Results 91 to 100 of about 13,148 (221)

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, Volume 249, Issue 4, Page 950-969, October 2026.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

The desmosomal cadherin Desmoglein-2 controls extracellular matrix expression and remodeling via NF-κB signaling in keratinocytes

Frontiers in Cell and Developmental Biology
Desmogleins are transmembrane cadherin proteins and obligate members of the desmosome, a cell-cell adhesion complex which connects adjacent cells and provides structural integrity to tissues.
Sadie E. Hunter, Zara T. Patel, Beatriz Mateo, Joshua M. Powers, Austin Y. Shull, Adi D. Dubash   +5 more
doaj   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, Volume 13, Issue 49, 3 September 2026.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Pathophysiology of the desmosome

, 2009
Tissues are composed of cells, and one essential requirement for overall integrity is that the cells should be bound together firmly. The property that binds cells together is called cell adhesion.
Cirillo, N
core  

Calcium-independent desmosome adhesion : acquisition, maintenance and modulation

, 1994
Desmosomal adhesion is known to be calcium dependent and desmosomal glycoproteins belong to the cadherin superfamily of adhesion molecules. Thus, MDCK cells in short term cultures lose cell-cell adhesion when extracellular calcium concentrations are ...
Lloyd, Susan
core   +1 more source

Regulation of mechanical intercellular junctions and components of the mitochondrial electron transport chain and the TCA cycle in the hypertrophic heart by pyridostigmine or trandolapril

Frontiers in Molecular Biosciences
The conventional approach to studying hypertension and cardiac hypertrophy primarily focuses on electrochemical signaling mediated by gap junctions. However, mechanical adherens junctions also contribute to hypertrophy through activation of β-catenin ...
Zdenka Drastichova, Lucie Hejnova, Almos Boroš, Michal Behuliak, Jiri Novotny   +4 more
doaj   +1 more source

Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus

Frontiers in Immunology, 2018
Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes
Franziska Vielmuth, Volker Spindler, Jens Waschke   +2 more
doaj   +1 more source

Ultrastructure of Vitellogenic Ovarian Follicles and Morphogenesis of the Oocyte Envelope in the Eurasian Ruffe (Gymnocephalus cernua Linnaeus 1758) (Teleostei, Perciformes)

Journal of Morphology, Volume 287, Issue 9, September 2026.
Ruffe's vitellogenic ovarian follicles consists of a single oocyte surrounded by follicular cells, a basal lamina, and thecal cells. The oocytes are polarized and covered by a primary envelope. The follicular cells diversify into micropylar and mainbody cells. The latter have dark and bright cytoplasms.
Monika Żelazowska, Roman Kujawa
wiley   +1 more source

Model for membrane rafts as platforms for desmosome regulation.

, 2014
Desmosomal protein targeting to membrane rafts is required for the extensive clustering driven by cadherin ectodomain and plaque protein interactions during assembly that yields a mature and tightly packed desmosome. When adhesion is compromised (i.e. in
Sara N. Stahley (114972), Victor Faundez (263046), Andrew P. Kowalczyk (114982), Michael Koval (414530), Alexa L. Mattheyses (517220), Masataka Saito (114969)   +5 more
core   +1 more source

KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules [PDF]

, 2009
Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been reported, including regulation of desmosome assembly, embryonic tissue morphogenesis and ...
F. M. Watt, L. M. Sevilla, R. Nachat, Nachat, Rachida, Watt, FM, Nachat, R, Sevilla, LM, Groot, KR, Chhatriwala, Mariya, Groot, Karen R, Chhatriwala, M, M. Chhatriwala, Watt, Fiona M; id_orcid, S. Cipolat, K. R. Groot, Cipolat, Sara, Sevilla, Lisa M, Cipolat, S   +17 more
core   +1 more source