Results 41 to 50 of about 15,816 (206)

Role of PKC and ERK Signaling in Epidermal Blistering and Desmosome Regulation in Pemphigus

Frontiers in Immunology, 2019
Desmosomes reinforce cohesion of epithelial cells at the interface between adjacent cells. They include the cadherin-type adhesion molecules desmoglein 1 (Dsg1) and Dsg3.
Desalegn Tadesse Egu, Daniela Kugelmann, Jens Waschke   +2 more
doaj   +1 more source

Calcium-independent desmosomes of keratinocytes are hyper-adhesive [PDF]

, 2006
Desmosomes in tissues are resistant to disruption by chelation of extracellular calcium. It has been suggested that this represents a hyper-adhesive state of these intercellular junctions that is crucial for the maintenance of epidermal integrity ...
Anita J. Merritt, David R. Garrod, Tomomi E. Kimura, Garrod, David R., Kimura, Tomomi E., Merritt, Anita J.   +5 more
core   +1 more source

Pemphigus—A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms

Frontiers in Immunology, 2018
Pemphigus is a severe autoimmune-blistering disease of the skin and mucous membranes caused by autoantibodies reducing desmosomal adhesion between epithelial cells.
Volker Spindler, Jens Waschke
doaj   +1 more source

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source

Molecular force measurements in desmosomes [PDF]

, 2018
Desmosomes are cell–cell adhesion sites especially important in heart and skin tissues. Both tissues are exposed to mechanical stress and desmosomes are essential for stable cell–cell adhesion but whether and how forces act on desmosomes was unclear ...
Cost, A., Cost, Anna-Lena
core   +2 more sources

Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression

Frontiers in Physiology, 2018
Background: Mutations in plakophilin-2 (PKP2) are the most common cause of familial Arrhythmogenic Right Ventricular Cardiomyopathy, a disease characterized by ventricular arrhythmias, sudden death, and progressive fibrofatty cardiomyopathy. The relation
Marina Cerrone, Chantal J. M. van Opbergen, Kabir Malkani, Natasha Irrera, Natasha Irrera, Mingliang Zhang, Toon A. B. Van Veen, Bruce Cronstein, Mario Delmar   +8 more
doaj   +1 more source

E-cadherin binds to desmoglein to facilitate desmosome assembly

eLife, 2018
Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the
Omer Shafraz, Matthias Rübsam, Sara N Stahley, Amber L Caldara, Andrew P Kowalczyk, Carien M Niessen, Sanjeevi Sivasankar   +6 more
doaj   +1 more source

Desmin variants: Trigger for cardiac arrhythmias?

Frontiers in Cell and Developmental Biology, 2022
Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su, Wei Su, Stan W. van Wijk, Stan W. van Wijk, Bianca J. J. M. Brundel, Bianca J. J. M. Brundel   +5 more
doaj   +1 more source

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin

Frontiers in Immunology, 2022
Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3.
Desalegn Tadesse Egu, Thomas Schmitt, Jens Waschke   +2 more
doaj   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source