Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
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A case series of desmoplakin cardiomyopathy: a mimic of viral myocarditis
European Heart Journal: Case Reports, 2022 Background Clinical features and imaging presentation of myocarditis can overlap with other inflammatory or arrhythmogenic cardiomyopathies. Desmoplakin (DSP) is an important structural cardiac protein.
K. Rezaei Bookani +6 more
semanticscholar +1 more source
Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. [PDF]
PLoS ONE, 2014 Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation
Kaelyn Sumigray +2 more
doaj +1 more source
The molecular genetic analysis of the expanding pachyonychia congenita case collection [PDF]
, 2014 BACKGROUND: Pachyonychia congenita (PC) is a rare autosomal dominant keratinizing disorder characterized by severe, painful, palmoplantar keratoderma and nail dystrophy, often accompanied by oral leucokeratosis, cysts and follicular keratosis.
Al-Asadi, E. +9 more
core +2 more sources
Science Advances, 2022 Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In terms of dedifferentiation, in vitro cellular reprogramming has been proposed to share common processes with in vivo tissue ...
Jeongmin Ha +22 more
semanticscholar +1 more source
Desmoplakin’s tail gets the message [PDF]
Journal of Cell Biology, 2015 ![Figure][1] Desmoplakin (green) normally resides at cell–cell junctions (top), but in cells that can’t methylate its tail (bottom), it gathers along intermediate filaments (red). Cells control the junction protein desmoplakin by methylating and phosphorylating its tail, [Albrecht ...
openaire +2 more sources
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]
, 2006 PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E. +4 more
core +2 more sources
Netherlands Heart Journal, 2022 We present two female patients with recurrent episodes of myocardial injury, consisting of acute chest pain and elevated cardiac markers without coronary artery disease.
S. Schoonvelde +7 more
semanticscholar +1 more source
Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy [PDF]
, 2019 BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and an increased risk of sudden cardiac death (SCD).
Asimaki, A +20 more
core +1 more source
The EPItome of Ablation in Desmoplakin Cardiomyopathy
JACC: Clinical ElectrophysiologyChristopher C. Cheung, Yuval Shafir
openalex +3 more sources