Results 31 to 40 of about 11,604 (181)
Desmosomes in Cell Fate Determination: From Cardiogenesis to Cardiomyopathy
Cells, 2023 Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in desmosomal proteins lead to the development of arrhythmogenic cardiomyopathy (AC).
Hoda Moazzen +2 more
doaj +1 more source
ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation
Frontiers in Immunology, 2019 Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3. Recently, a genetic variant of the Suppression of tumorigenicity 18 (ST18) promoter was reported to cause ST18 up-regulation, associated with ...
Mariya Y. Radeva +9 more
doaj +1 more source
Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes [PDF]
Journal of Cell Biology, 2011 The desmosomal cadherins, desmogleins (Dsgs) and desmocollins (Dscs), comprise the adhesive core of intercellular junctions known as desmosomes. Although these adhesion molecules are known to be critical for tissue integrity, mechanisms that coordinate their trafficking into intercellular junctions to regulate their proper ratio and distribution are ...
Nekrasova, Oxana E. +5 more
openaire +4 more sources
Neural Plasticity, 1999 Adaptation or resistance of fish Mauthner cells (M-cells) to long duration (2 h) vestibular stimulation (LDS)was produced by daily brief and gradually increasing vestibular stimulation (training).
Nadezhda R. Tiras +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease which is associated with autoantibodies directed against two desmosomal proteins, desmoglein (Dsg) 3 and 1.
Maxi Hofrichter +11 more
doaj +1 more source
Frontiers in Physiology, 2012 In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj +1 more source
Cortical tension regulates desmosomal morphogenesis
Frontiers in Cell and Developmental Biology, 2022 Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch +2 more
doaj +1 more source
Desmosomal connectomics of all somatic muscles in an annelid larva
eLife, 2022 Cells form networks in animal tissues through synaptic, chemical, and adhesive links. Invertebrate muscle cells often connect to other cells through desmosomes, adhesive junctions anchored by intermediate filaments.
Sanja Jasek +6 more
doaj +1 more source
Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design
Journal of Cardiovascular Development and Disease, 2020 Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural and electrical cardiac abnormalities, including myocardial fibro-fatty replacement.
Tyler L. Stevens +5 more
doaj +1 more source
eLife, 2017 Cell junctions are scaffolds that integrate mechanical and chemical signaling. We previously showed that a desmosomal cadherin promotes keratinocyte differentiation in an adhesion-independent manner by dampening Epidermal Growth Factor Receptor (EGFR ...
Nicole Ann Najor +6 more
doaj +1 more source