Results 11 to 20 of about 15,816 (206)
Dermatology Research and Practice, 2010 The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength.
David Garrod
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, 2015 Desmosomes are cell-cell junctions that connect neighboring cells to their intermediate filament networks that serve to provide mechanical strength to the tissue. Major proteins that compose desmosomes are desmogleins, desmocollins, plakoglobin, plakophilins and desmoplakin.
Ena Sokol, Sokol, Ena
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Assembly of Desmosomal Cadherins into Desmosomes is Isoform Dependent [PDF]
Journal of Investigative Dermatology, 2001 Desmosomes are intercellular adhesive junctions that exhibit cell- and differentiation-specific differences in their molecular composition. In complex epithelia, desmosomes contain multiple representatives of the desmosomal cadherin family, which includes three desmogleins and three desmocollins.
Ishii, Ken +5 more
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Histology and histopathology, 1997 Considerable progress has been made in our knowledge of desmosomes and their components. Molecular cloning of the desmosomal glycoproteins has established that desmoglein 1 and desmoglein 3 are targets for autoantibodies in the blistering diseases pemphigus foliaceus and pemphigus vulgaris respectively.
Chidgey, M.A.J.
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Desmosomes in Developing Human Epidermis [PDF]
Dermatology Research and Practice, 2010 Desmosomes play important roles in the cell differentiation and morphogenesis of tissues. Studies on animal models have greatly increased our knowledge on epidermal development while reports on human developing skin are rare due to the difficult ...
Sirkku Peltonen +2 more
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Desmosomes and disease: an update [PDF]
, 2002 Desmosomes play a critical role in the maintenance of normal tissue architecture. Skin blistering can occur when desmosomal adhesion is compromised by antibodies in autoimmune diseases such as pemphigus.
Chidgey, Martyn
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Cold Spring Harbor Perspectives in Biology, 2009 Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit ...
Emmanuella, Delva +2 more
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Journal of Cell Science, 2009 Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Tight junctions and adherens junctions (AJs) are restricted to the apical domain, where they form the epithelial barrier and organize cortical actin, respectively.
Bhushan V, Desai +2 more
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Cells, 2023 The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 ...
Hong Wan +3 more
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Vaccines, 2022 Pemphigus vulgaris (PV) is a chronic, life-altering autoimmune disease due to the production of anti-desmoglein antibodies causing the loss of cell–cell adhesion in keratinocytes (acantholysis) and blister formation in both skin and mucous membranes. The
Morna F. Schmidt +4 more
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