Results 61 to 70 of about 12,510 (224)
Pediatric Discovery, EarlyView.ABSTRACT Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first‐line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways.
Tangqiaochu Gan, Zhou Fu, Chao Niu
wiley +1 more source
miR-195-5p as Regulator of γ-Catenin and Desmosome Junctions in Colorectal Cancer
, 2023 Desmosomes play a key role in the regulation of cell adhesion and signaling. Dysregulation of the desmosome complex is associated with the loss of epithelial cell polarity and disorganized tissue architecture typical of colorectal cancer (CRC).
Viviana Scalavino +4 more
core +1 more source
Desmosome assembly and dynamics [PDF]
Trends in Cell Biology, 2013 Desmosomes are intercellular junctions that anchor intermediate filaments (IFs) to the plasma membrane, forming a supracellular scaffold that provides mechanical resilience to tissues. This anchoring function is accomplished by specialized members of the cadherin family and associated cytoskeletal linking proteins, which together form a highly ...
Oxana, Nekrasova, Kathleen J, Green
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Desmosome assembly, homeostasis, and desmosomal disease
Cell Health and Cytoskeleton, 2016 Nicola Cirillo1,2 1Melbourne Dental School and Oral Health CRC, The University of Melbourne, Melbourne, VIC, Australia; 2Research Unit, Centre for Innovation, Research, Education, and Health (IRIS), Caposele, Italy Abstract: Cell–cell adhesion is involved in all aspects of tissue behavior in multicellular organisms, from tissue morphogenesis (
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Intermediate Filaments and Polarization in the Intestinal Epithelium
Cells, 2016 The cytoplasmic intermediate filament cytoskeleton provides a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features.
Richard A. Coch, Rudolf E. Leube
doaj +1 more source
Allergy, EarlyView.We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen +5 more
wiley +1 more source
Keratin Isotypes Control Desmosome Stability and Dynamics through PKCα
, 2016 Expression and interaction of desmosomal components and keratins provide stable cell cohesion and protect the epidermis against various types of stress.
Homberg, Melanie +2 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick +7 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source