Results 21 to 30 of about 12,510 (224)

KowalczykLab/Desmosome-ER: v1.0.0

, 2022
First release for generating Zenodo ...
William Giang
core   +1 more source

EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation

JCI Insight, 2023
Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options.
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kääb, Sebastian Clauss, Dominik Schüttler, Jens Waschke, Sunil Yeruva   +13 more
doaj   +1 more source

Pervanadate stabilizes desmosomes [PDF]

Cell Adhesion & Migration, 2008
Desmosomes are intercellular junctions responsible for strong cell-cell adhesion in epithelia and cardiac muscle. Numerous studies have shown that the other major type of epithelial cell adhesion, the adherens junction, is destabilized by src-induced tyrosine phosphorylation of two of its principal components, E-cadherin and beta-catenin.
Garrod, D., Fisher, C., Smith, A., Nie, Z.   +3 more
openaire   +3 more sources

Dsg2 Upregulation as a Rescue Mechanism in Pemphigus

Frontiers in Immunology, 2020
In pemphigus vulgaris (PV), autoantibodies directed against the desmosomal cadherin desmoglein (Dsg) 3 cause loss of intercellular adhesion. It is known that Dsg3 interactions are directly inhibited by autoantibody binding and that Dsg2 is upregulated in
Anna M. Sigmund, Letyfee S. Steinert, Desalegn T. Egu, Franziska C. Bayerbach, Jens Waschke, Franziska Vielmuth   +5 more
doaj   +1 more source

Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma

Biomolecules, 2022
Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes.
Qian-Rui Xu, Xiao-Hui Du, Ting-Ting Huang, Yu-Chun Zheng, Yu-Ling Li, Dan-Yi Huang, Hao-Qiang Dai, En-Min Li, Wang-Kai Fang   +8 more
doaj   +1 more source

KowalczykLab/Desmosome-ER: Nature Cell Biology accepted

, 2023
This release is meant to be the final version for the Nature Cell Biology manuscript Bharathan, et al.
William Giang, NavBharathan
core   +1 more source

Cortical tension regulates desmosomal morphogenesis

Frontiers in Cell and Developmental Biology, 2022
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch, Jana Schieren, Rudolf E. Leube   +2 more
doaj   +1 more source

Desmosomes In Vivo [PDF]

Dermatology Research and Practice, 2010
The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium‐independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, calcium‐dependent desmosomes, although hyperadhesion can ...
openaire   +3 more sources

Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.

PLoS Genetics, 2010
Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis.
Veronica G Beaudry, Dadi Jiang, Rachel L Dusek, Eunice J Park, Stevan Knezevich, Katie Ridd, Hannes Vogel, Boris C Bastian, Laura D Attardi   +8 more
doaj   +1 more source

Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes

Frontiers in Physiology, 2020
Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as ...
Sunil Yeruva, Ellen Kempf, Desalegn Tadesse Egu, Heinrich Flaswinkel, Daniela Kugelmann, Jens Waschke   +5 more
doaj   +1 more source