Results 41 to 50 of about 13,148 (221)

Disruption of tuftelin 1, a desmosome associated protein, causes skin fragility, woolly hair and palmoplantar keratoderma [PDF]

, 2023
Desmosomes are dynamic complex protein structures involved in cellular adhesion. Disruption of these structures by loss of function variants in desmosomal genes lead to a variety of skin and heart related phenotypes.
Kramer, Duco, Hoes, Martijn F, Verlouw, Joost AM, Slotman, Johan A, Uitterlinden, André G, Schouten, Marloes, van den Akker, Peter C, Bremer, Jeroen, Saris, Jasper, Oberdorf-Maass, Silke, Vermeer, Mathilde CSC, Romero-Herrera, Pedro H, Verkerk, Annemieke JMH, Andrei, Daniela, Meijer, Hillegonda J, van den Ouweland, Ans MW, Hoogeboom, A Jeannette M, Silljé, Herman HW, Dean, M Christopher, Nijenhuis, Miranda, Diercks, Gilles FH, Pas, Hendri H, Hublin, Jean-Jacques, Stoop, Hans, Giepmans, Ben NG, van der Molen, Marije, Bolling, Maria C, Willemsen, Rob, Arp, Pascal, van der Meer, Peter   +29 more
core   +1 more source

Ultrastructure of Mauthner Cells in Fish Adapted to Long-Duration Vestibular Stimulation and the Effect of Ethanol

Neural Plasticity, 1999
Adaptation or resistance of fish Mauthner cells (M-cells) to long duration (2 h) vestibular stimulation (LDS)was produced by daily brief and gradually increasing vestibular stimulation (training).
Nadezhda R. Tiras, Georgy V. Zherdev, Dmitry A. Moshkov   +2 more
doaj   +1 more source

ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation

Frontiers in Immunology, 2019
Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3. Recently, a genetic variant of the Suppression of tumorigenicity 18 (ST18) promoter was reported to cause ST18 up-regulation, associated with ...
Mariya Y. Radeva, Elias Walter, Ramona Alexandra Stach, Amir S. Yazdi, Amir S. Yazdi, Nicolas Schlegel, Ofer Sarig, Eli Sprecher, Eli Sprecher, Jens Waschke   +9 more
doaj   +1 more source

Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes [PDF]

Journal of Cell Biology, 2011
The desmosomal cadherins, desmogleins (Dsgs) and desmocollins (Dscs), comprise the adhesive core of intercellular junctions known as desmosomes. Although these adhesion molecules are known to be critical for tissue integrity, mechanisms that coordinate their trafficking into intercellular junctions to regulate their proper ratio and distribution are ...
Nekrasova, Oxana E., Amargo, Evangeline V., Smith, William O., Chen, Jing, Kreitzer, Geri E., Green, Kathleen J.   +5 more
openaire   +4 more sources

Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice

Frontiers in Immunology, 2018
Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease which is associated with autoantibodies directed against two desmosomal proteins, desmoglein (Dsg) 3 and 1.
Maxi Hofrichter, Jenny Dworschak, Shirin Emtenani, Jana Langenhan, Fanny Weiß, Lars Komorowski, Detlef Zillikens, Winfried Stöcker, Christian Probst, Enno Schmidt, Enno Schmidt, Stephanie Goletz   +11 more
doaj   +1 more source

Cortical tension regulates desmosomal morphogenesis

Frontiers in Cell and Developmental Biology, 2022
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch, Jana Schieren, Rudolf E. Leube   +2 more
doaj   +1 more source

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

Desmosomal connectomics of all somatic muscles in an annelid larva

eLife, 2022
Cells form networks in animal tissues through synaptic, chemical, and adhesive links. Invertebrate muscle cells often connect to other cells through desmosomes, adhesive junctions anchored by intermediate filaments.
Sanja Jasek, Csaba Verasztó, Emelie Brodrick, Réza Shahidi, Tom Kazimiers, Alexandra Kerbl, Gáspár Jékely   +6 more
doaj   +1 more source

Desmosome Signaling: INHIBITION OF p38MAPK PREVENTS PEMPHIGUS VULGARIS IgG-INDUCED CYTOSKELETON REORGANIZATION [PDF]

, 2005
In the human autoimmune blistering disease pemphigus vulgaris (PV) pathogenic antibodies bind the desmosomal cadherin desmoglein-3 (dsg3), causing epidermal cell-cell detachment (acantholysis).
Chua, Michael P., Rubenstein, David S., Liu, Zhi, Berkowitz, Paula, Hu, Peiqi, Enghild, Jan J., Diaz, Luis A.   +6 more
core   +1 more source

Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design

Journal of Cardiovascular Development and Disease, 2020
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural and electrical cardiac abnormalities, including myocardial fibro-fatty replacement.
Tyler L. Stevens, Michael J. Wallace, Mona El Refaey, Jason D. Roberts, Sara N. Koenig, Peter J. Mohler   +5 more
doaj   +1 more source