Results 81 to 90 of about 11,604 (181)

Desmosomes in pemphigus vegetans

Acta Dermato-Venereologica, 1981
Desmosomes of a patient suffering from pemphigus vegetans were studied by electron microscopy and analysed by morphometry, The desmosomes were fewer in the patient´s skin than in healthy individuals. The desmosomes of the patient were thin and short, showing pathological ultrastructures, viz.
T, Higashida, H, Hino, T, Kobayasi
openaire   +2 more sources

Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus

Frontiers in Immunology, 2018
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly ...
Franziska Vielmuth, Elias Walter, Michael Fuchs, Mariya Y. Radeva, Fanny Buechau, Thomas M. Magin, Volker Spindler, Jens Waschke   +7 more
doaj   +1 more source

Desmosomes and disease.

Histology and histopathology, 1997
Considerable progress has been made in our knowledge of desmosomes and their components. Molecular cloning of the desmosomal glycoproteins has established that desmoglein 1 and desmoglein 3 are targets for autoantibodies in the blistering diseases pemphigus foliaceus and pemphigus vulgaris respectively.
openaire   +2 more sources

Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell–Cell Junctions

Frontiers in Cell and Developmental Biology, 2019
Cell–cell adhesion plays a key role in the maintenance of the epithelial barrier and apicobasal cell polarity, which is crucial for homeostasis. Disruption of cell–cell adhesion is a hallmark of numerous pathological conditions, including invasive ...
Diana Schuhmacher, Jean-Marie Sontag, Jean-Marie Sontag, Estelle Sontag, Estelle Sontag   +4 more
doaj   +1 more source

The role of desmosomes in carcinogenesis

OncoTargets and Therapy, 2017
Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression.
Guangxin Zhou, Linlin Yang, Ashley Gray, Amit Kumar Srivastava, Cuiping Li, Gongwen Zhang, Tiantian Cui   +6 more
openaire   +4 more sources

The Diagnostic and Prognostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy

JACC: Advances
Background: Electrocardiographic findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) have been limited to small studies. Objectives: The authors aimed to analyze the electrocardiogram (ECG) characteristics of ALVC, to correlate ECG with ...
Leonardo Calò, MD, Cinzia Crescenzi, MD, Andrea Di Marco, MD, PhD, Francesca Fanisio, MD, Fabiana Romeo, MD, Alessio Gargaro, MSc, Annamaria Martino, MD, PhD, Chiara Cappelletto, MD, Marco Merlo, MD, Mattia Targetti, MD, Elisabetta Toso, MD, Federica Toto, MD, Maria Beatrice Musumeci, MD, Giacomo Tini, MD, Michele Ciabatti, MD, Matteo Stefanini, MD, Stefano Canestrelli, MD, Elisa Fedele, MD, Chiara Lanzillo, MD, PhD, Armando Fusco, MD, PhD, Federica Carla Sangiuolo, MD, PhD, Cinzia Radesich, MD, Maria Perotto, MD, Maurizio Pieroni, MD, Ruggiero Mango, MD, PhD, Alessio Gasperetti, MD, PhD, Camillo Autore, MD, Michela Casella, MD, PhD, Antonio Dello Russo, MD, PhD, Davide Stolfo, MD, PhD, Mikael Laredo, MD, PhD, Estelle Gandjbakhch, MD, PhD, Maddalena Graziosi, MD, PhD, Elena Biagini, MD, PhD, Costantina Catalano, MD, Ludovica Barile, MD, Fabrizio Drago, MD, Marianna Cicenia, MD, Anwar Baban, MD, PhD, Gemma Pelargonio, MD, PhD, Maria Lucia Narducci, MD, Federica Re, MD, Giovanni Peretto, MD, Elena Paiotti, MD, Carles Diez Lopez, MD, Iacopo Olivotto, MD, Fiorenzo Gaita, MD, Gianfranco Sinagra, MD, Giuseppe Novelli, MD, PhD   +48 more
doaj   +1 more source

Diversity of Intercellular Communication Modes: A Cancer Biology Perspective

Cells
From the moment a cell is on the path to malignant transformation, its interaction with other cells from the microenvironment becomes altered. The flow of molecular information is at the heart of the cellular and systemic fate in tumors, and various ...
Thanzeela Ebrahim, Abdul Shukkur Ebrahim, Mustapha Kandouz   +2 more
doaj   +1 more source

Biochemical Characterization of the Desmosome [PDF]

Journal of Investigative Dermatology, 2007
Bass-Zubek, Amanda E., Green, Kathleen J.   +1 more
openaire   +3 more sources

A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease

Cells
Arrhythmogenic cardiomyopathy (ACM) is a genetic myocardial disorder marked by progressive cardiomyocyte loss, fibro-fatty replacement, ventricular arrhythmias, and risk of sudden cardiac death.
Gallage H. D. N. Ariyaratne, Andrea Villatore, Giovanni Peretto, Stephen P. Chelko   +3 more
doaj   +1 more source

Desmoplakin mutation underlying autosomal dominant arrhythmogenic cardiomyopathy, palmoplantar keratoderma, and curly hair

JAAD Case Reports, 2023
Colin Kincaid, BS, Luke Horton, MD, Brian Cheung, MD, Ilhan Esse, BA, Irmina Gradus-Pizlo, MD, Natasha Atanaskova Mesinkovska, MD, PhD   +5 more
doaj   +1 more source