Results 71 to 80 of about 12,510 (224)
Role of PKC and ERK Signaling in Epidermal Blistering and Desmosome Regulation in Pemphigus [PDF]
, 2019 Desmosomes reinforce cohesion of epithelial cells at the interface between adjacent cells. They include the cadherin-type adhesion molecules desmoglein 1 (Dsg1) and Dsg3.
Kugelmann, Daniela +2 more
core +1 more source
, 2023 Desmosomes are essential structures for ensuring tissue functions, and their deregulation is involved in the development of colorectal cancer (CRC). JUP (γ-catenin) is a desmosome adhesion component that also acts as a signaling hub, suggesting its
Viviana Scalavino +7 more
core +1 more source
Brain Pathology, EarlyView.Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira +19 more
wiley +1 more source
, 2005 In the human autoimmune blistering disease pemphigus vulgaris (PV) pathogenic antibodies bind the desmosomal cadherin desmoglein-3 (dsg3), causing epidermal cell-cell detachment (acantholysis).
Chua, Michael P. +6 more
core +1 more source
Desmosome dualism: most of the junction is stable but a plakophilin moiety is persistently dynamic. [PDF]
, 2021 Desmosomes, strong cell-cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes and mechanically integrate cells across tissues, dissipating mechanical stress.
Liebl, David +14 more
core +1 more source
Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus
Frontiers in Immunology, 2018 Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes
Franziska Vielmuth +2 more
doaj +1 more source
Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design
Journal of Cardiovascular Development and Disease, 2020 Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural and electrical cardiac abnormalities, including myocardial fibro-fatty replacement.
Tyler L. Stevens +5 more
doaj +1 more source
European S2k guidelines on management of autoimmune blistering diseases in children and adolescents
Journal of the European Academy of Dermatology and Venereology, EarlyView.Autoimmune blistering disorders (AIBDs) in children are rare, challenging to diagnose and treat and often require immunosuppressants. Until now, no paediatric care guidelines existed. The EADV Task Force for AIBDs has developed the consensus‐based recommendations, enabling physicians to adopt a uniform, tailored treatment strategy to improve outcomes ...
A. Nanda +31 more
wiley +1 more source
Different roles of cadherins in the assembly and structural integrity of the desmosome complex.
, 2014 International audience: Adhesion between cells is established by the formation of specialized intercellular junctional complexes, such as desmosomes. Desmosomes comprise two members of the cadherin superfamily of cell adhesion proteins, desmocollin (Dsc)
Shafraz, Omer +7 more
core +1 more source
Darier disease—A review highlighting new insights from the Darier Disease International Task Force
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz +49 more
wiley +1 more source