Results 131 to 140 of about 2,350 (174)

Alzheimer's Disease: Brain Desmosterol Levels [PDF]

Journal of Alzheimer's Disease, 2013
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of the gene coding for the enzyme DHCR24, which metabolizes desmosterol to ...
Thomas, Wisniewski, Kia, Newman, Norman B, Javitt   +2 more
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DEPOSITION OF DESMOSTEROL IN THE LESIONS OF EXPERIMENTAL ATHEROSCLEROSIS

Lancet, The, 1962
J Avigan, Joel Avigan
exaly   +3 more sources

Desmosterol in human milk

Lipids, 1983
AbstractMilk samples were collected from mothers at 2,6, 12 and 16 weeks postpartum. Desmosterol was found to be present in all the milk samples. Identification of desmosterol was based on retention times with two gas liquid chromatography (GLC) columns and verified by GC‐m ass spectrometry.
R M, Clark, M B, Fey, R G, Jensen, D W, Hill   +3 more
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Desmosterol in developing rat brain

Journal of the American Oil Chemists' Society, 1965
AbstractThe brain of the young rat contains appreciable amounts of desmosterol (24‐dehydrocholesterol). The peak desmosterol concentration is seen during the first week of life and only traces of this sterol are found at 21 days. The spinal cord also contains some desmosterol.
D, Kritchevsky, S A, Tepper, N W, DiTullio, W L, Holmes   +3 more
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The influence of cholesterol precursor – desmosterol – on artificial lipid membranes

Biochimica Et Biophysica Acta - Biomembranes, 2015
The disorders in cholesterol biosynthesis pathway and various diseases manifest in the accumulation of cholesterol precursors in the human tissues and cellular membranes. In this paper the effect of desmosterol--one of cholesterol precursors--on model lipid membranes was studied.
Michal Flasinski, Paweł Wydro, Katarzyna Hac-Wydro   +2 more
exaly   +4 more sources

Desmosteryl sulfate and desmosterol in hamster epididymal spermatozoa

Steroids, 1974
Abstract Desmosteryl sulfate composes 95% of the sterol sulfate fraction of hamster epididymal spermatozoa at a level of 10 mg/g dry weight. Desmosterol represents as much as 40% of the free sterol fraction of these cells. Only cholesterol was detected in the free sterol fraction from plasma and liver of the same animals.
G, Bleau, W J, VandenHeuvel
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Solubility of Desmosterol in Five Organic Solvents

Journal of Chemical & Engineering Data, 2008
The solubilities of desmosterol in methanol, ethanol, acetone, ethyl acetate, and acetonitrile were measured. The solubilities of desmosterol in these solvents increased with temperature and varied greatly with the solvent from a minimum of 0.1151 mol·L−1 in acetonitrile at 300.8 K to a maximum of 1.102 mol·L−1 in ethyl acetate at 332.8 K.
Wei Chen, Baogen Su, Huabin Xing, Yiwen Yang, Qilong Ren   +4 more
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Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid

Steroids, 1977
A new synthesis of desmosterol was described using hyodeoxycholic acid (3alpha,6alpha-dihydroxy-5beta-cholanic acid) as a starting material. Epidesmosterol (3alpha-hydroxycholesta-5,24-diene) was also synthesized for the first time from the same starting material.
K, Ochi, I, Matsunaga, M, Shindo, C, Kaneko   +3 more
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Desmosterol levels in human foetal brain—a reassessment

Journal of Neurochemistry, 1973
Cholesterol, an essential component of the central myelin sheath, is synthesized in large quantities during myelination in the central nervous system. However, in rat brain prior to and during the early stages of myelination desmosterol accumulates in significant amounts (Fumagalli and Paoletti, 1963; Kritchevsky and Holmes, 1962)
R G, Dennick, P D, Dean, D A, Abramovich
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HPLC analysis of desmosterol, 7‐dehydrocholesterol, and cholesterol

Lipids, 1989
AbstractA simple and sensitive method to analyzed mixtures of desmosterol, 7‐dehydrocholesterol and cholesterol is described. The method involves the oxidative conversion of the sterols with cholesterol oxidase, followed by high performance liquid chromatographic (HPLC) analysis.
E H, Goh, S M, Colles, K D, Otte
openaire   +2 more sources