Results 11 to 20 of about 14,857 (218)
The impact of signaling pathways on the desmosome ultrastructure in pemphigus [PDF]
Frontiers in ImmunologyIntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Thomas Schmitt +5 more
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Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
Nature Communications, 2018 Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J. Price +5 more
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Cold Spring Harbor Perspectives in Biology, 2009 Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit ...
Emmanuella, Delva +2 more
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Российский кардиологический журнал, 2021 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary myocardial disease with a high risk of sudden cardiac death. The most common genetic forms of the disease are associated with desmosomal gene mutations.Aim. To study the prevalence of
A. G. Shestak +4 more
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Journal of Cell Science, 2009 Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Tight junctions and adherens junctions (AJs) are restricted to the apical domain, where they form the epithelial barrier and organize cortical actin, respectively.
Bhushan V, Desai +2 more
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Cells, 2023 The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 ...
Hong Wan +3 more
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Vaccines, 2022 Pemphigus vulgaris (PV) is a chronic, life-altering autoimmune disease due to the production of anti-desmoglein antibodies causing the loss of cell–cell adhesion in keratinocytes (acantholysis) and blister formation in both skin and mucous membranes. The
Morna F. Schmidt +4 more
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Paradoxical Roles of Desmosomal Components in Head and Neck Cancer
Biomolecules, 2021 Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development.
Yin-Qiao Liu +3 more
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Cheek-Pro-Heart: What Can the Buccal Mucosa Do for Arrhythmogenic Cardiomyopathy?
Biomedicines, 2023 Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease associated with ventricular arrhythmias and a high risk of sudden cardiac death (SCD). Although the disease was described over 40 years ago, its diagnosis is still difficult.
Carlos Bueno-Beti, Angeliki Asimaki
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Biology, 2020 Tumor resistance to therapy is associated with the 3D organization and peculiarities of the tumor microenvironment, of which intercellular adhesion is a key participant. In this work, the abundance of contact proteins was compared in SKOV-3 and SKOV-3.ip
Olga M. Kutova +6 more
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