Results 21 to 30 of about 11,604 (181)
Frontiers in Immunology, 2022 Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt +7 more
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Dermatology Research and Practice, 2010 The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium‐independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, calcium‐dependent desmosomes, although hyperadhesion can ...
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Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.
PLoS Genetics, 2010 Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis.
Veronica G Beaudry +8 more
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Frontiers in Cell and Developmental Biology, 2020 BackgroundRecent studies demonstrated that Aquamin®, a calcium-, magnesium-rich, multi-mineral natural product, improves barrier structure and function in colonoids obtained from the tissue of healthy subjects.
Muhammad N. Aslam +11 more
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Journal of the Formosan Medical Association, 2008 Background/Purpose: Desmosome gene mutations have been reported in patients with arrhythmogenic right ventricular dysplasia (ARVD). However, there are hardly any genetic studies in Asians.
Chih-Chieh Yu +7 more
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Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model
Frontiers in Medicine, 2022 Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine +14 more
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The Journal of Cell Biology, 1970 During the pupal stage of moths, a mass of connective tissue develops on the dorsal side of the abdominal nerve cord . The cells, which secrete the fibrous matrix, are originally close together, but as they secrete the matrix, they are pushed apart, with a corresponding decrease in their size .
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Diagnostic Techniques in Autoimmune Blistering Diseases
British Journal of Biomedical Science, 2023 Autoimmune blistering diseases (AIBD) comprise a heterogeneous group of uncommon disorders of the skin and mucous membranes, characterised by antibodies targeting structural proteins within epithelial tissue and the underlying basement membrane.
John B. Mee
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The genetic background of arrhythmogenic right ventricular cardiomyopathy
Journal of Arrhythmia, 2016 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by degeneration of the right ventricle and ventricular tachycardia originating from the right ventricle.
Seiko Ohno, MD, PhD
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Dsg2 Upregulation as a Rescue Mechanism in Pemphigus
Frontiers in Immunology, 2020 In pemphigus vulgaris (PV), autoantibodies directed against the desmosomal cadherin desmoglein (Dsg) 3 cause loss of intercellular adhesion. It is known that Dsg3 interactions are directly inhibited by autoantibody binding and that Dsg2 is upregulated in
Anna M. Sigmund +5 more
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