Results 51 to 60 of about 30,950 (250)

Desmoplastic nevus: clinicopathologic keynotes

, 2009
We describe 3 cases of desmoplastic nevus with special emphasis on some repetitive dermoscopic and histopathologic features, which-if confirmed on larger series-could allow to identify desmoplastic nevus as a specific clinicopathologic entity within the ...
Annese Pietro, Brasiello Marcella, Francione Sabrina, Moscarella E, ARGENZIANO, Giuseppe, Zalaudek I, Francione S, Moscarella Elvira, Ferrara Gerardo, Ferrara G, Argenziano Giuseppe, Brasiello M, Giorgio CM, Annese P, Giorgio Caterina M., Marcella Brasiello, Gerardo Ferrara, Elvira Moscarella, Iris Zalaudek, Sabrina Francione, Pietro Annese, Giuseppe Argenziano, Caterina M Giorgio   +22 more
core   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Rare Desmoplastic Fibroma in Ramus and Mandibular Angle: Presentation of a Case Report With Review of Literature

Acta Medica Iranica, 2020
Desmoplastic fibroma is a rare, benign fibrous tumor of bone which is locally aggressive. The mandible is the most prevalent affected of the facial bones.
Azadehzeinab Titidej, Maryam Jolehar
doaj   +1 more source

Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases

The Journal of Pathology: Clinical Research, 2022
Histopathological growth patterns (HGPs) are a reliable, reproducible, and strong prognostic biomarker that can be assessed on haematoxylin and eosin‐stained sections of resected colorectal liver metastases (CRLM).
Pieter MH Nierop, Diederik J Höppener, Florian E Buisman, Eric P van derStok, Boris Galjart, Vinod P Balachandran, William R Jarnagin, T Peter Kingham, Jinru Shia, Murielle Mauer, Bernard Nordlinger, Catherine Julié, Bas Groot Koerkamp, Michail Doukas, Peter B Vermeulen, Dirk J Grünhagen, Michael I D'Angelica, Cornelis Verhoef   +17 more
doaj   +1 more source

Desmoplastic ameloblastoma of mandible [PDF]

BMJ Case Reports, 2013
Desmoplastic ameloblastoma is one of the six histopathological subtypes of ameloblastoma. The age and gender groups affected by desmoplastic are similar to those affected by the conventional ameloblastoma. It usually presents as a painless enlargement of the jaw.
Preeti P, Nair, Guruprasad R, Bhat, Shiba, Neelakantan, Rhiti, Chatterjee   +3 more
openaire   +2 more sources

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

DESMOPLASTIC FIBROMA WITH PERIOSTEAL REACTION [PDF]

, 2007
Desmoplastic fibroma is a rare, locally aggressive, benign lesion. A case of desmoplastic fibroma of left side of mandible is reported. The lesion presented as painless mass in left posterior portion of mandible of a 7-year-old girl.
G. Adham-Fumani H Dalili-Kajan, Z. Dalili-Kajan   +1 more
core  

Clinicopathologic predictors of survival in patients with desmoplastic melanoma. [PDF]

PLoS ONE, 2015
Desmoplastic melanoma is a unique subtype of melanoma which typically affects older patients who often have comorbidities that can adversely affect survival.
Dale Han, Gang Han, Xiuhua Zhao, Nikhil G Rao, Jane L Messina, Suroosh S Marzban, Amod A Sarnaik, C Wayne Cruse, Vernon K Sondak, Jonathan S Zager   +9 more
doaj   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source