Results 11 to 20 of about 11,604 (181)
Cold Spring Harbor Perspectives in Biology, 2009 Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit ...
Emmanuella, Delva +2 more
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Journal of Cell Science, 2009 Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Tight junctions and adherens junctions (AJs) are restricted to the apical domain, where they form the epithelial barrier and organize cortical actin, respectively.
Bhushan V, Desai +2 more
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Assembly of Desmosomal Cadherins into Desmosomes is Isoform Dependent [PDF]
Journal of Investigative Dermatology, 2001 Desmosomes are intercellular adhesive junctions that exhibit cell- and differentiation-specific differences in their molecular composition. In complex epithelia, desmosomes contain multiple representatives of the desmosomal cadherin family, which includes three desmogleins and three desmocollins.
Ishii, Ken +5 more
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Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
Biomolecules, 2022 Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes.
Qian-Rui Xu +8 more
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EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation
JCI Insight, 2023 Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options.
Maria Shoykhet +13 more
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E-cadherin binds to desmoglein to facilitate desmosome assembly
eLife, 2018 Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the
Omer Shafraz +6 more
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Frontiers in Physiology, 2020 Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as ...
Sunil Yeruva +5 more
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Overview of junctional complexes during mammalian early embryonic development
Frontiers in Endocrinology, 2023 Cell-cell junctions form strong intercellular connections and mediate communication between blastomeres during preimplantation embryonic development and thus are crucial for cell integrity, polarity, cell fate specification and morphogenesis.
Ceren Canse, Ecem Yildirim, Aylin Yaba
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Pervanadate stabilizes desmosomes [PDF]
Cell Adhesion & Migration, 2008 Desmosomes are intercellular junctions responsible for strong cell-cell adhesion in epithelia and cardiac muscle. Numerous studies have shown that the other major type of epithelial cell adhesion, the adherens junction, is destabilized by src-induced tyrosine phosphorylation of two of its principal components, E-cadherin and beta-catenin.
Garrod, D. +3 more
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Frontiers in Immunology, 2020 Pemphigus is a chronic autoimmune blistering disorder, characterized by (muco-)cutaneous erosions due to autoantibodies against desmoglein 3 and/or 1. Pemphigus induction might be associated with drugs, malignancy or radiation therapy (RT); the latter ...
Franziska Schauer +6 more
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