Results 21 to 30 of about 15,816 (206)

Comparative Analysis of Cell–Cell Contact Abundance in Ovarian Carcinoma Cells Cultured in Two- and Three-Dimensional In Vitro Models

Biology, 2020
Tumor resistance to therapy is associated with the 3D organization and peculiarities of the tumor microenvironment, of which intercellular adhesion is a key participant. In this work, the abundance of contact proteins was compared in SKOV-3 and SKOV-3.ip
Olga M. Kutova, Ludmila M. Sencha, Anton D. Pospelov, Olga E. Dobrynina, Anna A. Brilkina, Elena I. Cherkasova, Irina V. Balalaeva   +6 more
doaj   +1 more source

Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs

Anatolian Journal of Cardiology, 2023
Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang, Liang Xiaoyan, Shuai Shang, Yongqiang Fan, Huasheng Lv, Baopeng Tang, Yanmei Lu   +6 more
doaj   +1 more source

Genetic Animal Models for Arrhythmogenic Cardiomyopathy

Frontiers in Physiology, 2020
Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes right or biventricular cardiomyopathy associated with ventricular arrhythmia.
Brenda Gerull, Brenda Gerull, Andreas Brodehl   +2 more
doaj   +1 more source

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength [PDF]

, 2002
By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaffold that imparts mechanical strength to a tissue.
Godsel, Lisa M., Hudson, TY, Green, Kathleen J., Kathleen J. Green, Gumbiner, BM, Hudson, Tracie Y., Kelsell, David P., Leigh, IM, Leigh, Irene M., Evangeline V. Amargo, Anne K. Mongiu, Huen, Arthur C., Leslie J. Bannon, Bannon, Leslie J., Mongiu, AK, David P. Kelsell, Kelsell, DP, Park, Jung K., Park, JK, Green, KJ, Huen, AC, Chen, XJ, Xuejun Chen, Bannon, LJ, Arthur C. Huen, Amargo, Evangeline V., Gumbiner, Barry M., Chen, Xuejun, Tracie Y. Hudson, Irene M. Leigh, Lisa M. Godsel, Barry M. Gumbiner, Mongiu, Anne K., Jung K. Park, Amargo, FV, Godsel, LM   +35 more
core   +1 more source

Paradoxical Roles of Desmosomal Components in Head and Neck Cancer

Biomolecules, 2021
Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development.
Yin-Qiao Liu, Hai-Ying Zou, Jian-Jun Xie, Wang-Kai Fang   +3 more
doaj   +1 more source

Pervanadate stabilizes desmosomes [PDF]

Cell Adhesion & Migration, 2008
Desmosomes are intercellular junctions responsible for strong cell-cell adhesion in epithelia and cardiac muscle. Numerous studies have shown that the other major type of epithelial cell adhesion, the adherens junction, is destabilized by src-induced tyrosine phosphorylation of two of its principal components, E-cadherin and beta-catenin.
Garrod, D., Fisher, C., Smith, A., Nie, Z.   +3 more
openaire   +3 more sources

iRHOM2 in skin disease and oesophageal cancer [PDF]

, 2015
PhDMutations in RHBDF2, the gene encoding inactive rhomboid protein iRHOM2, result in the dominantly inherited condition Tylosis with oesophageal cancer (TOC). TOC causes plamoplantar keratoderma, oral precursor lesions and up to a 95 % life-time risk of
Etheridge, Sarah
core   +4 more sources

Implications of normal and disordered remodeling dynamics of corneodesmosomes in stratum corneum

Dermatologica Sinica, 2015
Desmosomes and corneodesmosomes are the most important adhering junctions, providing strength for the epidermal sheet structure made of living keratinocytes and enucleated stratum corneum corneocytes, respectively.
Yasuo Kitajima
doaj   +1 more source

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Bettina Kempf, Partilla, Miriam, Jens Waschke, Hartlieb, Eva, Waschke, Jens, Kempf, Bettina, Eva Hartlieb (103934), Vigh, Balázs, Miriam Partilla, Miriam Partilla (103942), Balázs Vigh, Bettina Kempf (103938), Eva Hartlieb, Volker Spindler (103952), Balázs Vigh (103947), Jens Waschke (103956), Spindler, Volker, Volker Spindler   +17 more
core   +2 more sources

The Desmosomal Cadherin Desmoglein-2 Experiences Mechanical Tension as Demonstrated by a FRET-Based Tension Biosensor Expressed in Living Cells

Cells, 2018
Cell-cell junctions are critical structures in a number of tissues for mechanically coupling cells together, cell-to-cell signaling, and establishing a barrier. In many tissues, desmosomes are an important component of cell-cell junctions.
Sindora R. Baddam, Paul T. Arsenovic, Vani Narayanan, Nicole R. Duggan, Carl R. Mayer, Shaston T. Newman, Dahlia A. Abutaleb, Abhinav Mohan, Andrew P. Kowalczyk, Daniel E. Conway   +9 more
doaj   +1 more source