithelia, desmosomes contain multiple representatives of the desmosomal cadherin family, which includes three desmogleins and three desmocollins.
Ishii, Ken +5 more
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, 2015 Desmosomes are cell-cell junctions that connect neighboring cells to their intermediate filament networks that serve to provide mechanical strength to the tissue. Major proteins that compose desmosomes are desmogleins, desmocollins, plakoglobin, plakophilins and desmoplakin.
Ena Sokol, Sokol, Ena
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Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin [PDF]
Frontiers in Immunology, 2022 Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt +7 more
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A transitional desmosome/tonofibril network may relay mechanical strain to epidermal nerve terminals with high fidelity and sensitivity in the Cuban crocodile (Crocodylus rhombifer): an ultrastructural study [PDF]
Frontiers in Cell and Developmental BiologyBackgroundCrocodilians are well endowed with multiple cutaneous receptors and specializations, such as integumentary sensory organs (ISOs), which provide formidable mechanical sensitivity despite their protected shield.
Karl-Gunnar Melkersson +5 more
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Desmosomes in Developing Human Epidermis [PDF]
Dermatology Research and Practice, 2010 Desmosomes play important roles in the cell differentiation and morphogenesis of tissues. Studies on animal models have greatly increased our knowledge on epidermal development while reports on human developing skin are rare due to the difficult ...
Sirkku Peltonen +2 more
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Histology and histopathology, 1997 Considerable progress has been made in our knowledge of desmosomes and their components. Molecular cloning of the desmosomal glycoproteins has established that desmoglein 1 and desmoglein 3 are targets for autoantibodies in the blistering diseases pemphigus foliaceus and pemphigus vulgaris respectively.
Chidgey, M.A.J.
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