Results 11 to 20 of about 14,267 (224)

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Spindler, Volker, Vigh, Balázs, Waschke, Jens   +5 more
core   +13 more sources

Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]

BMC Oral Health
Background Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Doaa Abdelwadood, Yasmine Ahmed Fouad, Nashwa El-Khazragy, Ahmed Elsayed Hamed Amr   +3 more
doaj   +2 more sources

Desmoglein autoantibodies and disease severity in pemphigus patients – correlations and discrepancies [PDF]

Folia Medica, 2023
Aim: To assess the correlation between the levels of anti-desmoglein-1 and anti-desmoglein-3 autoantibodies and disease severity in pemphigus patients.
Zhaneta H. Zhelyazkova, Tsvetana I. Abadjieva, Petya A. Gardjeva, Mariana A. Murdjeva, Tsonka M. Miteva-Katrandzhieva   +4 more
doaj   +3 more sources

HLA class II antigens in Croatian patients with pemphigus vulgaris and their correlation with anti-desmoglein antibodies

Frontiers in Immunology, 2023
Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić, Ines Lakoš Jukić, Mislav Mokos, Branka Marinović, Branka Marinović   +4 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. [PDF]

PLoS ONE, 2014
During development and progression of malignant melanoma, an important role has been attributed to alterations of cell-cell adhesions, in particular, to a "cadherin switch" from E- to N-cadherin.
Wiebke K Peitsch, Yvette Doerflinger, Reiner Fischer-Colbrie, Volker Huck, Alexander T Bauer, Jochen Utikal, Sergij Goerdt, Stefan W Schneider   +7 more
doaj   +1 more source

Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4

Frontiers in Immunology, 2021
Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact
Tamara Moreno-Sosa, María Belén Sánchez, Elisa Olivia Pietrobon, Elisa Olivia Pietrobon, Juan Manuel Fernandez-Muñoz, Felipe Carlos Martín Zoppino, Flavia Judith Neira, María José Germanó, Diego Esteban Cargnelutti, Alicia Carolina Innocenti, Graciela Alma Jahn, Susana Ruth Valdez, Susana Ruth Valdez, Juan Pablo Mackern-Oberti, Juan Pablo Mackern-Oberti   +14 more
doaj   +1 more source

Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study

Van Tıp Dergisi, 2021
INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın, Ayşe Mine Gök, Tuğba Kevser Uzunçakmak, Zekayi Kutlubay   +3 more
doaj   +1 more source

Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]

Archives of Dermatology, 1999
To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
K, Ishii, M, Amagai, A, Komai, T, Ebihara, T P, Chorzelski, S, Jablonska, K, Ohya, T, Nishikawa, T, Hashimoto   +8 more
openaire   +2 more sources

A Novel In Vivo Active Pemphigus Model Targeting Desmoglein1 and Desmoglein3: A Tool Representing All Pemphigus Variants

Biology, 2023
Background: Pemphigus is a life-threatening blistering autoimmune disease. Several forms, characterized by the presence of autoantibodies against different autoantigens, have been described.
Roberta Lotti, Claudio Giacinto Atene, Emma Dorotea Zanfi, Matteo Bertesi, Carlo Pincelli, Tommaso Zanocco-Marani   +5 more
doaj   +1 more source