Results 221 to 230 of about 50,053 (275)

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Synergistic halide and phosphate ester electrolytes for overcoming corrosion and interfacial challenges in magnesium batteries. [PDF]

Chem Sci
Yang X, Zhou Y, Zhou J, Huang X, Ao X, Ding G, Huang X, Zhou N, Cui G, Yang Y.   +9 more
europepmc   +1 more source

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Direct Molecular Evidence for Desolvation-Controlled Lithium-Ion Insertion at Graphite Electrodes in Highly Concentrated Electrolytes. [PDF]

J Phys Chem Lett
Sawayama S, Matsugami M, Fujii K.
europepmc   +1 more source

A Common Reference Material for Mass‐Dependent Sn Isotope Compositions: An Inter‐Laboratory Calibration Approach

Geostandards and Geoanalytical Research, EarlyView.
Key Points We recommend using the notation δ122/118SnNIST SRM 3161a for mass‐dependent Sn isotope data. We derived conversion factors relative to NIST SRM 3161a for Puri Sn CEZA (0.132 ± 0.011‰), Sn Lyon (0.229 ± 0.016‰), Sn IPGP (0.162 ± 0.018‰). Tin isotope compositions are presented for SPEX CertiPrep Sn and nine USGS reference materials.
Aurélia C.E. Meister, Manuela A. Fehr, Quentin Amet, Gerhard Brügmann, Caroline Fitoussi, Matthias Friebel, Weiqiang Li, Frederic Moynier, Jia‐Xin She, Xueying Wang, Maria Schönbächler   +10 more
wiley   +1 more source

Electrolyte design for aqueous batteries. [PDF]

Sci Adv
Hong H, Nian Q, Guo X, Li Q, Zhi C.
europepmc   +1 more source

A Comparative Analysis of Maillard‐Derived α‐Dicarbonyl Compounds and Advanced Glycation End Products in Fresh, Wet, Kibble, and Freeze‐Dried Dog Foods

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Thermal processing of pet foods can lead to the formation of harmful Maillard reaction products (MRPs), which may compromise nutritional quality and pose health risks to companion animals. This study compared the levels of MRPs in 41 commercial dog foods, including fresh (n = 15), kibble (n = 13), wet (n = 10), freeze‐dried (n = 2), and cold ...
Tolgahan Kocadağlı, Ciara Clarke, Vural Gökmen   +2 more
wiley   +1 more source

Thermodynamic Data Remain a Hot Tip for Decoding Binding Affinity and Water Impact on Protein-Ligand Complex Formation to Assist Lead Optimization. [PDF]

J Med Chem
Klebe G.
europepmc   +1 more source

Dehydration‐driven organization of metabolites into NaDES‐like assemblies in orthodox seeds

New Phytologist, EarlyView.
Summary Desiccation tolerance in plants, especially during orthodox seed dehydration, relies on compatible solute accumulation, complex molecular mechanisms, and intermolecular organizations that remain poorly understood. We combined metabolite profiling, mass spectrometry imaging, and electrospray and cold‐spray ionization mass spectrometry to ...
Youcef Haddad, Thomas Delhaye, Emmanuelle Limanton, Denis Morineau, Maëna Le Corvec, Christine Deponge, Anne Levrel, Alain Moréac, Virginie Nazabal, David Rondeau, Ludovic Paquin, Alain Bouchereau   +11 more
wiley   +1 more source

Multifunctional pectin derivatives as anticancer agents in colorectal cancer via synthesis, computational insights, and modulation of NRF2/HO-1, HIF-1α, and VEGF/PDGF-D signaling pathways. [PDF]

Sci Rep
Elsayed GH, Fahim AM.
europepmc   +1 more source