Results 41 to 50 of about 14,857 (218)

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin

Frontiers in Immunology, 2022
Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3.
Desalegn Tadesse Egu, Thomas Schmitt, Jens Waschke   +2 more
doaj   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source

Desmosomes in the testis

, 2011
Desmosomes are cell-cell junctions that link to cytoplasmic intermediate filaments, and they are known to mediate robust and stable adhesion in organs such as the skin and heart.
Dolores D. Mruk, C. Yan Cheng, Cheng, C. Yan, Mruk, Dolores D.   +3 more
core   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin

Frontiers in Immunology, 2019
Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
Dyah A. M. Oktarina, Dyah A. M. Oktarina, Ena Sokol, Duco Kramer, Marcel F. Jonkman, Hendri H. Pas   +5 more
doaj   +1 more source

The Desmin Mutation DES-c.735G>C Causes Severe Restrictive Cardiomyopathy by Inducing In-Frame Skipping of Exon-3

Biomedicines, 2021
Currently, little is known about the genetic background of restrictive cardiomyopathy (RCM). Herein, we screened an index patient with RCM in combination with atrial fibrillation using a next generation sequencing (NGS) approach and identified the ...
Andreas Brodehl, Carsten Hain, Franziska Flottmann, Sandra Ratnavadivel, Anna Gaertner, Bärbel Klauke, Jörn Kalinowski, Hermann Körperich, Jan Gummert, Lech Paluszkiewicz, Marcus-André Deutsch, Hendrik Milting   +11 more
doaj   +1 more source

Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration

Frontiers in Immunology
PurposeRegulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation and promoting re-epithelialization ...
Idan Farber, Idan Farber, Muhammad Wated, Ronen Schuster, Lihie Sheffer, Yuval Anav, Navit Ogen-Shtern, Navit Ogen-Shtern, Alexandra Tsitrina, Diya Tacruri, Anna Bunin, Noah Benjamin Nagar, Maayan Hagbi Bal, Tomer Eliyahu, Dor Halpern, Dor Halpern, Boris Knyazer, Samuel Cohen, Sabri El-Saied, Eli C. Lewis, Eldad Silberstein, Erez Tsumi   +21 more
doaj   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

The desmosome and pemphigus

Histochemistry and Cell Biology, 2008
Desmosomes are patch-like intercellular adhering junctions ("maculae adherentes"), which, in concert with the related adherens junctions, provide the mechanical strength to intercellular adhesion. Therefore, it is not surprising that desmosomes are abundant in tissues subjected to significant mechanical stress such as stratified epithelia and ...
openaire   +2 more sources

A Monoclonal Antibody Recognizing Desmosomes: Use in Human Pathology

, 1985
A mouse monoclonal IgG1 antibody that recognizes desmosomes in human tissues has been isolated and characterized. DP1 recognizes desmoplakin I (250 kD) in immunoblots of partially purified desmosome preparations.
Weber, Klaus, Weber, K., Osborn, Mary, Osborn, M.   +3 more
core   +1 more source