Results 31 to 40 of about 7,533 (183)
Frontiers in Immunology, 2023 Autoimmune blistering diseases (AIBD) are paradigms of autoantibody-mediated organ-specific autoimmune disorders that involve skin and/or mucous membranes.
Shirin Emtenani +5 more
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Identification of Desmoglein as a Cadherin and Analysis of Desmoglein Domain Structure
Journal of Investigative Dermatology, 2007 In the 1980s and early 1990s, the ability to clone complementary DNA (cDNA) resulted in great advances in cell biology, including our understanding of cell adhesion. Cloning the cDNA encoding desmosomal molecules, and the determination of their deduced amino-acid sequences, provided novel insights into their structure and function. It had been shown by
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Desmogleins and Desmocollins as Adhesive Molecules [PDF]
Journal of Investigative Dermatology, 2007 Following the identification of desmoglein and desmocollins as the transmembrane components of the desmosome, sequence analysis re vealed that they are members of the cadherin family of cell–cell adhesion molecules. Cadherins are characterized by the presence of conserved extracellular calcium-binding motifs.
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Frontiers in Immunology, 2019 Pemphigus is an autoimmune dermatosis in which mucocutaneous blisters are induced primarily by autoantibodies against Desmoglein (Dsg) 1 and 3. Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF)
Elias Walter +6 more
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Frontiers in Oncology, 2021 BackgroundPemphigus vulgaris (PV) is a rare and severe autoimmune blistering disorder affecting the skin and mucous membranes, characterized by the production of autoantibodies against two desmosomal adhesion proteins, desmoglein 1 and 3.
Rosalba Buquicchio +5 more
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International Journal of Trichology, 2013 Desmogleins (Dsgs) are calcium-dependent, transmembrane glycoproteins belonging to the desmosomal cadherin superfamily, which play significant roles in selective calcium ions (Ca(2+)) dependent adhesion interactions between cell surfaces. Four subtypes of Dsg have been identified.
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Desmoglein as a Target in Skin Disease and Beyond [PDF]
Journal of Investigative Dermatology, 2012 Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes ...
Amagai, Masayuki, Stanley, John R.
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Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease
Scientific Reports, 2023 Autoantibodies to desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) in people. ARVC is a common disease in the Boxer dog.
Ashley L. Walker +6 more
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Cells, 2023 Pemphigus vulgaris (PV) is a potentially lethal autoimmune bullous skin disorder caused by IgG autoantibodies against desmoglein 3 (Dsg3) and Dsg1. During the last three decades, high-dose intravenous immunoglobulins (IVIgs) have been applied as an ...
Christoph Hudemann +4 more
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Successful Treatment of Severe Adult Linear IgA Dermatosis Using Dupilumab
JEADV Clinical Practice, EarlyView.ABSTRACT Linear IgA dermatosis (LAD) is a rare autoimmune subepidermal bullous dermatosis, characterised by the presence of erythematous vesiculobullous lesions arranged in rosettes or herpetiform clusters. The standard treatment involves the administration of dapsone, followed by sulfasalazine, and general corticosteroid therapy, often in combination ...
Célia Delesalle +7 more
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