Results 11 to 20 of about 12,510 (224)

E-cadherin binds to desmoglein to facilitate desmosome assembly [PDF]

eLife, 2018
Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the
Omer Shafraz, Matthias Rübsam, Sara N Stahley, Amber L Caldara, Andrew P Kowalczyk, Carien M Niessen, Sanjeevi Sivasankar   +6 more
doaj   +2 more sources

Arrhythmogenic Right Ventricular Dysplasia: Clinical Characteristics and Identification of Novel Desmosome Gene Mutations

Journal of the Formosan Medical Association, 2008
Background/Purpose: Desmosome gene mutations have been reported in patients with arrhythmogenic right ventricular dysplasia (ARVD). However, there are hardly any genetic studies in Asians.
Chih-Chieh Yu, Cheng-Han Yu, Chia-Hsiang Hsueh, Chi-Tung Yang, Jyh-Ming Juang, Juey-Jen Hwang, Jiunn-Lee Lin, Ling-Ping Lai   +7 more
doaj   +3 more sources

Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. [PDF]

PLoS ONE, 2014
Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation
Kaelyn Sumigray, Kang Zhou, Terry Lechler   +2 more
doaj   +2 more sources

Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation. [PDF]

Nat Genet
Desmosomes are transmembrane protein complexes that contribute to cell–cell adhesion in epithelia and other tissues. Here, we report the discovery of frequent genetic alterations in the desmosome in human cancers, with the strongest signal seen in ...
Baron M, Tagore M, Wall P, Zheng F, Barkley D, Yanai I, Yang J, Kiuru M, White RM, Ideker T.   +9 more
europepmc   +2 more sources

Disruption of TUFT1, a Desmosome-Associated protein, causes skin fragility, woolly hair, and Palmoplantar Keratoderma [PDF]

, 2023
Desmosomes are dynamic complex protein structures involved in cellular adhesion. Disruption of these structures by loss-of-function variants in desmosomal genes leads to a variety of skin- and heart-related phenotypes. In this study, we report TUFT1 as a
Silljé, H., Bolling, M., Vermeer, M., van der Molen, M., Uitterlinden, A., Dean, M., Hublin, J. ; https://orcid.org/, Giepmans, B., Slotman, J., M.W., A., Saris, J., Diercks, G., Meijer, H., van den Ouweland, Oberdorf-Maass, S., Hoes, M., Nijenhuis, M., Verlouw, J., Andrei, D., Bremer, J., Hoogeboom, A., Verkerk, A., C., P., Arp, P., Schouten, M., Willemsen, R., van der Meer, P., Kramer, D., van den Akker, Pas, H., Stoop, H., Romero-Herrera, P.   +31 more
core   +2 more sources

The Desmosome [PDF]

Cold Spring Harbor Perspectives in Biology, 2009
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit ...
Emmanuella, Delva, Dana K, Tucker, Andrew P, Kowalczyk   +2 more
openaire   +2 more sources

Desmosomes at a glance [PDF]

Journal of Cell Science, 2009
Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Tight junctions and adherens junctions (AJs) are restricted to the apical domain, where they form the epithelial barrier and organize cortical actin, respectively.
Bhushan V, Desai, Robert M, Harmon, Kathleen J, Green   +2 more
openaire   +2 more sources

KowalczykLab/Desmosome-ER: v1.0.1

, 2022
Full Changelog: https://github.com/KowalczykLab/Desmosome-ER/compare/v1.0.0...v1.0.
William Giang, NavBharathan
core   +1 more source

Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting.

, 2023
Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in ...
Payne, Aimee S, Kowalczyk, Andrew P., Kowalczyk, Andrew P, Müller, Eliane J., Müller, Eliane J, Waschke, Jens, Gerull, Brenda, Green, Kathleen J., Schmidt, Enno, Marian, Ali J, Niessen, Carien, Vielmuth, Franziska, Schlegel, Nicolas, Milting, Hendrik, Marian, Ali J., Green, Kathleen J, Payne, Aimee S., Spindler, Volker, Leube, Rudolf, Tikkanen, Ritva, Strnad, Pavel   +20 more
core   +1 more source

Assembly of Desmosomal Cadherins into Desmosomes is Isoform Dependent [PDF]

Journal of Investigative Dermatology, 2001
Desmosomes are intercellular adhesive junctions that exhibit cell- and differentiation-specific differences in their molecular composition. In complex epithelia, desmosomes contain multiple representatives of the desmosomal cadherin family, which includes three desmogleins and three desmocollins.
Ishii, Ken, Norvell, Suzanne M., Bannon, Leslie J., Amargo, Evangeline V., Pascoe, Lauren T., Green, Kathleen J.   +5 more
openaire   +2 more sources