Results 21 to 30 of about 13,148 (221)
Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
Biomolecules, 2022 Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes.
Qian-Rui Xu +8 more
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KowalczykLab/Desmosome-ER: v1.0.0
, 2022 First release for generating Zenodo ...
William Giang
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Pervanadate stabilizes desmosomes [PDF]
Cell Adhesion & Migration, 2008 Desmosomes are intercellular junctions responsible for strong cell-cell adhesion in epithelia and cardiac muscle. Numerous studies have shown that the other major type of epithelial cell adhesion, the adherens junction, is destabilized by src-induced tyrosine phosphorylation of two of its principal components, E-cadherin and beta-catenin.
Garrod, D. +3 more
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Overview of junctional complexes during mammalian early embryonic development
Frontiers in Endocrinology, 2023 Cell-cell junctions form strong intercellular connections and mediate communication between blastomeres during preimplantation embryonic development and thus are crucial for cell integrity, polarity, cell fate specification and morphogenesis.
Ceren Canse, Ecem Yildirim, Aylin Yaba
doaj +1 more source
Frontiers in Physiology, 2020 Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as ...
Sunil Yeruva +5 more
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Frontiers in Immunology, 2020 Pemphigus is a chronic autoimmune blistering disorder, characterized by (muco-)cutaneous erosions due to autoantibodies against desmoglein 3 and/or 1. Pemphigus induction might be associated with drugs, malignancy or radiation therapy (RT); the latter ...
Franziska Schauer +6 more
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Frontiers in Immunology, 2022 Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt +7 more
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Dermatology Research and Practice, 2010 The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium‐independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, calcium‐dependent desmosomes, although hyperadhesion can ...
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Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.
PLoS Genetics, 2010 Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis.
Veronica G Beaudry +8 more
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Perp and Pemphigus: A Disease of Desmosome Destabilization [PDF]
, 2009 In this issue, Nguyen et al. demonstrate a role for Perp in desmosome assembly and trafficking and pemphigus IgG–mediated acantholysis, providing further insights into the complexity of desmosome structure and ...
Rubenstein, David S., Bektas, Meryem
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