Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion [PDF]
PLoS ONE, 2013 Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed.
Hartlieb, Eva +5 more
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Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]
Journal of Investigative Dermatology, 2002 The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus. To validate this hypothesis genetically, we used desmoglein-3 knockout mice (DSG3-/-) that lose their telogen hair ...
Hanakawa, Yasushi +2 more
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Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
Advanced Biomedical Research, 2016 Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis.
Fariba Iraji +6 more
doaj +2 more sources
Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up [PDF]
Clinical and Developmental Immunology, 2009 The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni-Fortina +6 more
doaj +5 more sources
Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor [PDF]
Dermatology Research and Practice, 2012 Modulation of cell : cell junctions is a key event in cutaneous wound repair. In this study we report that activation of the epidermal growth factor (EGF) receptor disrupts cel : cell adhesion, but with different kinetics and fates for the desmosomal ...
Miquella G. Chavez +5 more
doaj +2 more sources
Desmoglein as a Target in Skin Disease and Beyond [PDF]
Journal of Investigative Dermatology, 2012 Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes ...
Amagai, Masayuki, Stanley, John R.
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on DSG2 (desmoglein 2), with data on DNA, on the protein encoded, and where the gene is implicated.
M Yashiro, Yashiro, M
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Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease [PDF]
Scientific Reports, 2023 Autoantibodies to desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) in people. ARVC is a common disease in the Boxer dog.
Ashley L. Walker +6 more
doaj +2 more sources
Desmoglein ELISA in the Diagnosis of Pemphigus and Its Correlation with the Severity of Pemphigus Vulgaris [PDF]
Iranian Journal of Allergy, Asthma and Immunology, 2009 Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigus diseases. Our objective was to assess the value of ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris.
Mortazavi Hossein +8 more
doaj +1 more source
Investigation of SNPs in the porcine desmoglein 1 gene [PDF]
BMC Veterinary Research, 2007 Background Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S.
Andresen Lars +2 more
doaj +2 more sources