Results 31 to 40 of about 31,617 (291)
Pharmaceutics, 2023 Carvedilol, an anti-hypertensive medication commonly prescribed by healthcare providers, falls under the BCS class II category due to its low-solubility and high-permeability characteristics, resulting in limited dissolution and low absorption when taken
Mohamed S. Attia +3 more
doaj +1 more source
Pharmaceutics, 2020 The aim of this study is to prepare and characterize an amino-dextran nanoparticle (aDNP) platform and investigate two loading strategies for unmethylated cytosine-phosphate-guanine (CpG) oligonucleotide. aDNP was prepared by desolvation of amino-dextran
Hien V. Nguyen +4 more
doaj +1 more source
Crystal Structure, Stability and Desolvation of the Solvates of Sorafenib Tosylate
Crystals, 2019 In this study, three solvates of sorafenib tosylate were obtained from methanol, ethanol and n-methyl-2-pyrrolidone (NMP) after solvate screening and the effect of solvent on the formation of solvate was analyzed. The solvents with high value of polarity/
Peng Yang +6 more
doaj +1 more source
Synthesis and Application of Albumin Nanoparticles Loaded with Prussian Blue Nanozymes
Colloids and Interfaces, 2022 Prussian blue nanozymes exhibit peroxidase-like catalytic activity and are therefore considered a stable and inexpensive alternative to natural peroxidases in the enzyme-linked immunosorbent assay (ELISA).
Pavel Khramtsov +6 more
doaj +1 more source
Rapid Context-Dependent Ligand Desolvation in Molecular Docking [PDF]
, 2016 In structure-based screens for new ligands, a molecular docking algorithm must rapidly score many molecules in multiple configurations, accounting for both the ligand’s interactions with receptor and its competing interactions with solvent.
Brian K. Shoichet (434829) +1 more
core +1 more source
Investigation of mechanical properties of C70 nanowhiskers through bending and nanoindentation
Carbon Trends, 2023 The mechanical properties of C70 nanowhiskers (NWs) grown using the liquid–liquid interfacial precipitation method were investigated through bending and nanoindentation experiments.
Miyabi Watanabe +3 more
doaj +1 more source
Prediction of Protein-Protein Interaction Sites Using Electrostatic Desolvation Profiles [PDF]
, 2010 Protein-protein complex formation involves removal of water from the interface region. Surface regions with a small free energy penalty for water removal or desolvation may correspond to preferred interaction sites.
Fiorucci, Sébastien, Zacharias, Martin
core +1 more source
Molecular conformational evolution mechanism during nucleation of crystals in solution
IUCrJ, 2020 Nucleation of crystals from solution is fundamental to many natural and industrial processes. In this work, the molecular mechanism of conformational polymorphism nucleation and the links between the molecular conformation in solutions and in crystals ...
Xin Li +8 more
doaj +1 more source
Solvent Effects on Kinetics and Electrochemical Performances of Rechargeable Aluminum Batteries
Energy Material Advances, 2022 The rechargeable aluminum batteries (RAB) have shown great potential for energy storage applications due to their low-cost and superior volumetric capacity.
Sichen Gu +7 more
doaj +1 more source
Improving the desolvation penalty in empirical protein pKa modeling [PDF]
, 2011 Unlike atomistic and continuum models, empirical pk(a) predicting methods need to include desolvation contributions explicitly. This study describes a new empirical desolvation method based on the Born solvation model.
Olsson, Mats Henrik Mikael +1 more
core +1 more source