Results 161 to 170 of about 8,293 (200)

Changes in desmoglein 1 expression and subcellular localization in cultured keratinocytes subjected to anti‐desmoglein 1 pemphigus autoimmunity

Journal of Cellular Physiology, 2006
AbstractThe complexity of pemphigus acantholysis together with the weak expression of desmoglein 1 (Dsg1) in cultured keratinocytes have made the study on the pathogenic action of anti‐Dsg1 antibodies quite difficult. The pathophysiology of the acantholytic phenomenon could depend on the reduction of Dsg1 adhesion function occurring after its massive ...
CIRILLO N, GOMBOS F, LANZA, Alessandro
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Cutaneous pemphigus vulgaris with absence of desmoglein 1 autoantibodies. An example of the extended desmoglein compensation theory.

The Australasian journal of dermatology, 2014
A 79 year-old male patient presented clinically as a typical case of pemphigus foliaceus. He displayed a seborrhoeic pattern of crusting and erosions with an absence of oral involvement. Surprisingly, a biopsy showed suprabasilar acantholysis and direct immunofluorescence consistent with pemphigus vulgaris.
Carew, Benjamin, Wagner, Godfrey
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Oral lichen planus with antibodies to desmogleins 1 and 3

The Journal of Dermatology, 2014
AbstractLichen planus (LP) is a chronic inflammatory disorder involving the skin or mucous membranes. Previous studies have demonstrated that some LP patients showed positive enzyme‐linked immunosorbent assay (ELISA) for desmoglein (DSG) antibodies. We report a case with intractable painful oral lesions.
Chihiro, Kinjyo, Takahide, Kaneko, Ayumi, Korekawa, Akiko, Rokunohe, Takayuki, Aizu, Yasushi, Matsuzaki, Hajime, Nakano, Daisuke, Sawamura   +7 more
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Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering

Cellular and Molecular Life Sciences, 2019
Plakophilins (Pkp) are desmosomal plaque proteins crucial for desmosomal adhesion and participate in the regulation of desmosomal turnover and signaling. However, direct evidence that Pkps regulate clustering and molecular binding properties of desmosomal cadherins is missing. Here, keratinocytes lacking either Pkp1 or 3 in comparison to wild type (wt)
Fuchs M, Foresti M, Radeva MY, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J, Vielmuth F   +8 more
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Expression of pemphigus‐autoantigen desmoglein 1 in human thymus

Tissue Antigens, 2008
AbstractDesmoglein (Dsg) 1 is a transmembrane glycoprotein of the desmosome allowing cell–cell adhesion between keratinocytes, whose expression is restricted to stratified squamous epithelia‐like epidermis. Dsg1 is the target autoantigen of pathogenic autoantibodies produced by pemphigus foliaceus and 50% of pemphigus vulgaris patients in a Dsg1 ...
H, Mouquet, S, Berrih-Aknin, J, Bismuth, P, Joly, D, Gilbert, F, Tron   +5 more
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Autoantibodies to desmogleins 1 and 3 in patients with lichen planus

Archives of Dermatological Research, 2017
There is controversy about the role of autoantibodies against desmoglein 1 and 3 (Dsg1 and 3) in the pathogenesis of lichen planus (LP); the authors planned this study to determine the presence of circulating levels of these antibodies in patients with different types of oral LP and to compare that with cutaneous LP and healthy controls.
Lajevardi, Vahide, Halaji, Zahra, Ghaedi, Forugh, Saljoughi, Nazi   +3 more
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Split stories converge at desmoglein 1.

Nature Medicine, 2000
The exact mechanism by which exfoliative toxin A (ETA), producedby Staphylococcal aureus, causes epidermal blistering has been elusive.A combined knowledge of the pathogenesis of pemphigus, cell adhesion mechanisms,and the amino acid sequence of ETA led to a simple answer (pages 1275–1277 ).
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Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion

Differentiation, 2004
Desmoglein 1 (Dsg1) is a component of desmosomes present in the upper epidermis and can be targeted by autoimmune antibodies or bacterial toxins, resulting in skin blistering diseases. These defects in tissue integrity are believed to result from compromised desmosomal adhesion; yet, previous attempts to directly test the adhesive roles of desmosomal ...
Spiro, Getsios, Evangeline V, Amargo, Rachel L, Dusek, Ken, Ishii, Linda, Sheu, Lisa M, Godsel, Kathleen J, Green   +6 more
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Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris

Journal of Dermatological Science, 2011
An active disease mouse model of pemphigus vulgaris (PV) was developed using the adoptive transfer of splenocytes from Dsg3(-/-) mice with a mixed C57BL/6J (B6) and 129/Sv genetic background into B6-Rag2(-/-) mice. Further immunological investigation is needed to resolve the genetic mismatch between host and recipient mice.
Tsuyoshi, Hata, Koji, Nishifuji, Kouji, Shimoda, Takashi, Sasaki, Taketo, Yamada, Takeji, Nishikawa, Shigeo, Koyasu, Masayuki, Amagai   +7 more
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Desmoglein 3 and 1 in desquamative gingivitis

2003
Evaluation of dsg 3 and 1 autoantibodies may play an important role in the desquamative gingivitis.
Brozović-Sistig, Suzana, Cekić-Arambašin, Ana, Lukač, Josip, Vučićević Boras, Vanja   +3 more
openaire   +1 more source