Results 91 to 100 of about 12,510 (224)

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Bettina Kempf, Partilla, Miriam, Jens Waschke, Hartlieb, Eva, Waschke, Jens, Kempf, Bettina, Eva Hartlieb (103934), Vigh, Balázs, Miriam Partilla, Miriam Partilla (103942), Balázs Vigh, Bettina Kempf (103938), Eva Hartlieb, Volker Spindler (103952), Balázs Vigh (103947), Jens Waschke (103956), Spindler, Volker, Volker Spindler   +17 more
core   +1 more source

Structure of Desmosomes

, 2015
Desmosomes are cell-cell junctions that connect neighboring cells to their intermediate filament networks that serve to provide mechanical strength to the tissue. Major proteins that compose desmosomes are desmogleins, desmocollins, plakoglobin, plakophilins and desmoplakin.
openaire   +2 more sources

Autoantibodies in Patients With Arrhythmogenic Cardiomyopathy Activate GSK‐3β, Resulting in a Loss of Cardiomyocyte Cohesion

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Background Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac desmosome disease, as more than 50% of affected patients carry pathogenic variants in desmosome protein‐coding genes. In this study, we focused on the role and mechanisms of pathogenic and non‐pathogenic autoantibodies against intercalated disc (ICD) proteins such as ...
Soumyata Pathak, Konstanze Stangner, Ellen Kempf, Sina Moztarzadeh, Matthias Hiermaier, Stephanie Wider, Marlene Rauschmayer, Tatjana Williams, Andreas Stengl, Brenda Gerull, Ruth Biller, Sebastian Clauss, Stefan Kääb, Tomo Šarić, Sunil Yeruva, Jens Waschke   +15 more
wiley   +1 more source

Pathophysiology of the desmosome

, 2009
Tissues are composed of cells, and one essential requirement for overall integrity is that the cells should be bound together firmly. The property that binds cells together is called cell adhesion.
Cirillo, N
core  

Model for membrane rafts as platforms for desmosome regulation.

, 2014
Desmosomal protein targeting to membrane rafts is required for the extensive clustering driven by cadherin ectodomain and plaque protein interactions during assembly that yields a mature and tightly packed desmosome. When adhesion is compromised (i.e. in
Sara N. Stahley (114972), Victor Faundez (263046), Andrew P. Kowalczyk (114982), Michael Koval (414530), Alexa L. Mattheyses (517220), Masataka Saito (114969)   +5 more
core   +1 more source

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome [PDF]

, 2013
Contains fulltext : 118008.pdf (Publisher’s version ) (Open Access)Ankyloblepharon, ectodermal defects, cleft lip/palate (AEC) syndrome is a rare autosomal dominant disorder caused by mutations in the p63 gene, essential for embryonic ...
R. Ambrosio, Thomason, Helen A, De Rosa, L., H. Zhou, MISSERO, Caterina, S. Getsios, Zhou, Huiqing, Ambrosio, R., H. A. Thomason, De rosa, Laura, Ferone, G., H. van Bokhoven, Getsios, S., Antonini, D., Mollo, Maria Rosaria, J. Dixon, Bokhoven, H. van, Ferone, Giustina, Missero, C., SALVATORE, DOMENICO, Dixon, Jill; id_orcid, Dixon, Jill, Ambrosio, Raffaele, Salvatore, D., L. De Rosa, Thomason, H.A., Dixon, J., ANTONINI, Dario, Thomason, Helen A., Getsios, Spiro, Mollo, M.R., van Bokhoven, Hans, G. Ferone, M. R. Mollo   +33 more
core   +1 more source

Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris

Frontiers in Immunology, 2018
Pemphigus vulgaris (PV) is a potentially lethal autoimmune disease characterized by blister formation of the skin and mucous membranes and is caused by autoantibodies against desmoglein (Dsg) 1 and Dsg3.
Elisabeth Schlögl, Mariya Y. Radeva, Franziska Vielmuth, Camilla Schinner, Jens Waschke, Volker Spindler, Volker Spindler   +6 more
doaj   +1 more source

Elevated desmoglein‐2 expression in multiple myeloma is a prognostic marker across genomic subtypes with impact on high‐risk cytogenetics and a distinct gene expression profile

British Journal of Haematology, EarlyView.
Barbara J. McClure, John Toubia, Charlotte E. J. Toomes, O. Giles Best, Angelina Yong, Cindy H. Lee, Claudine S. Bonder, Chung Hoow Kok   +7 more
wiley   +1 more source

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype (Software)

, 2021
These are the MATLAB scripts used to analyze (1) actin alignment in immunofluorescrently labeled images of engineered cardiac tissues, (2) calcium dynamics in engineered cardiac tissues, and (3) contractility of dynamic engineered heart tissues (dyn-EHTs)
Feinberg, Adam W., Tashman, Joshua W., Batalov, Ivan, Shiwarski, Daniel J., Bliley, Jacqueline M.   +4 more
core   +1 more source