Results 31 to 40 of about 10,060 (207)
Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model
Frontiers in Medicine, 2022 Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine +14 more
doaj +1 more source
Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic
Biomedicines, 2021 Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin ...
Branka Marinović +3 more
doaj +1 more source
Genetic Evidence for a Novel Human Desmosomal Cadherin, Desmoglein 4 [PDF]
, 2003 Desmosomes are essential adhesion structures in most epithelia that link the intermediate filament network of one cell to its neighbor, thereby forming a strong bond.
Bower, Christopher +3 more
core +1 more source
Anti-Desmocollin Autoantibodies in Autoimmune Blistering Diseases
Frontiers in Immunology, 2021 The presence of anti-desmocollin (Dsc) antibodies is rarely described in autoimmune blistering diseases patients. Moreover, several clinical phenotypes of pemphigus may be associated with these antibodies.
Xavier Bosch-Amate +4 more
doaj +1 more source
Evaluation of Desmoglein 1 and Desmoglein 3 Autoantibodies in Oral Cancer: A Pilot Study
Journal of Indian Academy of Oral Medicine and Radiology, 2023 Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis. The alterations in the role of desmosomal components due to autoantibodies to desmoglein 1 (DSG 1)
Pavan Kumar Yellarthi +4 more
openaire +2 more sources
The Anti-Desmoglein 1 Autoantibodies in Pemphigus Vulgaris Sera are Pathogenic [PDF]
, 1999 Pemphigus vulgaris and pemphigus foliaceus are two closely related, but clinically and histologically distinct, autoimmune skin diseases. The autoantigens for pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively. The
Ding, Xiang +4 more
core +1 more source
Desmoglein-1, differentiation, and disease [PDF]
Journal of Clinical Investigation, 2013 Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
Christoph M, Hammers, John R, Stanley
openaire +2 more sources
Indian Journal of Dermatology, 2022 Background: Pemphigus is a group of auto-immune blistering disorders, characterised clinically by mucocutaneous blisters and erosions and histopathologically by intra-epidermal acantholysis.
Ghanshyam Verma +5 more
doaj +1 more source
Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]
Egyptian Journal of Medical Research, 2022 There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie +3 more
doaj +1 more source
Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs
Anatolian Journal of Cardiology, 2023 Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang +6 more
doaj +1 more source