Results 91 to 100 of about 4,329 (200)
British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens +15 more
wiley +1 more source
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]
Journal of Lipid Research, 2014 The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis, 3β ...
Winnie Luu +5 more
doaj +1 more source
Cholesterol Within Phosphatidylcholine Liposomes Attenuates the Expression of Cytokines
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.We previously showed that liposomes made of phosphatidylcholine, a natural phospholipid found in plasma membranes, exosomes, and lipid nanoparticles, strongly induce TNF‐α expression in macrophages. Here, we found that adding free cholesterol to these liposomes significantly reduces this response by inhibiting NF‐κB activation.
David M. Cauvi +4 more
wiley +1 more source
Journal of Lipid Research, 2009 Data is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors.
Nirupa R. Matthan +6 more
doaj +1 more source
Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet [PDF]
, 2014 Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that ...
Dionne, MS +5 more
core +1 more source
Host Organelle Interactions Facilitate Cholesterol Acquisition by Trypanosoma cruzi Amastigotes
Journal of Eukaryotic Microbiology, Volume 72, Issue 4, July/August 2025.ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease in Latin America. The amastigote, the replicative intracellular form, is essential for infection persistence in vertebrate hosts. These forms exhibit remarkable adaptability, modulating metabolism and growth according to host cell resource availability ...
Carolina de Lima Alcantara +3 more
wiley +1 more source
Physiological Reports, Volume 13, Issue 12, June 2025.Abstract Compared with 2D monolayers, 3D models more closely mimic native muscle tissue and allow functional measurements. A more complete understanding of how culture conditions and duration affect myotube maturity/function is crucial for validating the transition to 3D systems.
Benjamin R. Tollitt +5 more
wiley +1 more source
The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
Journal of Lipid Research, 2006 Mice with a targeted mutation of 3β-hydroxysterol Δ7-reductase (Dhcr7) that cannot convert 7-dehydrocholesterol to cholesterol were used to identify the origin of fetal sterols.
G.S. Tint +4 more
doaj +1 more source
A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat
Epilepsia, Volume 66, Issue 5, Page 1394-1405, May 2025.Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo +6 more
wiley +1 more source
Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy. [PDF]
, 2018 BackgroundEquine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet.
Bordbari, Matthew H +9 more
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